Search Results - "Kiani, Samira"

Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes by Ferdosi, Shayesteh R., Ewaisha, Radwa, Moghadam, Farzaneh, Krishna, Sri, Park, Jin G., Ebrahimkhani, Mo R., Kiani, Samira, Anderson, Karen S.

“…The CRISPR-Cas9 system has raised hopes for developing personalized gene therapies for complex diseases. Its application for genetic and epigenetic therapies…”
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Highly efficient Cas9-mediated transcriptional programming by Chavez, Alejandro, Scheiman, Jonathan, Vora, Suhani, Pruitt, Benjamin W, Tuttle, Marcelle, P R Iyer, Eswar, Lin, Shuailiang, Kiani, Samira, Guzman, Christopher D, Wiegand, Daniel J, Ter-Ovanesyan, Dmitry, Braff, Jonathan L, Davidsohn, Noah, Housden, Benjamin E, Perrimon, Norbert, Weiss, Ron, Aach, John, Collins, James J, Church, George M

“…The fusion of three transcriptional activation domains to a nuclease-deficient Cas9 achieves robust induction of gene expression and can induce differentiation…”
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Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6 by Guye, Patrick, Ebrahimkhani, Mohammad R., Kipniss, Nathan, Velazquez, Jeremy J., Schoenfeld, Eldi, Kiani, Samira, Griffith, Linda G., Weiss, Ron

“…Human induced pluripotent stem cells (hiPSCs) have potential for personalized and regenerative medicine. While most of the methods using these cells have…”
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Synthetic immunomodulation with a CRISPR super-repressor in vivo by Moghadam, Farzaneh, LeGraw, Ryan, Velazquez, Jeremy J., Yeo, Nan Cher, Xu, Chenxi, Park, Jin, Chavez, Alejandro, Ebrahimkhani, Mo R., Kiani, Samira

“…Transient modulation of the genes involved in immunity, without exerting a permanent change in the DNA code, can be an effective strategy to modulate the…”
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Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids by Velazquez, Jeremy J, LeGraw, Ryan, Moghadam, Farzaneh, Tan, Yuqi, Kilbourne, Jacquelyn, Maggiore, Joseph C, Hislop, Joshua, Liu, Silvia, Cats, Davy, Chuva de Sousa Lopes, Susana M, Plaisier, Christopher, Cahan, Patrick, Kiani, Samira, Ebrahimkhani, Mo R

“…Pluripotent stem cell (PSC)-derived organoids have emerged as novel multicellular models of human tissue development but display immature phenotypes, aberrant…”
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Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells by Forster, Ryan, Chiba, Kunitoshi, Schaeffer, Lorian, Regalado, Samuel G., Lai, Christine S., Gao, Qing, Kiani, Samira, Farin, Henner F., Clevers, Hans, Cost, Gregory J., Chan, Andy, Rebar, Edward J., Urnov, Fyodor D., Gregory, Philip D., Pachter, Lior, Jaenisch, Rudolf, Hockemeyer, Dirk

“…Genetically engineered human pluripotent stem cells (hPSCs) have been proposed as a source for transplantation therapies and are rapidly becoming valuable…”
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Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells by Forster, Ryan, Chiba, Kunitoshi, Schaeffer, Lorian, Regalado, Samuel G., Lai, Christine S., Gao, Qing, Kiani, Samira, Farin, Henner F., Clevers, Hans, Cost, Gregory J., Chan, Andy, Rebar, Edward J., Urnov, Fyodor D., Gregory, Philip D., Pachter, Lior, Jaenisch, Rudolf, Hockemeyer, Dirk

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Nitric oxide: a new concept in chronic sinusitis pathogenesis by Naraghi, Mohsen, MD, Deroee, Armin Farajzadeh, MD, Ebrahimkhani, MohammadReza, MD, Kiani, Samira, MD, Dehpour, AhmadReza, PhD

“…Abstract Purpose Exhaled NO is produced mainly in paranasal sinuses and nasal mucosa. Nasal NO has been suggested to have a variety of effects in nasal cavity…”
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Safe CRISPR: Challenges and Possible Solutions by Pineda, Michael, Lear, Ashley, Collins, James P., Kiani, Samira

“…Applications of CRISPR in human health and in gene drives are at the forefront of biological research as tools. This technology will affect humankind and our…”
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CRISPR transcriptional repression devices and layered circuits in mammalian cells by Kiani, Samira, Beal, Jacob, Ebrahimkhani, Mohammad R, Huh, Jin, Hall, Richard N, Xie, Zhen, Li, Yinqing, Weiss, Ron

“…Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9–based transcriptional repressors can be easily engineered to give rise to a large…”
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A CRISPR Odyssey into Cancer Immunotherapy by Delgado, Elizabeth, Kiani, Samira

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Cas9 gRNA engineering for genome editing, activation and repression by Kiani, Samira, Chavez, Alejandro, Tuttle, Marcelle, Hall, Richard N, Chari, Raj, Ter-Ovanesyan, Dmitry, Qian, Jason, Pruitt, Benjamin W, Beal, Jacob, Vora, Suhani, Buchthal, Joanna, Kowal, Emma J K, Ebrahimkhani, Mohammad R, Collins, James J, Weiss, Ron, Church, George

