Search Results - "Khomutov, M. A"

Aminooxy analog of histamine is an efficient inhibitor of mammalian L-histidine decarboxylase: combined in silico and experimental evidence by Castro-Oropeza, R, Pino-Ángeles, A, Khomutov, M. A, Urdiales, J. L, Moya-García, A. A, Vepsäläinen, J, Persson , L, Sarabia , F, Khomutov, A, Sánchez-Jiménez, F

“…Histamine plays highlighted roles in the development of many common, emergent and rare diseases. In mammals, histamine is formed by decarboxylation of…”
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Aminooxy adsorbents derived from sephareose and toyopearl by Khomutov, M. A., Solyev, P. N., Kochetkov, S. N., Khomutov, A. R.

“…Convenient synthetic schemes being suitable for the preparation of aminooxy-Sepharose and hydroxylamine-containing Toyopearl with capacity of 0.35–0.015 mmols…”
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Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus by Korovina, A. N., Tunitskaya, V. L., Khomutov, M. A., Simonian, A. R., Khomutov, A. R., Ivanov, A. V., Kochetkov, S. N.

“…Influence of the biogenic polyamines spermine, spermidine, and putrescine as well as their derivatives on the replication enzymes of hepatitis C virus (HCV)…”
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Convenient syntheses of phosphinic analogues of γ-aminobutyric- and glutamic acids by Khomutov, M. A., Formanovsky, A. A., Mikhura, I. V., Vepsalainen, J., Kochetkov, S. N., De Biase, D., Khomutov, A. R.

“…Three-steps, one-pot synthesis of 2-amino-4-(hydroxyphosphinyl)butyric acid from dibutyl ester of vinylphosphinic acid was carried out with an overall yield of…”
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Synthesis of 2-Methylidene Spermidine and its N1-Acetylated Derivative by Khomutov, M. A., Khomutov, A. R.

“…— Simple and practical synthetic protocols have been developed for the preparation of earlier unknown 2-methylidene derivatives of spermidine and N 1…”
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Interaction of DNA Methyltransferase Dnmt3a with Phosphorus Analogs of S-Adenosylmethionine and S-Adenosylhomocysteine by Filonov, V. L., Khomutov, M. A., Sergeev, A. V., Khandazhinskaya, A. L., Kochetkov, S. N., Gromova, E. S., Khomutov, A. R.

“…Enzymatic methyltransferase reactions are of crucial importance for cell metabolism. S -Adenosyl- L -methionine (AdoMet) is a main donor of the methyl group…”
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C-Methylated Analogs of Spermine and Spermidine: Synthesis and Biological Activity by Khomutov, M. A., Mikhura, I. V., Kochetkov, S. N., Khomutov, A. R.

“…— Biogenic polyamines spermine and spermidine are present in eukaryotic cells in micro- and millimolar concentrations, that determines the multiplicity of…”
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Identification of a novel substrate-derived spermine oxidase inhibitor by Dunston, T. T., Khomutov, M. A., Gabelli, S. B., Stewart, T. M., Foley, J. R., Kochetkov, S. N., Khomutov, A. R., Casero Jr, R. A.

“…Homeostasis of the biogenic polyamines spermine (Spm) and spermidine (Spd), present in M-mM concentrations in all eukaryotic cells, is precisely regulated by…”
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Leishmania donovani: Structural insignt in the recognition of C-methylated analogues of spermidine as natural polyamines by Mandal, S., Khomutov, M. A., Simonian, A. R., Kochetkov, S. N., Madhubala, R.

“…The ability of α-, ν-, γ- and ω-methylated spermidine analogues to restore the growth of L. donovani promastigotes that were depleted of putrescine and…”
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Methylated analogs of spermine and spermidine as tools to investigate cellular functions of polyamines and enzymes of their metabolism by Khomutov, A. R, Keinanen, T. A, Grigorenko, N. A, Hyvonen, M. T, Uimari, A, Pietila, M, Cerrada-Gimenez, M, Simonian, A. R, Khomutov, M. A, Vepsalainen, J, Alhonen, L, Janne, J

“…Biogenic amines spermine (Spm) and spermidine (Spd) are essential for cell growth. Polyamine analogs are widely used to investigate the enzymes of polyamine…”
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Hydroxylamine derivatives for regulation of spermine and spermidine metabolism by Khomutov, M. A., Weisell, J., Hyvönen, M., Keinänen, T. A., Vepsäläinen, J., Alhonen, L., Khomutov, A. R., Kochetkov, S. N.

