Search Results - "Khoo, K.H"

Nitro–Fatty Acids Reduce Atherosclerosis in Apolipoprotein E–Deficient Mice by Rudolph, Tanja K, Rudolph, Volker, Edreira, Martin M, Cole, Marsha P, Bonacci, Gustavo, Schopfer, Francisco J, Woodcock, Steven R, Franek, Andreas, Pekarova, Michaela, Khoo, Nicholas K.H, Hasty, Alyssa H, Baldus, Stephan, Freeman, Bruce A

“…OBJECTIVE—Inflammatory processes and foam cell formation are key determinants in the initiation and progression of atherosclerosis. Electrophilic nitro–fatty…”
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Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice by Chartoumpekis, Dionysios V, Palliyaguru, Dushani L, Wakabayashi, Nobunao, Khoo, Nicholas K.H, Schoiswohl, Gabriele, O'Doherty, Robert M, Kensler, Thomas W

“…Abstract Objective The Notch family of intermembrane receptors is highly conserved across species and is involved in cell fate and lineage control. Previous…”
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Obesity-induced tissue free radical generation: An in vivo immuno-spin trapping study by Khoo, Nicholas K.H., Cantu-Medellin, Nadiezhda, Devlin, Jason E., St. Croix, Claudette M., Watkins, Simon C., Fleming, Alexander M., Champion, Hunter C., Mason, Ronald P., Freeman, Bruce A., Kelley, Eric E.

“…Assessment of tissue free radical production is routinely accomplished by measuring secondary by-products of redox reactions and/or diminution of key…”
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Conjugated Linoleic Acid Is a Preferential Substrate for Fatty Acid Nitration by Bonacci, Gustavo, Baker, Paul R.S., Salvatore, Sonia R., Shores, Darla, Khoo, Nicholas K.H., Koenitzer, Jeffrey R., Vitturi, Dario A., Woodcock, Steven R., Golin-Bisello, Franca, Cole, Marsha P., Watkins, Simon, St. Croix, Claudette, Batthyany, Carlos I., Freeman, Bruce A., Schopfer, Francisco J.

“…The oxidation and nitration of unsaturated fatty acids by oxides of nitrogen yield electrophilic derivatives that can modulate protein function via…”
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Electrophilic nitro-oleic acid reverses obesity-induced hepatic steatosis by Khoo, Nicholas K H, Fazzari, Marco, Chartoumpekis, Dionysios V, Li, Lihua, Guimaraes, Danielle Aparecida, Arteel, Gavin E, Shiva, Sruti, Freeman, Bruce A

“…Non-alcoholic fatty liver disease (NAFLD) is linked to obesity and insulin resistance and is the most prevalent chronic liver disease. During the development…”
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Activation of vascular endothelial nitric oxide synthase and heme oxygenase-1 expression by electrophilic nitro-fatty acids by Khoo, Nicholas K.H., Rudolph, Volker, Cole, Marsha P., Golin-Bisello, Franca, Schopfer, Francisco J., Woodcock, Steven R., Batthyany, Carlos, Freeman, Bruce A.

“…Reactive oxygen species mediate a decrease in nitric oxide (NO) bioavailability and endothelial dysfunction, with secondary oxidized and nitrated by-products…”
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Differential activation of catalase expression and activity by PPAR agonists: implications for astrocyte protection in anti-glioma therapy by Khoo, Nicholas K H, Hebbar, Sachin, Zhao, Weiling, Moore, Steven A, Domann, Frederick E, Robbins, Mike E

“…Glioma survival is dismal, in part, due to an imbalance in antioxidant expression and activity. Peroxisome proliferator-activated receptor (PPAR) agonists have…”
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Obese female mice do not exhibit overt hyperuricemia despite hepatic steatosis and impaired glucose tolerance by Lewis, Sara E., Li, Lihua, Fazzari, Marco, Salvatore, Sonia R., Li, Jiang, Hileman, Emily A., Maxwell, Brooke A., Schopfer, Francisco J., Arteel, Gavin E., Khoo, Nicholas K.H., Kelley, Eric E.

“…•Recent publications report a tight correlation between obesity and elevated circulating uric acid levels (hyperuricemia). However, nearly all preclinical work…”
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Moderate hypoxia induces xanthine oxidoreductase activity in arterial endothelial cells by Kelley, Eric E., Hock, Thomas, Khoo, Nicholas K.H., Richardson, Gloria R., Johnson, Kamorris K., Powell, Pamela C., Giles, Gregory I., Agarwal, Anupam, Lancaster, Jack R., Tarpey, Margaret M.

