Search Results - "Khosla, Sundeep"

Estrogen Versus FSH Effects on Bone Metabolism: Evidence From Interventional Human Studies by Khosla, Sundeep

“…Abstract Provocative mouse studies and observational human data have generated considerable enthusiasm for modulating follicle-stimulating hormone (FSH) action…”
Get full text

Osteoporosis treatment: recent developments and ongoing challenges by Khosla, Sundeep, Hofbauer, Lorenz C

“…Osteoporosis is an enormous and growing public health problem. Once considered an inevitable consequence of ageing, it is now eminently preventable and…”
Get full text

Increasing Options for the Treatment of Osteoporosis by Khosla, Sundeep

“…More than a decade ago, receptor activator of nuclear factor-κB ligand (RANKL) was identified as the key molecule mediating osteoclast development, activity,…”
Get full text

The role of cellular senescence in ageing and endocrine disease by Khosla, Sundeep, Farr, Joshua N., Tchkonia, Tamara, Kirkland, James L.

“…With the ageing of the global population, interest is growing in the ‘geroscience hypothesis’, which posits that manipulation of fundamental ageing mechanisms…”
Get full text

Odanacatib: Location and timing are everything by Khosla, Sundeep

Get full text

Determinants of bone strength and quality in diabetes mellitus in humans by Farr, Joshua N, Khosla, Sundeep

“…Abstract There is growing evidence that the higher fracture rate observed in patients with type 2 diabetes mellitus (T2DM) is associated with normal, or even…”
Get full text

Skeletal changes through the lifespan—from growth to senescence by Farr, Joshua N., Khosla, Sundeep

“…Key Points Both peak bone mass attained during childhood and adolescent growth, and bone loss associated with senescence are major determinants of bone mass…”
Get full text

Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism by Weivoda, Megan M., Chew, Chee Kian, Monroe, David G., Farr, Joshua N., Atkinson, Elizabeth J., Geske, Jennifer R., Eckhardt, Brittany, Thicke, Brianne, Ruan, Ming, Tweed, Amanda J., McCready, Louise K., Rizza, Robert A., Matveyenko, Aleksey, Kassem, Moustapha, Andersen, Thomas Levin, Vella, Adrian, Drake, Matthew T., Clarke, Bart L., Oursler, Merry Jo, Khosla, Sundeep

“…Bone remodeling consists of resorption by osteoclasts followed by formation by osteoblasts, and osteoclasts are a source of bone formation-stimulating factors…”
Get full text

Managing fragility fractures during the COVID-19 pandemic by Napoli, Nicola, Elderkin, Ann L., Kiel, Douglas P., Khosla, Sundeep

“…The COVID-19 pandemic has broad implications for the care of patients with bone fragility. A dramatic surge in fractures and related mortality is expected in…”
Get full text

Cellular senescence and the skeleton: pathophysiology and therapeutic implications by Khosla, Sundeep, Farr, Joshua N, Monroe, David G

“…Cellular senescence is a fundamental aging mechanism that is currently the focus of considerable interest as a pathway that could be targeted to ameliorate…”
Get full text

Osteoporosis: now and the future by Rachner, Tilman D, MD, Khosla, Sundeep, Prof, Hofbauer, Lorenz C, Prof

“…Summary Osteoporosis is a common disease characterised by a systemic impairment of bone mass and microarchitecture that results in fragility fractures. With an…”
Get full text

Opportunistic application of phantom-less calibration methods for fracture risk prediction using QCT/FEA by Prado, Maria, Khosla, Sundeep, Chaput, Christopher, Giambini, Hugo

“…Objectives Quantitative computed tomography (QCT)–based finite element analysis (FEA) implements a calibration phantom to estimate bone mineral density (BMD)…”
Get full text

Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis by Khosla, Sundeep, Farr, Joshua N, Kirkland, James L

“…Abstract Context With the aging of the population and projected increase in osteoporotic fractures coupled with the declining use of osteoporosis medications,…”
Get full text

Bisphosphonates: Mechanism of Action and Role in Clinical Practice by Drake, Matthew T., MD, PhD, Clarke, Bart L., MD, Khosla, Sundeep, MD

“…Bisphosphonates are primary agents in the current pharmacological arsenal against osteoclast-mediated bone loss due to osteoporosis, Paget disease of bone,…”
Get full text

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span by Robbins, Paul D, Jurk, Diana, Khosla, Sundeep, Kirkland, James L, LeBrasseur, Nathan K, Miller, Jordan D, Passos, João F, Pignolo, Robert J, Tchkonia, Tamar, Niedernhofer, Laura J

“…Senescence is the consequence of a signaling mechanism activated in stressed cells to prevent proliferation of cells with damage. Senescent cells (Sncs) often…”
Get full text

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues by Saul, Dominik, Kosinsky, Robyn Laura, Atkinson, Elizabeth J., Doolittle, Madison L., Zhang, Xu, LeBrasseur, Nathan K., Pignolo, Robert J., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Jurk, Diana, Passos, João F., Hickson, LaTonya J., Xue, Ailing, Monroe, David G., Tchkonia, Tamara, Kirkland, James L., Farr, Joshua N., Khosla, Sundeep

“…Although cellular senescence drives multiple age-related co-morbidities through the senescence-associated secretory phenotype, in vivo senescent cell…”
Get full text

Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes by Sellmeyer, Deborah E, Civitelli, Roberto, Hofbauer, Lorenz C, Khosla, Sundeep, Lecka-Czernik, Beata, Schwartz, Ann V

“…Fracture risk is significantly increased in both type 1 and type 2 diabetes, and individuals with diabetes experience worse fracture outcomes than…”
Get full text

Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned by Drake, Matthew T, Clarke, Bart L, Oursler, Merry Jo, Khosla, Sundeep

“…Cathepsin K is a cysteine protease member of the cathepsin lysosomal protease family. Although cathepsin K is highly expressed in osteoclasts, lower levels of…”
Get full text

Is Nitroglycerin a Novel and Inexpensive Treatment for Osteoporosis? by Khosla, Sundeep

“…Current Food and Drug Administration approved medications in the US for prevention or treatment of osteoporosis fall into 1 of 2 categories. Thus, the prospect…”
Get full text

Identification of Senescent Cells in the Bone Microenvironment by Farr, Joshua N, Fraser, Daniel G, Wang, Haitao, Jaehn, Katharina, Ogrodnik, Mikolaj B, Weivoda, Megan M, Drake, Matthew T, Tchkonia, Tamara, LeBrasseur, Nathan K, Kirkland, James L, Bonewald, Lynda F, Pignolo, Robert J, Monroe, David G, Khosla, Sundeep

“…ABSTRACT Cellular senescence is a fundamental mechanism by which cells remain metabolically active yet cease dividing and undergo distinct phenotypic…”
Get full text