Search Results - "Khong, Trong Quan"
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Cucurbitane Triterpenoids from the Fruits of Momordica Charantia Improve Insulin Sensitivity and Glucose Homeostasis in Streptozotocin‐Induced Diabetic Mice
Published in Molecular nutrition & food research (01-04-2018)“…Scope Momordica charantia (M. charantia) has antidiabetic effects, and cucurbitane‐type triterpenoid is one of the compounds of M. charantia. This study aims…”
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Accelerated degradation of cFLIPL and sensitization of the TRAIL DISC-mediated apoptotic cascade by pinoresinol, a lignan isolated from Rubia philippinensis
Published in Scientific reports (18-09-2019)“…Plant-derived lignans have numerous biological effects including anti-tumor and anti-inflammatory activities. Screening of purified constituents of Rubia…”
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Oleanane triterpenoids from Rubia philippinensis and their inhibitory effect on 20-HETE synthesis
Published in Natural product research (01-04-2021)“…A new oleanane triterpenoid (2) was isolated from the roots of Rubia philippinensis. The structure of 2 was determined by analysis of HRMS and NMR data and…”
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Extract of Curcuma zedoaria R. prevents atherosclerosis in apolipoprotein E-deficient mice
Published in Nutrition research and practice (01-06-2021)“…BACKGROUND/OBJECTIVESCurcuma zedoaria R. (Zingiberaceae) has been used to treat headache, fever, and hypertension-related symptoms in Asian countries,…”
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Lucidin 3-methyl ether from Rubia philippinensis suppresses the proliferation of multiple myeloma cells through the promotion of β-catenin degradation
Published in Phytomedicine (Stuttgart) (01-05-2022)“…Constitutive accumulation of β-catenin has been frequently observed in multiple myeloma. Extracts from genus Rubia plants exhibit cytotoxic activity against…”
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Paratrimerins J–Y, Dimeric Coumarins Isolated from the Stems of Paramignya trimera
Published in Journal of natural products (Washington, D.C.) (26-02-2021)“…Paratrimerins J–Y (1–13 and 16–18), new dimeric coumarins, were obtained from the EtOH(aq) extract of the stems of Paramignya trimera (Rutaceae) utilizing…”
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Attenuation of inflammatory responses by (+)-syringaresinol via MAP-Kinase-mediated suppression of NF-κB signaling in vitro and in vivo
Published in Scientific reports (15-06-2018)“…We examined the anti-inflammatory effects of (+)-syringaresinol (SGRS), a lignan isolated from Rubia philippinensis , in lipopolysaccharide (LPS)-stimulated…”
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Phytochemical profile of Syzygium formosum (Wall.) Masam leaves using HPLC–PDA–MS/MS and a simple HPLC–ELSD method for quality control
Published in Journal of pharmaceutical and biomedical analysis (10-05-2019)“…[Display omitted] The first report concerning the detailed phytochemical profile of Syzygium formosum leaves using HPLC–PDA–MS/MS. Seventeen compounds are…”
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Activation of the p53 pathway with digiferrol isolated from Rubia philippinensis induces cell cycle arrest, apoptosis, and autophagy in colon cancer cells
Published in Food and chemical toxicology (01-08-2018)“…•Digiferrol is a novel activator of the p53 pathway.•Digiferrol stabilizes p53 protein in the nucleus.•Digiferrol induces cell cycle arrest at G2/M phase in…”
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Antioxidant efficacy and the upregulation of Nrf2-mediated HO-1 expression by (+)-lariciresinol, a lignan isolated from Rubia philippinensis, through the activation of p38
Published in Scientific reports (05-04-2017)“…The aim of the present study was to examine the antioxidative activity of (+)-lariciresinol (LRSL), an optically active lignan isolated from Rubia…”
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Rubiarbonone C inhibits platelet‐derived growth factor‐induced proliferation and migration of vascular smooth muscle cells through the focal adhesion kinase, MAPK and STAT3 Tyr705 signalling pathways
Published in British journal of pharmacology (01-11-2017)“…Background and Purpose The proliferation and migration of vascular smooth muscle cells (VSMCs) induced by platelet‐derived growth factor (PDGF) are important…”
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Arborinane Triterpenoids from Rubia philippinensis Inhibit Proliferation and Migration of Vascular Smooth Muscle Cells Induced by the Platelet-Derived Growth Factor
Published in Journal of natural products (Washington, D.C.) (28-10-2016)“…The abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are associated with cardiovascular diseases and related complications. Such…”
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NMR-Based Investigation of Hydrogen Bonding in a Dihydroanthracen-1(4H)one from Rubia philippinensis and Its Soluble Epoxide Hydrolase Inhibitory Potential
Published in Journal of natural products (Washington, D.C.) (26-11-2018)“…Hydrogen bonding is a vital feature of a large ensemble of chemical structures. Soluble epoxide hydrolase (sEH) has been targeted for development of the…”
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An optimized HPLC-UV method for quantitatively determining sesquiterpenes in Nardostachyos Radix et Rhizoma
Published in Journal of pharmaceutical and biomedical analysis (25-10-2017)“…[Display omitted] •Simultaneous HPLC method was developed for desoxo-narchinol A, nardosinonediol and nardosinone.•Sample preparation was optimized by response…”
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Asymmetric dimeric ent-kauranoids from Croton tonkinensis and their cytotoxicity
Published in Tetrahedron letters (18-04-2019)“…[Display omitted] •Two novel asymmetric dimeric ent-kauranoids were isolated from Croton tonkinensis.•A plausible biosynthetic pathway for two new dimers was…”
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Anthraquinone-type inhibitor of α-glucosidase enhances glucose uptake by activating an insulin-like signaling pathway in C2C12 myotubes
Published in Food and chemical toxicology (01-07-2019)“…This study assesses the ability of anthraquinone derivative, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTAQ) to decrease postprandial hyperglycemia or…”
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Cytotoxic properties of the anthraquinone derivatives isolated from the roots of Rubia philippinensis
Published in BMC complementary and alternative medicine (03-07-2018)“…Cancer is one of the most frequently occurring diseases and is the second leading cause of death worldwide. In this study, anthraquinone derivatives (Compounds…”
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Discovery of rubiarbonone C as a selective inhibitor of cytochrome P450 4F enzymes
Published in Archives of toxicology (01-11-2018)“…Cytochrome P450 (CYP) enzymes, particularly CYP4A/4F, are the major ω-hydroxylases of arachidonic acid (AA) that can produce 20-hydroxyeicosatetraenoic acid…”
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Configurational Assignment of a Flexible Benzo[g]isochromene Stereodiad from Rubia philippinensis and Inhibition of Soluble Epoxide Hydrolase Activity
Published in Journal of natural products (Washington, D.C.) (24-09-2021)“…A new benzo[g]isochromene possessing a conformationally mobile moiety was identified from Rubia philippinensis. The 2D structure was established utilizing…”
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8-Geranylumbelliferone isolated from Paramignya trimera triggers RIPK1/RIPK3-dependent programmed cell death upon TNFR1 ligation
Published in Biochemical pharmacology (01-10-2021)“…[Display omitted] In tumor necrosis factor (TNF) signaling, IκB kinase (IKK) complex-mediated activation of NF-κB is a well-known protective mechanism against…”
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