Search Results - "Kiara, Steven M."

In Vitro Activities of Piperaquine, Lumefantrine, and Dihydroartemisinin in Kenyan Plasmodium falciparum Isolates and Polymorphisms in pfcrt and pfmdr1 by MWAI, Leah, KIARA, Steven M, ABDIRAHMAN, Abdi, POLE, Lewa, RIPPERT, Anja, DIRIYE, Abdi, BULL, Pete, MARSH, Kevin, BORRMANN, Steffen, NZILA, Alexis

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Chloroquine resistance before and after its withdrawal in Kenya by Mwai, Leah, Ochong, Edwin, Abdirahman, Abdi, Kiara, Steven M, Ward, Steve, Kokwaro, Gilbert, Sasi, Philip, Marsh, Kevin, Borrmann, Steffen, Mackinnon, Margaret, Nzila, Alexis

“…The spread of resistance to chloroquine (CQ) led to its withdrawal from use in most countries in sub-Saharan Africa in the 1990s. In Malawi, this withdrawal…”
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Repeat Polymorphisms in the Low-Complexity Regions of Plasmodium falciparum ABC Transporters and Associations with In Vitro Antimalarial Responses by OKOMBO, John, ABDI, Abdirahman I, KIARA, Steven M, MWAI, Leah, POLE, Lewa, SUTHERLAND, Colin J, NZILA, Alexis, OCHOLA-OYIER, Lynette Isabella

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In Vitro Activity of Antifolate and Polymorphism in Dihydrofolate Reductase of Plasmodium falciparum Isolates from the Kenyan Coast: Emergence of Parasites with Ile-164-Leu Mutation by KIARA, Steven M, OKOMBO, John, MASSENO, Victor, MWAI, Leah, OCHOLA, Isabella, BORRMANN, Steffen, NZILA, Alexis

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Baseline In Vitro Activities of the Antimalarials Pyronaridine and Methylene Blue against Plasmodium falciparum Isolates from Kenya by Okombo, John, Kiara, Steven M, Mwai, Leah, Pole, Lewa, Ohuma, Eric, Ochola, Lynette Isabella, Nzila, Alexis

“…We have analyzed the in vitro activities of pyronaridine and methylene blue against 59 Plasmodium falciparum isolates from Kenya in association with…”
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A genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in Kenya by Wendler, Jason P, Okombo, John, Amato, Roberto, Miotto, Olivo, Kiara, Steven M, Mwai, Leah, Pole, Lewa, O'Brien, John, Manske, Magnus, Alcock, Dan, Drury, Eleanor, Sanders, Mandy, Oyola, Samuel O, Malangone, Cinzia, Jyothi, Dushyanth, Miles, Alistair, Rockett, Kirk A, MacInnis, Bronwyn L, Marsh, Kevin, Bejon, Philip, Nzila, Alexis, Kwiatkowski, Dominic P

“…Drug resistance remains a chief concern for malaria control. In order to determine the genetic markers of drug resistant parasites, we tested the genome-wide…”
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In Vitro Activities of Quinine and Other Antimalarials and pfnhe Polymorphisms in Plasmodium Isolates from Kenya by OKOMBO, John, KIARA, Steven M, RONO, Josea, MWAI, Leah, POLE, Lewa, OHUMA, Eric, BORRMANN, Steffen, OCHOLA, Lynette Isabella, NZILA, Alexis

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Characteristics of Plasmodium falciparum dhfr Haplotypes That Confer Pyrimethamine Resistance, Kilifi, Kenya, 1987–2006 by Certain, Laura K., Briceño, Marnie, Kiara, Steven M., Nzila, Alexis M., Watkins, William M., Sibley, Carol Hopkins

“…Resistance to the antimalarial drug sulfadoxine-pyrimethamine (SP) emerged in Plasmodium falciparum from Asia in the 1960s and subsequently spread to Africa…”
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The MSPDBL2 codon 591 polymorphism is associated with lumefantrine in vitro drug responses in Plasmodium falciparum isolates from Kilifi, Kenya by Ochola-Oyier, Lynette Isabella, Okombo, John, Mwai, Leah, Kiara, Steven M, Pole, Lewa, Tetteh, Kevin K A, Nzila, Alexis, Marsh, Kevin

“…The mechanisms of drug resistance development in the Plasmodium falciparum parasite to lumefantrine (LUM), commonly used in combination with artemisinin, are…”
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Population genetic analysis of Plasmodium falciparum parasites using a customized Illumina GoldenGate genotyping assay by Campino, Susana, Auburn, Sarah, Kivinen, Katja, Zongo, Issaka, Ouedraogo, Jean-Bosco, Mangano, Valentina, Djimde, Abdoulaye, Doumbo, Ogobara K, Kiara, Steven M, Nzila, Alexis, Borrmann, Steffen, Marsh, Kevin, Michon, Pascal, Mueller, Ivo, Siba, Peter, Jiang, Hongying, Su, Xin-Zhuan, Amaratunga, Chanaki, Socheat, Duong, Fairhurst, Rick M, Imwong, Mallika, Anderson, Timothy, Nosten, François, White, Nicholas J, Gwilliam, Rhian, Deloukas, Panos, MacInnis, Bronwyn, Newbold, Christopher I, Rockett, Kirk, Clark, Taane G, Kwiatkowski, Dominic P

