Search Results - "Khomutov, Alex R."

Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder–Robinson syndrome by Stewart, Tracy Murray, Foley, Jackson R, Holbert, Cassandra E, Khomutov, Maxim, Rastkari, Noushin, Tao, Xianzun, Khomutov, Alex R, Zhai, R Grace, Casero, Robert A

“…Snyder–Robinson syndrome (SRS) results from mutations in spermine synthase (SMS), which converts the polyamine spermidine into spermine. Affecting primarily…”
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Biogenic Polyamines and Related Metabolites by Ivanov, Alexander V, Khomutov, Alex R

“…The specific regulation of cell metabolism is one of cornerstones of biochemistry [...]…”
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Antibacterial Activity of Peptide Derivatives of Phosphinothricin against Multidrug-Resistant Klebsiella pneumoniae by Demiankova, Marija V, Giovannercole, Fabio, Khomutov, Maxim A, Salikhov, Arthur I, Onillon, Laura, Valuev-Elliston, Vladimir T, Vasilieva, Byazilya F, Khurs, Elena N, Gabrielyan, Nina I, Kochetkov, Sergey N, Efremenkova, Olga V, De Biase, Daniela, Khomutov, Alex R

“…The fast spread of bacteria that are resistant to many classes of antibiotics (multidrug resistant) is a global threat to human and animal health with a…”
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Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions by Hyvönen, Mervi T, Smirnova, Olga A, Mitkevich, Vladimir A, Tunitskaya, Vera L, Khomutov, Maxim, Karpov, Dmitry S, Korolev, Sergey P, Häkkinen, Merja R, Pietilä, Marko, Gottikh, Marina B, Vepsäläinen, Jouko, Alhonen, Leena, Makarov, Alexander A, Kochetkov, Sergey N, Wallace, Heather M, Keinänen, Tuomo A, Khomutov, Alex R

“…The polyamines, spermine (Spm) and spermidine (Spd), are important for cell growth and function. Their homeostasis is strictly controlled, and a key…”
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Inhibition of nicotinic acetylcholine receptors by oligoarginine peptides and polyamine-related compounds by Ojomoko, Lucy O, Kryukova, Elena V, Egorova, Natalya S, Salikhov, Arthur I, Epifanova, Lyubov A, Denisova, Daria A, Khomutov, Alex R, Sukhov, Dmitry A, Vassilevski, Alexander A, Khomutov, Maxim A, Tsetlin, Victor I, Shelukhina, Irina V

“…Oligoarginine peptides, known mostly for their cell-penetrating properties, are also inhibitors of the nicotinic acetylcholine receptors (nAChRs). Since…”
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Triethylenetetramine modulates polyamine and energy metabolism and inhibits cancer cell proliferation by Hyvönen, Mervi T, Ucal, Sebahat, Pasanen, Markku, Peräniemi, Sirpa, Weisell, Janne, Khomutov, Maxim, Khomutov, Alex R, Vepsäläinen, Jouko, Alhonen, Leena, Keinänen, Tuomo A

“…Polyamine metabolism is an attractive anticancer drug target, since polyamines are absolutely required for cellular proliferation, and increased levels of…”
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A Desmethylphosphinothricin Dipeptide Derivative Effectively Inhibits Escherichia coli and Bacillus subtilis Growth by Khomutov, Maxim A., Giovannercole, Fabio, Onillon, Laura, Demiankova, Marija V., Vasilieva, Byazilya F., Salikhov, Arthur I., Kochetkov, Sergey N., Efremenkova, Olga V., Khomutov, Alex R., De Biase, Daniela

“…New antibiotics are unquestionably needed to fight the emergence and spread of multidrug-resistant bacteria. To date, antibiotics targeting bacterial central…”
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Organophosphorus S -adenosyl- L -methionine mimetics: synthesis, stability, and substrate properties by Rudenko, Alexander Yu, Mariasina, Sofia S, Bolikhova, Anastasiia K, Nikulin, Maxim V, Ozhiganov, Ratislav M, Vasil'ev, Vasiliy G, Ikhalaynen, Yuri A, Khandazhinskaya, Anastasia L, Khomutov, Maxim A, Sergiev, Peter V, Khomutov, Alex R, Polshakov, Vladimir I

“…-Adenosyl-l-methionine (SAM)-mediated methylation of biomolecules controls their function and regulates numerous vital intracellular processes. Analogs of SAM…”
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Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase by Hyvönen, Mervi T, Keinänen, Tuomo A, Nuraeva, Gulgina K, Yanvarev, Dmitry V, Khomutov, Maxim, Khurs, Elena N, Kochetkov, Sergey N, Vepsäläinen, Jouko, Zhgun, Alexander A, Khomutov, Alex R

