The origin of segmentation motor activity in the intestine

The segmentation motor activity of the gut that facilitates absorption of nutrients was first described in the late 19th century, but the fundamental mechanisms underlying it remain poorly understood. The dominant theory suggests alternate excitation and inhibition from the enteric nervous system. H...

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Bibliographic Details
Published in:	Nature communications Vol. 5; no. 1; p. 3326
Main Authors:	Huizinga, Jan D., Chen, Ji-Hong, Fang Zhu, Yong, Pawelka, Andrew, McGinn, Ryan J., Bardakjian, Berj L., Parsons, Sean P., Kunze, Wolfgang A., Wu, Richard You, Bercik, Premysl, Khoshdel, Amir, Chen, Sifeng, Yin, Sheng, Zhang, Qian, Yu, Yuanjie, Gao, Qingmin, Li, Kongling, Hu, Xinghai, Zarate, Natalia, Collins, Phillip, Pistilli, Marc, Ma, Junling, Zhang, Ruixue, Chen, David
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 24-02-2014 Nature Publishing Group
Subjects:	14 14/19 631/378/1959/1315/1951 692/698/2741/520 Animals Enteric Nervous System - metabolism Enteric Nervous System - physiology Female Humanities and Social Sciences Interstitial Cells of Cajal - metabolism Interstitial Cells of Cajal - physiology Intestines - metabolism Intestines - physiology Mice Motor Activity - physiology multidisciplinary Myenteric Plexus - metabolism Myenteric Plexus - physiology Science Science (multidisciplinary)
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Summary:	The segmentation motor activity of the gut that facilitates absorption of nutrients was first described in the late 19th century, but the fundamental mechanisms underlying it remain poorly understood. The dominant theory suggests alternate excitation and inhibition from the enteric nervous system. Here we demonstrate that typical segmentation can occur after total nerve blockade. The segmentation motor pattern emerges when the amplitude of the dominant pacemaker, the slow wave generated by interstitial cells of Cajal associated with the myenteric plexus (ICC-MP), is modulated by the phase of induced lower frequency rhythmic transient depolarizations, generated by ICC associated with the deep muscular plexus (ICC-DMP), resulting in a waxing and waning of the amplitude of the slow wave and a rhythmic checkered pattern of segmentation motor activity. Phase–amplitude modulation of the slow waves points to an underlying system of coupled nonlinear oscillators originating in the networks of ICC. The segmentation motor activity of the small intestine is believed to be a result of alternating inhibitory and excitatory neural activity. Huizinga et al. show that the segmentation motor pattern is in fact a result of phase–amplitude interactions of slow-wave activities generated by two networks of interstitial cells of Cajal.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2041-1723 2041-1723
DOI:	10.1038/ncomms4326