Search Results - "Kiang, Tony K.L."

Revolutionizing Therapeutic Drug Monitoring with the Use of Interstitial Fluid and Microneedles Technology by Kiang, Tony K L, Ranamukhaarachchi, Sahan A, Ensom, Mary H H

“…While therapeutic drug monitoring (TDM) that uses blood as the biological matrix is the traditional gold standard, this practice may be impossible,…”
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Pharmacokinetics, safety, and patient acceptability of subcutaneous versus intramuscular testosterone injection for gender-affirming therapy: A pilot study by Wilson, David M, Kiang, Tony K. L, Ensom, Mary H. H

“…PURPOSE.Results of a study comparing testosterone exposure and tolerability with subcutaneous versus i.m. administration are presented. METHODS.In a…”
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Population pharmacokinetics of mycophenolic acid in paediatric patients by Rong, Yan, Jun, Heajin, Kiang, Tony K.L.

“…Mycophenolic acid (MPA) is widely used in paediatric kidney transplant patients and sometimes prescribed for additional indications. Population pharmacokinetic…”
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Characterization of human sulfotransferases catalyzing the formation of p-cresol sulfate and identification of mefenamic acid as a potent metabolism inhibitor and potential therapeutic agent for detoxification by Rong, Yan, Kiang, Tony K.L.

“…p-Cresol sulfate, the primary metabolite of p-cresol, is a uremic toxin that has been associated with toxicities and mortalities. The study objectives were to…”
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Characterizations of Human UDP-Glucuronosyltransferase Enzymes in the Conjugation of p-Cresol by Rong, Yan, Kiang, Tony K L

“…Abstract p-Cresol is a uremic toxin that is formed by intestinal microbiota and extensively conjugated by first-pass metabolism. p-Cresol glucuronide exerts…”
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Significant Effects of Renal Function on Mycophenolic Acid Total Clearance in Pediatric Kidney Transplant Recipients with Population Pharmacokinetic Modeling by Rong, Yan, Wichart, Jenny, Hamiwka, Lorraine, Kiang, Tony K. L.

“…Background and Objectives Mycophenolic acid (MPA) is an immunosuppressant commonly prescribed in pediatric kidney transplantation to prevent graft rejection…”
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Mechanisms of Metabolism Interaction Between p-Cresol and Mycophenolic Acid by Rong, Yan, Kiang, Tony K L

“…Abstract Mycophenolic acid (MPA) is commonly prescribed for preventing graft rejection after kidney transplantation. The primary metabolic pathways of MPA are…”
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Recent lessons learned from population pharmacokinetic studies of mycophenolic acid: physiological, genomic, and drug interactions leading to the prediction of drug effects by Rong, Yan, Patel, Vrunda, Kiang, Tony K L

“…Mycophenolic acid (MPA) is a widely used immunosuppressant in transplantation and autoimmune disease. Highly variable pharmacokinetics have been observed with…”
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Population Pharmacokinetics of Mycophenolic Acid: An Update by Kiang, Tony K. L., Ensom, Mary H. H.

“…The most recent comprehensive reviews on the population pharmacokinetics of mycophenolic acid (MPA) were published in 2014. Since then, several population…”
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Bioavailability and Metabolism of Bioactive Peptide IRW with Angiotensin-Converting Enzyme 2 (ACE2) Upregulatory Activity in Spontaneously Hypertensive Rats by Wang, Zihan, Wang, Chu-Fan, Fan, Hongbing, Bao, Xiaoyu, Ashkar, Fatemeh, Li, Liang, Kiang, Tony K. L., Wu, Jianping

“…Peptide IRW is the first food-derived angiotensin-converting enzyme 2 (ACE2) upregulator. This study aimed to investigate the pharmacokinetic characteristics…”
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Population Pharmacokinetics of Mycophenolic Acid Co-Administered with Tacrolimus in Corticosteroid-Free Adult Kidney Transplant Patients by Rong, Yan, Mayo, Patrick, Ensom, Mary H. H., Kiang, Tony K. L.

“…Background and Objective Mycophenolic acid is commonly prescribed to adult kidney transplant recipients. Mycophenolic acid is extensively metabolized to…”
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Exposure-Toxicity Relationships of Mycophenolic Acid in Adult Kidney Transplant Patients by Kiang, Tony K. L., Ensom, Mary H. H.

“…Mycophenolic acid is commonly prescribed in adult kidney transplant recipients for preventing graft rejection. A therapeutic target for total mycophenolic acid…”
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UDP-glucuronosyltransferases and clinical drug-drug interactions by Kiang, Tony K L, Ensom, Mary H H, Chang, Thomas K H

“…UDP-glucuronosyltransferase (UGT) enzymes catalyze the conjugation of various endogenous substances (e.g., bilirubin) and exogenous compounds (e.g., drugs)…”
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Significant Correlations between p-Cresol Sulfate and Mycophenolic Acid Plasma Concentrations in Adult Kidney Transplant Recipients by Rong, Yan, Colbourne, Penny, Gourishankar, Sita, Kiang, Tony K. L.

“…Background and Objectives Mycophenolic acid (MPA) is a commonly prescribed life-long immunosuppressant for kidney transplant recipients. The frequently…”
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Development and validation of a sensitive liquid‐chromatography tandem mass spectrometry assay for mycophenolic acid and metabolites in HepaRG cell culture: Characterization of metabolism interactions between p‐cresol and mycophenolic acid by Rong, Yan, Kiang, Tony K.L.

“…Mycophenolic acid (MPA), a frequently used immunosuppressant, exhibits large inter‐patient pharmacokinetic variability. This study (a) developed and validated…”
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A Critical Review on the Clinical Pharmacokinetics, Pharmacodynamics, and Clinical Trials of Ceftaroline by Kiang, Tony K. L., Wilby, Kyle J., Ensom, Mary H. H.

“…Only a parenteral formulation of ceftaroline is commercially available, and the prodrug, ceftaroline fosamil, is hydrolyzed quickly and completely upon…”
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Clinical Pharmacokinetics and Pharmacodynamics of Anti-Tubercular Drugs in Pregnancy by Shiu, Jennifer R., Min, Alan, Kiang, Tony K. L.

“…The objectives of this qualitative review were to critically evaluate and summarize the currently available data on the use of anti-tuberculosis (TB) drugs…”
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Effects of p-Cresol on Oxidative Stress, Glutathione Depletion, and Necrosis in HepaRG Cells: Comparisons to Other Uremic Toxins and the Role of p-Cresol Glucuronide Formation by Zhu, Sang, Rong, Yan, Kiang, Tony K. L.

“…The toxicological effects of p-cresol have primarily been attributed to its metabolism products; however, very little human data are available in the key organ…”
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Advanced In Vitro HepaRG Culture Systems for Xenobiotic Metabolism and Toxicity Characterization by Ashraf, Muhammad Nadeem, Asghar, Muhammad Waheed, Rong, Yan, Doschak, Michael R., Kiang, Tony K. L.

“…Several HepaRG three-dimensional (3D) in vitro model systems have been developed to improve the predictability of xenobiotic metabolism and toxicity. In this…”
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Fundamentals of Population Pharmacokinetic Modelling : Modelling and Software by Kiang, Tony K L, Sherwin, Catherine M T, Spigarelli, Michael G, Ensom, Mary H H

“…Population pharmacokinetic modelling is widely used within the field of clinical pharmacology as it helps to define the sources and correlates of…”
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