Search Results - "Khoo, Keith K"

The thermodynamics of Pr55Gag-RNA interaction regulate the assembly of HIV by Tanwar, Hanumant S, Khoo, Keith K, Garvey, Megan, Waddington, Lynne, Leis, Andrew, Hijnen, Marcel, Velkov, Tony, Dumsday, Geoff J, McKinstry, William J, Mak, Johnson

“…The interactions that occur during HIV Pr55Gag oligomerization and genomic RNA packaging are essential elements that facilitate HIV assembly. However,…”
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Potassium Channel Modulation by a Toxin Domain in Matrix Metalloprotease 23 by Rangaraju, Srikant, Khoo, Keith K., Feng, Zhi-Ping, Crossley, George, Nugent, Daniel, Khaytin, Ilya, Chi, Victor, Pham, Cory, Calabresi, Peter, Pennington, Michael W., Norton, Raymond S., Chandy, K. George

“…Peptide toxins found in a wide array of venoms block K+ channels, causing profound physiological and pathological effects. Here we describe the first…”
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Plasma Protein Binding Structure–Activity Relationships Related to the N‑Terminus of Daptomycin by Schneider, Elena K, Huang, Johnny X, Carbone, Vincenzo, Han, Meiling, Zhu, Yan, Nang, Sue, Khoo, Keith K, Mak, Johnson, Cooper, Matthew A, Li, Jian, Velkov, Tony

“…Daptomycin is a lipopeptide antibiotic that is highly bound to plasma proteins. To date, the plasma components and structure–activity relationships responsible…”
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Intrastructural Help: Harnessing T Helper Cells Induced by Licensed Vaccines for Improvement of HIV Env Antibody Responses to Virus-Like Particle Vaccines by Elsayed, Hassan, Nabi, Ghulam, McKinstry, William J, Khoo, Keith K, Mak, Johnson, Salazar, Andres M, Tenbusch, Matthias, Temchura, Vladimir, Überla, Klaus

“…Induction of persistent antibody responses by vaccination is generally thought to depend on efficient help by T follicular helper cells. Since the T helper…”
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Correction for Elsayed et al., "Intrastructural Help: Harnessing T Helper Cells Induced by Licensed Vaccines for Improvement of HIV Env Antibody Responses to Virus-Like Particle Vaccines" by Elsayed, Hassan, Nabi, Ghulam, McKinstry, William J, Khoo, Keith K, Mak, Johnson, Salazar, Andres M, Tenbusch, Matthias, Temchura, Vladimir, Überla, Klaus

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How an intrinsic ligand tunes the activity of a potassium channel by Khoo, Keith K, Pless, Stephan A

“…Khoo and Pless examine new work that provides mechanistic insight into the role of the intrinsic ligand in KCNH ion channels.​…”
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A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases by Rashid, M. Harunur, Huq, Redwan, Tanner, Mark R., Chhabra, Sandeep, Khoo, Keith K., Estrada, Rosendo, Dhawan, Vikas, Chauhan, Satendra, Pennington, Michael W., Beeton, Christine, Kuyucak, Serdar, Norton, Raymond S.

“…HsTX1 toxin, from the scorpion Heterometrus spinnifer , is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. Here we describe…”
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Distinct Disulfide Isomers of μ‑Conotoxins KIIIA and KIIIB Block Voltage-Gated Sodium Channels by Khoo, Keith K, Gupta, Kallol, Green, Brad R, Zhang, Min-Min, Watkins, Maren, Olivera, Baldomero M, Balaram, Padmanabhan, Yoshikami, Doju, Bulaj, Grzegorz, Norton, Raymond S

“…In the preparation of synthetic conotoxins containing multiple disulfide bonds, oxidative folding can produce numerous permutations of disulfide bond…”
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Lactam-Stabilized Helical Analogues of the Analgesic μ-Conotoxin KIIIA by Khoo, Keith K, Wilson, Michael J, Smith, Brian J, Zhang, Min-Min, Gulyas, Joszef, Yoshikami, Doju, Rivier, Jean E, Bulaj, Grzegorz, Norton, Raymond S

“…μ-Conotoxin KIIIA (μ-KIIIA) blocks mammalian voltage-gated sodium channels (VGSCs) and is a potent analgesic following systemic administration in mice…”
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A Helical Conotoxin from Conus imperialis Has a Novel Cysteine Framework and Defines a New Superfamily by Ye, Mingyu, Khoo, Keith K., Xu, Shaoqiong, Zhou, Mi, Boonyalai, Nonlawat, Perugini, Matthew A., Shao, Xiaoxia, Chi, Chengwu, Galea, Charles A., Wang, Chunguang, Norton, Raymond S.