“…Xanthine oxidoreductase (XOR) activity has been previously noted to be responsive to changes in O 2 tension. While prior studies have focused on the extremes…”
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Covalent Peroxisome Proliferator-activated Receptor γ Adduction by Nitro-fatty Acids: SELECTIVE LIGAND ACTIVITY AND ANTI-DIABETIC SIGNALING ACTIONS by Schopfer, Francisco J, Cole, Marsha P, Groeger, Alison L, Chen, Chen-Shan, Khoo, Nicholas K.H, Woodcock, Steven R, Golin-Bisello, Franca, Motanya, U. Nkiru, Li, Yong, Zhang, Jifeng, Garcia-Barrio, Minerva T, Rudolph, Tanja K, Rudolph, Volker, Bonacci, Gustavo, Baker, Paul R.S, Xu, H. Eric, Batthyany, Carlos I, Chen, Y. Eugene, Hallis, Tina M, Freeman, Bruce A

“…The peroxisome proliferator-activated receptor-γ (PPARγ) binds diverse ligands to transcriptionally regulate metabolism and inflammation. Activators of PPARγ…”
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Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling by Al Ghouleh, Imad, Khoo, Nicholas K.H., Knaus, Ulla G., Griendling, Kathy K., Touyz, Rhian M., Thannickal, Victor J., Barchowsky, Aaron, Nauseef, William M., Kelley, Eric E., Bauer, Phillip M., Darley-Usmar, Victor, Shiva, Sruti, Cifuentes-Pagano, Eugenia, Freeman, Bruce A., Gladwin, Mark T., Pagano, Patrick J.

“…Reactive oxygen species (ROS) are involved in numerous physiological and pathophysiological responses. Increasing evidence implicates ROS as signaling…”
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Nitro-Fatty Acid Inhibition of Neointima Formation After Endoluminal Vessel Injury by Cole, Marsha P, Rudolph, Tanja K, Khoo, Nicholas K.H, Motanya, Uche N, Golin-Bisello, Franca, Wertz, Jeffrey W, Schopfer, Francisco J, Rudolph, Volker, Woodcock, Steven R, Bolisetty, Subhashini, Ali, Muhammad S, Zhang, Jifeng, Chen, Y Eugene, Agarwal, Anupam, Freeman, Bruce A, Bauer, Philip M

“…RATIONALE:Fatty acid nitroalkenes are endogenously generated electrophilic byproducts of nitric oxide and nitrite-dependent oxidative inflammatory reactions…”
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The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s) by STEPHENS, L, RADENBERG, T, THIEL, U, VOGEL, G, KAY-HOOI KHOO, DELL, A, JACKSON, T. R, HAWKINS, P. T, MAYR, G. W

“…A new class of inositol phosphates containing energy-rich pyrophosphoryl residues has been characterized. D/L-1-Diphosphoinositol pentakisphosphate(s) and…”
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The Transcriptomic Response of the Murine Thyroid Gland to Iodide Overload and the Role of the Nrf2 Antioxidant System by Chartoumpekis, Dionysios V., Ziros, Panos G., Georgakopoulos-Soares, Ilias, Smith, Adam A. T., Marques, Ana Claudia, Ibberson, Mark, A. Kopp, Peter, Habeos, Ioannis, Trougakos, Ioannis P., Khoo, Nicholas K. H., Sykiotis, Gerasimos P.

“…Background: Thyroid follicular cells have physiologically high levels of reactive oxygen species because oxidation of iodide is essential for the iodination of…”
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Helimagnetic order in bulk MnSi and CoSi/MnSi superlattices by Loh, G.C., Khoo, K.H., Gan, C.K.

“…Skyrmions are nanoscopic whirls of spins that reside in chiral magnets. It is only fairly recent that a plethora of applications for these quasiparticles…”
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Structural studies on the bacterial lyase-resistant tetrasaccharides derived from the antithrombin III-binding site of porcine intestinal heparin by YAMADA, S, YOSHIDA, K, SUGIURA, M, SUGAHARA, K, KAY-HOOI KHOO, MORRIS, H. R, DELL, A

“…Three discrete tetrasaccharide structures which are resistant to Flavobacterium heparinase and heparitinases I and II were isolated from porcine intestinal…”
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Structural studies of a novel type of pentaantennary large glycan unit in the fertilization-associated carbohydrate-rich glycopeptide isolated from the fertilized eggs of Oryzias latipes by TAGUCHI, T, SEKO, A, KITAJIMA, K, MUTO, Y, INOUE, S, KAY-HOOI KHOO, MORRIS, H. R, DELL, A, INOUE, Y

“…In a previous report (Kitajima, K., Inoue, S., and Inoue, Y. (1989) Dev. Biol. 132, 544-553), we found the presence of a heavily glycosylated polyprotein,…”
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Structural studies of a novel type of tetraantennary sialoglycan unit in a carbohydrate-rich glycopeptide isolated from the fertilized eggs of Indian Medaka fish, Oryzias melastigma by TAGUCHI, T, SEKO, A, KITAJIMA, K, INOUE, S, IWAMATSU, T, KAY-HOOI KHOO, MORRIS, H. R, DELL, A, INOUE, Y

“…A novel carbohydrate-rich sialoglycopolyprotein of apparent molecular mass approximately 7000 Da was isolated from the fertilized eggs of the Medaka fish…”
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Nitro-Fatty Acid Logistics: Formation, Biodistribution, Signaling, and Pharmacology by Schopfer, Francisco J., Khoo, Nicholas K.H.

“…In addition to supporting cellular energetic demands and providing building blocks for lipid synthesis, fatty acids (FAs) are precursors of potent signaling…”
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Hydrogen peroxide is the major oxidant product of xanthine oxidase by Kelley, Eric E., Khoo, Nicholas K.H., Hundley, Nicholas J., Malik, Umair Z., Freeman, Bruce A., Tarpey, Margaret M.

“…Xanthine oxidase (XO) is a critical source of reactive oxygen species (ROS) in inflammatory disease. Focus, however, has centered almost exclusively on…”
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