“…The biogenic polyamines, spermine, spermidine (Spd) and putrescine (Put) are present at micro-millimolar concentrations in eukaryotic and prokaryotic cells…”
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C -Methylated Spermidine Derivatives: Convenient Syntheses and Antizyme-Related Effects by Khomutov, Maxim A, Salikhov, Arthur I, Mitkevich, Vladimir A, Tunitskaya, Vera L, Smirnova, Olga A, Korolev, Sergey P, Chizhov, Alexander O, Gottikh, Marina B, Kochetkov, Sergey N, Khomutov, Alex R

“…The biogenic polyamines, spermidine (Spd) and spermine (Spm), are present at millimolar concentrations in all eukaryotic cells, where they participate in the…”
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Hepatitis C Virus Dysregulates Polyamine and Proline Metabolism and Perturbs the Urea Cycle by Zakirova, Natalia F, Khomich, Olga A, Smirnova, Olga A, Molle, Jennifer, Duponchel, Sarah, Yanvarev, Dmitry V, Valuev-Elliston, Vladimir T, Monnier, Lea, Grigorov, Boyan, Ivanova, Olga N, Karpenko, Inna L, Golikov, Mikhail V, Bovet, Cedric, Rindlisbacher, Barbara, Khomutov, Alex R, Kochetkov, Sergey N, Bartosch, Birke, Ivanov, Alexander V

“…Hepatitis C virus (HCV) is an oncogenic virus that causes chronic liver disease in more than 80% of patients. During the last decade, efficient direct-acting…”
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α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation by Hyvönen, Mervi T., Khomutov, Maxim, Vepsäläinen, Jouko, Khomutov, Alex R., Keinänen, Tuomo A.

“…Polyamine spermidine is essential for the proliferation of eukaryotic cells. Administration of polyamine biosynthesis inhibitor α-difluoromethylornithine…”
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Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators by Keinänen, Tuomo A, Grigorenko, Nikolay, Khomutov, Alex R, Huang, Qingqiu, Uimari, Anne, Alhonen, Leena, Hyvönen, Mervi T, Vepsäläinen, Jouko

“…Enzymes generally display strict stereospecificity and regioselectivity for their substrates. Here by using FAD-dependent human acetylpolyamine oxidase (APAO),…”
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Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A by Hyvönen, Mervi T, Koponen, Taina, Weisell, Janne, Pietilä, Marko, Khomutov, Alex R, Vepsäläinen, Jouko, Alhonen, Leena, Keinänen, Tuomo A

“…We have shown previously that the polyamine spermidine is indispensable for differentiation of 3T3-L1 preadipocytes. In the present study, we examined the…”
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A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane by Dufe, Veronica T, Ingner, Daniel, Heby, Olle, Khomutov, Alex R, Persson, Lo, Al-Karadaghi, Salam

“…The critical role of polyamines in key processes such as cell growth, differentiation and macromolecular synthesis makes the enzymes involved in their…”
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Charge deficient analogues of the natural polyamines by Weisell, Janne, Hyvönen, Mervi T, Alhonen, Leena, Vepsäläinen, Jouko, Keinänen, Tuomo A, Khomutov, Alex R

“…Mitochondrial dysfunction, either inherited or acquired, is associated with several diseases in humans. Depending on the cell type and location, cells are…”
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Spermidine is indispensable in differentiation of 3T3‐L1 fibroblasts to adipocytes by Vuohelainen, Susanna, Pirinen, Eija, Cerrada‐Gimenez, Marc, Keinänen, Tuomo A., Uimari, Anne, Pietilä, Marko, Khomutov, Alex R., Jänne, Juhani, Alhonen, Leena

“…Impaired adipogenesis has been shown to predispose to disturbed adipocyte function and development of metabolic abnormalities. Previous studies indicate that…”
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Role of Hypusinated Eukaryotic Translation Initiation Factor 5A in Polyamine Depletion-induced Cytostasis by Hyvönen, Mervi T., Keinänen, Tuomo A., Cerrada-Gimenez, Marc, Sinervirta, Riitta, Grigorenko, Nikolay, Khomutov, Alex R., Vepsäläinen, Jouko, Alhonen, Leena, Jänne, Juhani

“…We have earlier shown that α-methylated spermidine and spermine analogues rescue cells from polyamine depletion-induced growth inhibition and maintain…”
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3-Aminooxy-1-Aminopropane and Derivatives Have an Antiproliferative Effect on Cultured Plasmodium falciparum by Decreasing Intracellular Polyamine Concentrations by Das Gupta, Robin, Krause-Ihle, Tanja, Bergmann, Bärbel, Müller, Ingrid B, Khomutov, Alex R, Müller, Sylke, Walter, Rolf D, Lüersen, Kai

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Antileishmanial Effect of 3-Aminooxy-1-Aminopropane Is Due to Polyamine Depletion by Singh, Sushma, Mukherjee, Angana, Khomutov, Alex R, Persson, Lo, Heby, Olle, Chatterjee, Mitali, Madhubala, Rentala

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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