Embryonic Intermediate Filaments, Nestin and Vimentin,Expression in the Spinal Cords of Rats with Experimental Autoimmune Encephalomyelitis

Intermediate filaments, including nestin and vi-mentin, are found in specific cell types in centralnervous system (CNS) tissues, particularly immatureglial cells and multipotent progenitor cells. In thepresent study, the expression patterns of nestin andvimentin in the spinal cords of rats with expe...

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Bibliographic Details
Published in:	Journal of veterinary science (Suwŏn-si, Korea) pp. 9 - 13
Main Authors:	Tae-kyunShin, Yong-dukLee, Ki-bumSim
Format:	Journal Article
Language:	Korean
Published:	대한수의학회 01-04-2003
Subjects:	수의학
Online Access:	Get full text
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Summary:	Intermediate filaments, including nestin and vi-mentin, are found in specific cell types in centralnervous system (CNS) tissues, particularly immatureglial cells and multipotent progenitor cells. In thepresent study, the expression patterns of nestin andvimentin in the spinal cords of rats with experimentalautoimmune encephalomyelitis (EAE) and the responseof cells containing filaments against acute autoimmuneinjury were examined by immunohistochemistry.Nestin immunostaining was only weakly detectedin vascular endothelial cells but not in any cell typesin the spinal cord in normal and adjuvant-immunizedrats.At the peak stage of EAE,nestin-immunoreativitywas recognized in some astrocytes in the gray matterand white matter. Vimentin was immunopositive insome astrocytes and macrophages in EAE lesions,while vimentin was normally detected in ependymalcells of central canals in the rat spinal cords.We postulate that normal animals may containmultipotent progenitor cells in the spinal cord pa-renchyma as well as in the subpial lesion and epen-dyma. Multipotent progenitor cells may activate totransform into necessary cells, including neurons,astrocytes or oligodendrocytes, depending on CNSneeds. Appropriate control of progenitor cells in theinjured CNS is an alternative choice for CNSremodeling. KCI Citation Count: 2
Bibliography:	G704-001401.2003.4.1.015
ISSN:	1229-845X 1976-555X