Search Results - "Khosla, Chaitan"

Evolution and Diversity of Assembly-Line Polyketide Synthases by Nivina, Aleksandra, Yuet, Kai P, Hsu, Jake, Khosla, Chaitan

“…Assembly-line polyketide synthases (PKSs) are among the most complex protein machineries known in nature, responsible for the biosynthesis of numerous…”
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Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial by Jagannathan, Prasanna, Andrews, Jason R., Bonilla, Hector, Hedlin, Haley, Jacobson, Karen B., Balasubramanian, Vidhya, Purington, Natasha, Kamble, Savita, de Vries, Christiaan R., Quintero, Orlando, Feng, Kent, Ley, Catherine, Winslow, Dean, Newberry, Jennifer, Edwards, Karlie, Hislop, Colin, Choong, Ingrid, Maldonado, Yvonne, Glenn, Jeffrey, Bhatt, Ami, Blish, Catherine, Wang, Taia, Khosla, Chaitan, Pinsky, Benjamin A., Desai, Manisha, Parsonnet, Julie, Singh, Upinder

“…Type III interferons have been touted as promising therapeutics in outpatients with coronavirus disease 2019 (COVID-19). We conducted a randomized,…”
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Biosynthesis of Aromatic Polyketides in Bacteria by Das, Abhirup, Khosla, Chaitan

“…Natural products, produced chiefly by microorganisms and plants, can be large and structurally complex molecules. These molecules are manufactured by cellular…”
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In vitro reconstitution and steady-state analysis of the fatty acid synthase from Escherichia coli by Yu, Xingye, Liu, Tiangang, Zhu, Fayin, Khosla, Chaitan

“…Microbial fatty acid derivatives are emerging as promising alternatives to fossil fuel derived transportation fuels. Among bacterial fatty acid synthases…”
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Structure and mechanism of assembly line polyketide synthases by Robbins, Thomas, Liu, Yu-Chen, Cane, David E, Khosla, Chaitan

“…[Display omitted] •High and low-resolution analysis yields insight into modular architecture of PKSs.•Energetic coupling of chain elongation controls…”
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Nonproteinogenic Amino Acid Building Blocks for Nonribosomal Peptide and Hybrid Polyketide Scaffolds by Walsh, Christopher T., O'Brien, Robert V., Khosla, Chaitan

“…Freestanding nonproteinogenic amino acids have long been recognized for their antimetabolite properties and tendency to be uncovered to reactive…”
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Overproduction of free fatty acids in E. coli: Implications for biodiesel production by Lu, Xuefeng, Vora, Harmit, Khosla, Chaitan

“…Whereas microbial fermentation processes for producing ethanol and related alcohol biofuels are well established, biodiesel (methyl esters of fatty acids) is…”
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Genomic mining and diversity of assembly line polyketide synthases by Kishore, Shreya, Khosla, Chaitan

“…Assembly line polyketide synthases (PKSs) are a large family of multifunctional enzymes responsible for synthesizing many medicinally relevant natural products…”
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Combinatorial biosynthesis of polyketides—a perspective by Wong, Fong T, Khosla, Chaitan

“…[Display omitted] ► New PKS gene clusters are being identified at an explosive rate. ► Understanding of PKS chemistry has improved, but its implications remain…”
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Cystamine and Disulfiram Inhibit Human Transglutaminase 2 via an Oxidative Mechanism by Palanski, Brad A, Khosla, Chaitan

“…The catalytic activity of transglutaminase 2 (TG2), a ubiquitously expressed mammalian enzyme, is regulated by multiple post-translational mechanisms. Because…”
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Quantitative analysis and engineering of fatty acid biosynthesis in E. coli by Liu, Tiangang, Vora, Harmit, Khosla, Chaitan

“…Fatty acids are central hydrocarbon intermediates in the biosynthesis of diesel from renewable sources. We have engineered an Escherichia coli cell line that…”
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An efficient urine peptidomics workflow identifies chemically defined dietary gluten peptides from patients with celiac disease by Palanski, Brad A., Weng, Nielson, Zhang, Lichao, Hilmer, Andrew J., Fall, Lalla A., Swaminathan, Kavya, Jabri, Bana, Sousa, Carolina, Fernandez-Becker, Nielsen Q., Khosla, Chaitan, Elias, Joshua E.

“…Celiac disease (CeD) is an autoimmune disorder induced by consuming gluten proteins from wheat, barley, and rye. Glutens resist gastrointestinal proteolysis,…”
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Prospects for Antibacterial Discovery and Development by Privalsky, Thomas M, Soohoo, Alexander M, Wang, Jinhua, Walsh, Christopher T, Wright, Gerard D, Gordon, Eric M, Gray, Nathanael S, Khosla, Chaitan

“…The rising prevalence of multidrug-resistant bacteria is an urgent health crisis that can only be countered through renewed investment in the discovery and…”
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Engineering the acyltransferase substrate specificity of assembly line polyketide synthases by Dunn, Briana J., Khosla, Chaitan

“…Polyketide natural products act as a broad range of therapeutics, including antibiotics, immunosuppressants and anti-cancer agents. This therapeutic diversity…”
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Biosynthesis and structure–activity relationships of the lipid a family of glycolipids by Xiao, Xirui, Sankaranarayanan, Karthik, Khosla, Chaitan

“…•The glycolipid Lipid A is the conserved, amphipathic moiety of LPS.•Lipid A binds to certain Toll like receptors and caspases with high affinity.•Bacteria…”
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Mapping the catalytic conformations of an assembly-line polyketide synthase module by Cogan, Dillon P, Zhang, Kaiming, Li, Xiuyuan, Li, Shanshan, Pintilie, Grigore D, Roh, Soung-Hun, Craik, Charles S, Chiu, Wah, Khosla, Chaitan

“…Assembly-line polyketide synthases, such as the 6-deoxyerythronolide B synthase (DEBS), are large enzyme factories prized for their ability to produce specific…”
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Discovery of Potent and Specific Dihydroisoxazole Inhibitors of Human Transglutaminase 2 by Klöck, Cornelius, Herrera, Zachary, Albertelli, Megan, Khosla, Chaitan

“…Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme that catalyzes the posttranslational modification of glutamine residues on protein or peptide…”
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Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification by Deans, Richard M, Morgens, David W, Ökesli, Ayşe, Pillay, Sirika, Horlbeck, Max A, Kampmann, Martin, Gilbert, Luke A, Li, Amy, Mateo, Roberto, Smith, Mark, Glenn, Jeffrey S, Carette, Jan E, Khosla, Chaitan, Bassik, Michael C

“…A combination of shRNA- and CRISPR-Cas9-based gene editing screens, corroborated by a metabolite suppression experiment identifies the pyrimidine biosynthesis…”
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Transglutaminase 2 undergoes a large conformational change upon activation by Pinkas, Daniel M, Strop, Pavel, Brunger, Axel T, Khosla, Chaitan

“…Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix…”
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Regulation of the activities of the mammalian transglutaminase family of enzymes by Klöck, Cornelius, Khosla, Chaitan

“…Mammalian transglutaminases catalyze post‐translational modifications of glutamine residues on proteins and peptides through transamidation or deamidation…”
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