Search Results - "Khoo, Yok Moi"

Dose- and schedule-dependent protective efficacy of celgosivir in a lethal mouse model for dengue virus infection informs dosing regimen for a proof of concept clinical trial by Watanabe, Satoru, Rathore, Abhay P.S., Sung, Cynthia, Lu, Fan, Khoo, Yok Moi, Connolly, John, Low, Jenny, Ooi, Eng Eong, Lee, How Sung, Vasudevan, Subhash G.

“…► Celgosivir protection against lethal dengue infection in mice is dose dependent. ► Celgosivir protection is 100% at 50mg/kg BID and 0% at 100mg/kg QD. ►…”
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Regulation of heart function by endogenous gaseous mediators-crosstalk between nitric oxide and hydrogen sulfide by Yong, Qian-Chen, Cheong, Jia Ling, Hua, Fei, Deng, Lih-Wen, Khoo, Yok Moi, Lee, How-Sung, Perry, Alexis, Wood, Mark, Whiteman, Matthew, Bian, Jin-Song

“…Both nitric oxide (NO) and hydrogen sulfide (H(2)S) are two important gaseous mediators regulating heart function. The present study examined the interaction…”
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Extended Evaluation of Virological, Immunological and Pharmacokinetic Endpoints of CELADEN: A Randomized, Placebo-Controlled Trial of Celgosivir in Dengue Fever Patients by Sung, Cynthia, Wei, Yuan, Watanabe, Satoru, Lee, How Sung, Khoo, Yok Moi, Fan, Lu, Rathore, Abhay P S, Chan, Kitti Wing-Ki, Choy, Milly M, Kamaraj, Uma S, Sessions, October M, Aw, Pauline, de Sessions, Paola F, Lee, Bernett, Connolly, John E, Hibberd, Martin L, Vijaykrishna, Dhanasekaran, Wijaya, Limin, Ooi, Eng Eong, Low, Jenny Guek-Hong, Vasudevan, Subhash G

“…CELADEN was a randomized placebo-controlled trial of 50 patients with confirmed dengue fever to evaluate the efficacy and safety of celgosivir (A study…”
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Genotype of human carbonyl reductase CBR3 correlates with doxorubicin disposition and toxicity by Fan, Lu, Goh, Boon-Cher, Wong, Chiung-Ing, Sukri, Norita, Lim, Siew-Eng, Tan, Sing-Huang, Guo, Jia-Yi, Lim, Robert, Yap, Hui-Ling, Khoo, Yok-Moi, Iau, Philip, Lee, How-Sung, Lee, Soo-Chin

“…OBJECTIVESDoxorubicin is a cytotoxic drug with potential for severe myelosuppression that is highly variable and poorly predictable. METHODSWe correlated CBR1…”
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Molecular and functional characterization of drug-metabolizing enzymes and transporter expression in the novel spontaneously immortalized human hepatocyte line HC-04 by Lim, Priscilla L.K., Tan, Weiqi, Latchoumycandane, Calivarathan, Mok, Wei Chuen, Khoo, Yok Moi, Lee, How Sung, Sattabongkot, Jetsumon, Beerheide, Walter, Lim, Seng Gee, Tan, Theresa M.C., Boelsterli, Urs A.

“…In toxicological research, immortalized human hepatocytes provide a useful alternative to primary hepatocytes because interindividual variability in the…”
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A high-performance liquid chromatography method for the quantification of cysmethynil, an inhibitor of isoprenylcysteine carboxylmethyl transferase, in mouse plasma by Wang, Mei, Khoo, Yok Moi, Zhou, Jin, Casey, Patrick, Lee, How Sung

“…Cysmethynil, a newly identified small molecule inhibitor of isoprenylcysteine carboxylmethyl transferase (Icmt) is involved in the post-translational…”
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A simple and sensitive high-performance liquid chromatographic method for quantification of PXD101, a histone deacetylase inhibitor in human plasma by NINGNING ZHANG, BOON CHER GOH, YOK MOI KHOO, YEO, Winnie, HOW SUNG LEE

“…PXD101, a new histone deacetylase inhibitor, is currently undergoing phase I/II clinical trials as an anticancer drug. This study describes a simple and…”
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Pharmacokinetics of propofol infusion in Asian patients undergoing coronary artery bypass grafting by Lee, H S, Khoo, Y M, Chua, B C, Ng, A S, Tan, S S, Chew, S L

“…The pharmacokinetics of propofol was studied in 11 Asian patients with fentanyl-isoflurane anaesthesia during cardiopulmonary bypass (CPB) and undergoing…”
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Caffeine in apnoeic Asian neonates: a sparse data analysis by Lee, How Sung, Khoo, Yok Moi, Chirino‐Barcelo, Yazmin, Tan, Kim Leong, Ong, Dorothy

“…Aims  To monitor plasma caffeine concentrations and adverse effects and to study the pharmacokinetics of caffeine in neonatal apnoea in the local Asian…”
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Phenotyping CYP3A using midazolam in cancer and noncancer Asian patients by Lee, How Sung, Goh, Boon Cher, Fan, Lu, Khoo, Yok Moi, Wang, Lingzhi, Lim, Robert, Ong, Ai Bee, Chua, Charlotte

“…Aims   To investigate CYP3A activity in cancer and noncancer Asian patients using midazolam and to reveal possible alternative traits for phenotyping CYP3A…”
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Clinical evaluation and serum concentration of zuclopenthixol acetate in psychotic Asian patients: a single-dose preliminary study by Tan, C H, Low, B L, Ng, L L, Khoo, Y M, Lee, H S

“…Nineteen acutely disturbed psychotic Asian patients were treated with a single intramuscular injection of 50 mg of zuclopenthixol acetate in Viscoleo. Patients…”
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Clinical evaluation and plasma clozapine concentrations in Chinese patients with schizophrenia by CHONG, S.-A, TAN, C.-H, KHOO, Y.-M, LEE, H.-S, WONG, K.-E, NGUI, F, WINSLOW, M

“…The relationships between clozapine dosages, plasma concentrations, and clinical responses in Chinese schizophrenics were studied. Fourteen…”
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Serum concentrations and clinical effects of risperidone in schizophrenic patients in Singapore—a preliminary report by Lee, How Sung, Tan, Chay Hoon, Khoo, Yok Moi, Chee, Kuan Tsee, Wong, Kim Eng, Chong, Siow Ann, Mahendran, Rathi, Yap, Hwa Ling, Low, Bee Lee, Choo, Chih Huei, Chan, Angelina

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Serum and urine risperidone concentrations in an acute overdose by Lee, H S, Tan, C H, Au, L S, Khoo, Y M

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Disposition of intravenous metronidazole in Asian surgical patients by TI, T.-Y, LEE, H.-S, KHOO, Y.-M

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Nimesulide-induced hepatic mitochondrial injury in heterozygous Sod2 +/− mice by Ong, Michie M.K., Wang, Audrey S., Leow, Koon Yeow, Khoo, Yok Moi, Boelsterli, Urs A.

“…Nimesulide, a preferential COX-2 inhibitor, has been associated with rare idiosyncratic hepatotoxicity. The underlying mechanisms of liver injury are unknown,…”
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Simple HPLC Determination of the Concentrations of Epiroprim in the Serum and Brains of Mice by Lee, How Sung, Chang, Hernan R., Khoo, Yok Moi

“…Epiroprim, an analogue of trimethoprim, has been shown to potentiate the efficacy of dapsone in experimental parasitic infections. A simple and accurate HPLC…”
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