Search Results - "Khromov, Alexander S"

Molecular Mechanism of Telokin-mediated Disinhibition of Myosin Light Chain Phosphatase and cAMP/cGMP-induced Relaxation of Gastrointestinal Smooth Muscle by Khromov, Alexander S., Momotani, Ko, Jin, Li, Artamonov, Mykhaylo V., Shannon, John, Eto, Masumi, Somlyo, Avril V.

“…Phospho-telokin is a target of elevated cyclic nucleotide concentrations that lead to relaxation of gastrointestinal and some vascular smooth muscles (SM)…”
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Cep57, a multidomain protein with unique microtubule and centrosomal localization domains by Momotani, Ko, Khromov, Alexander S, Miyake, Tsuyoshi, Stukenberg, P Todd, Somlyo, Avril V

“…The present study demonstrates different functional domains of a recently described centrosomal protein, Cep57 (centrosomal protein 57). Endogenous Cep57…”
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Smooth muscle myosin: regulation and properties by Holmes, K. C., Trentham, D. R., Simmons, R., Somlyo, Avril V., Khromov, Alexander S., Webb, Martin R., Ferenczi, Michael A., Trentham, David R., He, Zhen-He, Sheng, Sitong, Shao, Zhifeng, Somlyo, Andrew P.

“…The relationship of the biochemical states to the mechanical events in contraction of smooth muscle cross–bridges is reviewed. These studies use direct…”
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The cAMP-responsive Rap1 Guanine Nucleotide Exchange Factor, Epac, Induces Smooth Muscle Relaxation by Down-regulation of RhoA Activity by Zieba, Bartosz J., Artamonov, Mykhaylo V., Jin, Li, Momotani, Ko, Ho, Ruoya, Franke, Aaron S., Neppl, Ronald L., Stevenson, Andra S., Khromov, Alexander S., Chrzanowska-Wodnicka, Magdalena, Somlyo, Avril V.

“…Agonist activation of the small GTPase, RhoA, and its effector Rho kinase leads to down-regulation of smooth muscle (SM) myosin light chain phosphatase…”
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Cryo-atomic Force Microscopy of Unphosphorylated and Thiophosphorylated Single Smooth Muscle Myosin Molecules by Sheng, Sitong, Gao, Yan, Khromov, Alexander S., Somlyo, Avril V., Somlyo, Andrew P., Shao, Zhifeng

“…The purpose of this study was to determine whether steric blockage of one head by the second head of native two-headed myosin was responsible for the…”
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Telokin mediates Ca2+-desensitization through activation of myosin phosphatase in phasic and tonic smooth muscle by Choudhury, Nandini, Khromov, Alexander S, Somlyo, Andrew P, Somlyo, Avril V

“…Telokin, a 17 kDa smooth muscle specific protein, consists of the C-terminal domain of MLCK, is phosphorylated by PKA and PKG at Ser13 in vivo (Wu et al…”
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Myosin Regulatory Light Chain Phosphorylation and Strain Modulate Adenosine Diphosphate Release from Smooth Muscle Myosin by Khromov, Alexander S., Webb, Martin R., Ferenczi, Michael A., Trentham, David R., Somlyo, Andrew P., Somlyo, Avril V.

“…The effects of myosin regulatory light chain (RLC) phosphorylation and strain on adenosine diphosphate (ADP) release from cross-bridges in phasic (rabbit…”
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Myosin Essential Light Chain Isoforms Modulate the Velocity of Shortening Propelled by Nonphosphorylated Cross-bridges by Matthew, John D., Khromov, Alexander S., Trybus, Kathleen M., Somlyo, Andrew P., Somlyo, Avril V.

“…The differential effects of essential light chain isoforms (LC17a and LC17b) on the mechanical properties of smooth muscle were determined by exchanging…”
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Photolytic Release of MgADP Reduces Rigor Force in Smooth Muscle by Khromov, Alexander S., Somlyo, Andrew P., Somlyo, Avril V.

“…Photolytic release of MgADP (25–300 μM) from caged ADP in permeabilized tonic (rabbit femoral artery-Rfa) and phasic (rabbit bladder-Rbl) smooth muscle in…”
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Kinetics of ADP Release From Cycling Cross Bridges In Contracting Skinned Cardiac Muscle Monitored With A Fluorescent Probe by Khromov, Alexander S., Webb, Martin R.

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The cAMP responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down regulation of RhoA activity by Zieba, Bartosz Jakub, Artamonov, Mykhaylo V, Jin, Li, Momotani, Ko, Ho, Ruoya, Franke, Aaron S, Neppl, Ronald L, Stevenson, Andra S, Khromov, Alexander S, Chrzanowska‐Wodnicka, Magdalena, Somlyo, Avril V

“…This study reports a new mechanism of cAMP mediated relaxation of Ca2+sensitized force, in smooth muscle (SM) through Epac, a GTP exchange factor for the small…”
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Telokin mediates Ca super(2+)-desensitization through activation of myosin phosphatase in phasic and tonic smooth muscle by Choudhury, Nandini, Khromov, Alexander S, Somlyo, Andrew P, Somlyo, Avril V

“…Telokin, a 17 kDa smooth muscle specific protein, consists of the C-terminal domain of MLCK, is phosphorylated by PKA and PKG at Ser13 in vivo (Wu et al…”
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Nucleotide binding by actomyosin as a determinant of relaxation kinetics of rabbit phasic and tonic smooth muscle by Khromov, A S, Somlyo, A V, Somlyo, A P

“…1. The apparent second-order rate constants (k+T) of ATP-induced cross-bridge detachment from rigor in the absence of Ca2+ were determined with laser flash…”
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