“…The biogenic polyamines spermine, spermidine, and their precursor putrescine are present in micro-to-millimolar concentrations in all cell types and are…”
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Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase by Grigorenko, N. A., Khomutov, M. A., Simonian, A. R., Kochetkov, S. N., Khomutov, A. R.

“…Earlier unknown 1,12-diamino-2,11-bis(methylidene)-4,9-diazadodecane, which may be considered as an enzyme-activated inhibitor of spermine oxidase, was…”
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Novel hydroxylamine-containing analogues of 1-guanidino-7-aminoheptane (GC7), an effective inhibitor of deoxyhypusine synthase by Khomutov, M. A., Simonian, A. R., Weisell, J., Vepsalainen, J., Kochetkov, S. N., Khomutov, A. R.

“…Earlier unknown hydroxylamine-containing analogues of 1-guanidino-7-aminohepane (GC7) containing the free aminooxy group (1-aminooxy-6-guanidinohexane),…”
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Leishmania donovani: structural insignt in the recognition of C-methylated analogues of spermidine as natural polyamine by Mandal, S, Khomutov, M A, Simonian, A P, Kochetkov, S N, Madhubala, R

“…The ability of alpha-, beta-, gamma- and omega-methylated spermidine analogues to restore the growth of L. donovani promastigotes that were depleted of…”
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Status of beryllium materials for fusion application by Khomutov, A.M., Davydov, D.A., Gorokhov, V.A., Kuprijanov, I.B., Mikhailov, V.S., Pakhomov, Ya.D.

“…The possible use of beryllium as a material for fusion reactors is discussed. Based on the results of recent Russian elaborations, which were not covered…”
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Methylated analogues of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism by Khomutov, A R, Keinanen, T A, Grigorenko, N A, Hyvonen, M T, Uimari, A, Pietila, M, Cerrada-Gimenez, M, Simonian, A R, Khomutov, M A, Verspalainen, J, Alhonen, L, Janne, J

“…Biogenic amines spermine and spermidine are essential factors of cellular growth. Polyamine analogues are widely used to investigate and to regulate the…”
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Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine by Khomutov, M. A., Hyvönen, M. T., Salikhov, A. I., Chizhov, A. O., Ryzhov, I. M., Kochetkov, S. N., Vepsäläinen, J., Keinänen, T. A., Khomutov, A. R.

“…A simple and practical 10-step synthesis is reported for previously unknown diastereomers of C ‑methylated spermine (Spm) analogue,…”
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Enantioselective synthesis of (R)- and (S)-3-methylspermidines by Khomutov, M. A., Keinanen, T. A., Hyvonen, M. T., Weisell, J., Vepsalainen, J., Alhonen, L., Kochetkov, S. N., Khomutov, A. R.

“…Earlier unknown enantiomerically pure ( R )- and ( S )-1,8-diamino-3-methyl-4-azaoctane’s (3-MeSpd’s) were synthesized within 11 steps with high overall yields…”
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Enantioselective Synthesis of (R)- and (S)-3-Methylspermidines by Khomutov, M A, Keinanen, T A, Hyvonen, M T, Weisell, J, Vepsalainen, J, Alhonen, L, Kochetkov, S N, Khomutov, A R

“…Earlier unknown enantiomerically pure (R)- and (S)-1,8-diamino-3-methyl-4-azaoctane's (3-MeSpd's) were synthesized with high overall yields and optical purity…”
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Novel metabolically stable and functionally active mimetic of spermidine by Khomutov, M. A., Hyvönen, M. T., Simonian, A. R., Vepsäläinen, J., Alhonen, L., Kochetkov, S. N., Keinänen, T. A.

“…Earlier unknown 1,8-diamino-3-methyl-4-azanonane (γ-MeSpd) was synthesized. The analogue was a substrate of neither spermine/spermidine N 1 -acetyltransferase…”
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