“…Cone snail venoms are a rich source of peptides, many of which are potent and selective modulators of ion channels and receptors. Here we report the isolation…”
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Structure of the Analgesic μ-Conotoxin KIIIA and Effects on the Structure and Function of Disulfide Deletion by Khoo, Keith K, Feng, Zhi-Ping, Smith, Brian J, Zhang, Min-Min, Yoshikami, Doju, Olivera, Baldomero M, Bulaj, Grzegorz, Norton, Raymond S

“…μ-Conotoxin μ-KIIIA, from Conus kinoshitai, blocks mammalian neuronal voltage-gated sodium channels (VGSCs) and is a potent analgesic following systemic…”
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The C-terminal p6 domain of the HIV-1 Pr55Gag precursor is required for specific binding to the genomic RNA by Dubois, Noé, Khoo, Keith K., Ghossein, Shannon, Seissler, Tanja, Wolff, Philippe, McKinstry, William J., Mak, Johnson, Paillart, Jean-Christophe, Marquet, Roland, Bernacchi, Serena

“…The Pr55 Gag precursor specifically selects the HIV-1 genomic RNA (gRNA) from a large excess of cellular and partially or fully spliced viral RNAs and drives…”
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The C-terminal p6 domain of the HIV-1 Pr55 Gag precursor is required for specific binding to the genomic RNA by Dubois, Noé, Khoo, Keith K, Ghossein, Shannon, Seissler, Tanja, Wolff, Philippe, McKinstry, William J, Mak, Johnson, Paillart, Jean-Christophe, Marquet, Roland, Bernacchi, Serena

“…The Pr55 precursor specifically selects the HIV-1 genomic RNA (gRNA) from a large excess of cellular and partially or fully spliced viral RNAs and drives the…”
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A Semi-Synthetic Approach to Engineer Ligand- and Voltage-Gated Ion Channels in Live Cells by Khoo, Keith K., Galleano, Iacopo, Pless, Stephan A.

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Interplay of Nav1.5 Disease-Causing Mutations and Phosphorylation Revealed by Protein Semi-Synthesis and Molecular Dynamics Simulations by Galleano, Iacopo, Harms, Hendrik, Choudhury, Koushik, Khoo, Keith K., Delemotte, Lucie, Pless, Stephan A.

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The thermodynamics of Pr55.sup.Gag-RNA interaction regulate the assembly of HIV by Tanwar, Hanumant S, Khoo, Keith K, Garvey, Megan, Waddington, Lynne, Leis, Andrew, Hijnen, Marcel, Velkov, Tony, Dumsday, Geoff J, McKinstry, William J, Mak, Johnson

“…The interactions that occur during HIV Pr55.sup.Gag oligomerization and genomic RNA packaging are essential elements that facilitate HIV assembly. However,…”
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Structure of the Analgesic m-Conotoxin KIIIA and Effects on the Structure and Function of Disulfide Deletion by Khoo, Keith K, Feng, Zhi-Ping, Smith, Brian J, Zhang, Min-Min, Yoshikami, Doju, Olivera, Baldomero M, Bulaj, Grzegorz, Norton, Raymond S

“…*m-Conotoxin *m-KIIIA, from Conus kinoshitai, blocks mammalian neuronal voltage-gated sodium channels (VGSCs) and is a potent analgesic following systemic…”
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Protein semisynthesis underscores the role of a conserved lysine in activation and desensitization of acid-sensing ion channels by Sarkar, Debayan, Galleano, Iacopo, Heusser, Stephanie Andrea, Ou, Sofie Yuewei, Uzun, Gül Refika, Khoo, Keith K, van der Heden van Noort, Gerbrand Jan, Harrison, Joseph Scott, Pless, Stephan Alexander

“…Acid-sensing ion channels (ASICs) are trimeric ion channels that open a cation-conducting pore in response to proton binding. Excessive ASIC activation during…”
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