“…The length of a single guide RNA (gRNA) determines the function of Cas9. In this study 20-nt gRNAs allowed nuclease activity and genome editing, whereas 14-nt…”
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Genetic engineering of human pluripotent cells using TALE nucleases by Jaenisch, Rudolf, Hockemeyer, Dirk, Wang, Haoyi, Kiani, Samira, Lai, Christine S, Gao, Qing, Cassady, John P, Cost, Gregory J, Zhang, Lei, Santiago, Yolanda, Miller, Jeffrey C, Zeitler, Bryan, Cherone, Jennifer M, Meng, Xiangdong, Hinkley, Sarah J, Rebar, Edward J, Gregory, Philip D, Urnov, Fyodor D

“…Transcription activator–like effector nucleases (TALENs) are a new technology for modifying the genome at specific loci of interest. Hockemeyer et al . now…”
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Simulation-Based Engineering of Time-Delayed Safety Switches for Safer Gene Therapies by Scott, Helen, Sun, Dashan, Beal, Jacob, Kiani, Samira

“…CRISPR-based gene editing is a powerful tool with great potential for applications in the treatment of many inherited and acquired diseases. The longer that…”
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The NIH Somatic Cell Genome Editing program by Saha, Krishanu, Sontheimer, Erik J., Brooks, P. J., Dwinell, Melinda R., Gersbach, Charles A., Liu, David R., Murray, Stephen A., Tsai, Shengdar Q., Wilson, Ross C., Anderson, Daniel G., Asokan, Aravind, Banfield, Jillian F., Bankiewicz, Krystof S., Bao, Gang, Bulte, Jeff W. M., Bursac, Nenad, Campbell, Jarryd M., Carlson, Daniel F., Chaikof, Elliot L., Chen, Zheng-Yi, Cheng, R. Holland, Clark, Karl J., Curiel, David T., Dahlman, James E., Deverman, Benjamin E., Dickinson, Mary E., Doudna, Jennifer A., Ekker, Stephen C., Emborg, Marina E., Feng, Guoping, Freedman, Benjamin S., Gamm, David M., Gao, Guangping, Ghiran, Ionita C., Glazer, Peter M., Gong, Shaoqin, Heaney, Jason D., Hennebold, Jon D., Hinson, John T., Khvorova, Anastasia, Kiani, Samira, Lagor, William R., Lam, Kit S., Leong, Kam W., Levine, Jon E., Lewis, Jennifer A., Lutz, Cathleen M., Ly, Danith H., Maragh, Samantha, McCray, Paul B., McDevitt, Todd C., Mirochnitchenko, Oleg, Morizane, Ryuji, Murthy, Niren, Prather, Randall S., Ronald, John A., Roy, Subhojit, Roy, Sushmita, Sabbisetti, Venkata, Saltzman, W. Mark, Santangelo, Philip J., Segal, David J., Shimoyama, Mary, Skala, Melissa C., Tarantal, Alice F., Tilton, John C., Truskey, George A., Vandsburger, Moriel, Watts, Jonathan K., Wells, Kevin D., Wolfe, Scot A., Xu, Qiaobing, Xue, Wen, Yi, Guohua, Zhou, Jiangbing

“…The move from reading to writing the human genome offers new opportunities to improve human health. The United States National Institutes of Health (NIH)…”
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Molecular and Biochemical Evaluation of Ethyl Methanesulfonate-Induced Mutant Lines in Camelina sativa L by Kiani, Samira, Kahrizi, Danial, Varmira, Kambiz, Kassaee, Seyed Mehrdad

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Modelling post-implantation human development to yolk sac blood emergence by Hislop, Joshua, Song, Qi, Keshavarz F., Kamyar, Alavi, Amir, Schoenberger, Rayna, LeGraw, Ryan, Velazquez, Jeremy J., Mokhtari, Tahere, Taheri, Mohammad Naser, Rytel, Matthew, Chuva de Sousa Lopes, Susana M., Watkins, Simon, Stolz, Donna, Kiani, Samira, Sozen, Berna, Bar-Joseph, Ziv, Ebrahimkhani, Mo R.

“…Implantation of the human embryo begins a critical developmental stage that comprises profound events including axis formation, gastrulation and the emergence…”
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Accurate Predictions of Genetic Circuit Behavior from Part Characterization and Modular Composition by Davidsohn, Noah, Beal, Jacob, Kiani, Samira, Adler, Aaron, Yaman, Fusun, Li, Yinqing, Xie, Zhen, Weiss, Ron

“…A long-standing goal of synthetic biology is to rapidly engineer new regulatory circuits from simpler devices. As circuit complexity grows, it becomes…”
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Engineered CRISPR Systems for Next Generation Gene Therapies by Pineda, Michael, Moghadam, Farzaneh, Ebrahimkhani, Mo R, Kiani, Samira

“…An ideal in vivo gene therapy platform provides safe, reprogrammable, and precise strategies which modulate cell and tissue gene regulatory networks with a…”
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An enhanced CRISPR repressor for targeted mammalian gene regulation by Yeo, Nan Cher, Chavez, Alejandro, Lance-Byrne, Alissa, Chan, Yingleong, Menn, David, Milanova, Denitsa, Kuo, Chih-Chung, Guo, Xiaoge, Sharma, Sumana, Tung, Angela, Cecchi, Ryan J., Tuttle, Marcelle, Pradhan, Swechchha, Lim, Elaine T., Davidsohn, Noah, Ebrahimkhani, Mo R., Collins, James J., Lewis, Nathan E., Kiani, Samira, Church, George M.

“…The RNA-guided endonuclease Cas9 can be converted into a programmable transcriptional repressor, but inefficiencies in target-gene silencing have limited its…”
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