Trends in the epidemiology of inflammatory bowel disease among Jewish Israeli adolescents: a population‐based study

Summary Background The incidence and prevalence trends of inflammatory bowel disease (IBD) vary between developed and developing countries. Aim To investigate the prevalence and associated sociodemographic factors of IBD in Israeli Jewish adolescents Methods The files of the army medical corps were...

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Published in:	Alimentary pharmacology & therapeutics Vol. 49; no. 5; pp. 556 - 563
Main Authors:	Ghersin, Itai, Khteeb, Neron, Katz, Lior H., Daher, Saleh, Shamir, Raanan, Assa, Amit
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01-03-2019
Subjects:	Adolescent Adolescents Age Age of Onset Birth Children Cohort Studies Colon Confidence intervals Crohn's disease Crohns disease Cross-Sectional Studies Developing countries Diagnosis Epidemiology Female Humans Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - diagnosis Inflammatory Bowel Diseases - epidemiology Intestine Israel - epidemiology Jews LDCs Male origin Population studies Population Surveillance - methods Population-based studies prevalence Retrospective Studies Socioeconomic factors Socioeconomics Teenagers Trends Ulcerative colitis Israel prevalence Crohn's disease ulcerative colitis children origin
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Summary:	Summary Background The incidence and prevalence trends of inflammatory bowel disease (IBD) vary between developed and developing countries. Aim To investigate the prevalence and associated sociodemographic factors of IBD in Israeli Jewish adolescents Methods The files of the army medical corps were reviewed for adolescents recruited in 2002‐2016 with confirmed IBD. Covariate data included birth date, patient and parental country of birth, number of children in the household, age at diagnosis, and socioeconomic status. Findings were compared with the remaining recruits without IBD. Results Of the 1,144,213 adolescents recruited, 2372 (0.2%) had IBD (Crohn's disease, 68%). Median age of the cohort was 17.1 years (interquartile range, 16.9‐17.3). Over the study period, the annual point prevalence per 100,000 examinees significantly increased: total IBD, 58 to 373; Crohn's disease, 42 to 425; ulcerative colitis, 16 to 128. Mean age at IBD diagnosis decreased from 15.0 ± 2.8 years in 2002‐2008 to 14.3 ± 3.1 years in 2009‐2016 (P < 0.0001). Significance was maintained on separate analyses of Crohn's disease and ulcerative colitis. Both diseases were significantly less prevalent in subjects from families with at least one parent born in a developing country and ≥3 children. There was a significant association of lower socioeconomic status with lower prevalence of Crohn's disease (odds ratio 0.41, 95% confidence interval, 0.31‐0.54) and ulcerative colitis (odds ratio 0.25, 95% confidence interval, 0.15‐0.42). Conclusions The point prevalence of Crohn's disease and ulcerative colitis in Israeli Jewish adolescents increased six‐fold and eight‐fold, respectively, over 15 years along with a decrease in age at diagnosis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0269-2813 1365-2036
DOI:	10.1111/apt.15160