“…The diversity in the Plasmodium falciparum genome can be used to explore parasite population dynamics, with practical applications to malaria control. The…”
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Antimalarial activity of isoquine against Kenyan Plasmodium falciparum clinical isolates and association with polymorphisms in pfcrt and pfmdr1 genes by Okombo, John, Kiara, Steven M, Abdirahman, Abdi, Mwai, Leah, Ohuma, Eric, Borrmann, Steffen, Nzila, Alexis, Ward, Steve

“…The use of amodiaquine in prophylaxis is associated with serious toxicity, resulting from its metabolic conversion into a reactive quinone-imine metabolite by…”
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Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing by Manske, Magnus, Miotto, Olivo, Campino, Susana, Auburn, Sarah, Almagro-Garcia, Jacob, Maslen, Gareth, O’Brien, Jack, Djimde, Abdoulaye, Doumbo, Ogobara, Zongo, Issaka, Ouedraogo, Jean-Bosco, Michon, Pascal, Mueller, Ivo, Siba, Peter, Nzila, Alexis, Borrmann, Steffen, Kiara, Steven M., Marsh, Kevin, Jiang, Hongying, Su, Xin-Zhuan, Amaratunga, Chanaki, Fairhurst, Rick, Socheat, Duong, Nosten, Francois, Imwong, Mallika, White, Nicholas J., Sanders, Mandy, Anastasi, Elisa, Alcock, Dan, Drury, Eleanor, Oyola, Samuel, Quail, Michael A., Turner, Daniel J., Ruano-Rubio, Valentin, Jyothi, Dushyanth, Amenga-Etego, Lucas, Hubbart, Christina, Jeffreys, Anna, Rowlands, Kate, Sutherland, Colin, Roper, Cally, Mangano, Valentina, Modiano, David, Tan, John C., Ferdig, Michael T., Amambua-Ngwa, Alfred, Conway, David J., Takala-Harrison, Shannon, Plowe, Christopher V., Rayner, Julian C., Rockett, Kirk A., Clark, Taane G., Newbold, Chris I., Berriman, Matthew, MacInnis, Bronwyn, Kwiatkowski, Dominic P.

“…Next-generation sequencing is used here to analyse Plasmodium falciparum genome variation directly from clinical blood samples, as well as cultured isolates,…”
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In Vitro Activities of Piperaquine, Lumefantrine, and Dihydroartemisinin in Kenyan Plasmodium falciparum Isolates and Polymorphisms in p fcrt and p fmdr1 by Mwai, Leah, Kiara, Steven M., Abdirahman, Abdi, Pole, Lewa, Rippert, Anja, Diriye, Abdi, Bull, Pete, Marsh, Kevin, Borrmann, Steffen, Nzila, Alexis

“…ABSTRACT We have analyzed the in vitro chemosensitivity profiles of 115 Kenyan isolates for chloroquine (CQ), piperaquine, lumefantrine (LM), and…”
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Characteristics of Plasmodium faldparum dhfr Haplotypes That Confer Pyrimethamine Resistance, Kilifi, Kenya, 1987-2006 by Certain, Laura K., Briceño, Marnie, Kiara, Steven M., Nzila, Alexis M., Watkins, William M., Sibley, Carol Hopkins

“…Resistance to the antimalarial drug sulfadoxine-pyrimethamine (SP) emerged in Plasmodium faldparum from Asia in the 1960s and subsequently spread to Africa. It…”
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Temporal patterns of pyrimethamine resistance haplotypes in Kilifi, Kenya by Certain, Laura K., Briceño, Marnie, Kiara, Steven M., Nzila, Alexis M., Watkins, William M., Sibley, Carol Hopkins

“…Resistance to the antimalarial drug sulfadoxine-pyrimethamine (SP, Fansidar) emerged in Plasmodium falciparum parasites Asia in the 1960s and spread…”
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A Genome Wide Association Study of Plasmodium falciparum Susceptibility to 22 Antimalarial Drugs in Kenya: e96486 by Wendler, Jason P, Okombo, John, Amato, Roberto, Miotto, Olivo, Kiara, Steven M, Mwai, Leah, Pole, Lewa, Manske, Magnus, Alcock, Dan, Drury, Eleanor

“…Background Drug resistance remains a chief concern for malaria control. In order to determine the genetic markers of drug resistant parasites, we tested the…”
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