Search Results - "Khomutov, A. R."

Inhibition of DNA gyrase by levofloxacin and related fluorine-containing heterocyclic compounds by Tunitskaya, V L, Khomutov, A R, Kochetkov, S N, Kotovskaya, S K, Charushin, V N

“…Fluoroquinolones are an important class of modern and efficient antibacterial drugs with a broad spectrum of activity. Levofloxacin (the optically active form…”
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Synthesis of 2-Methylidene Spermidine and its N1-Acetylated Derivative by Khomutov, M. A., Khomutov, A. R.

“…— Simple and practical synthetic protocols have been developed for the preparation of earlier unknown 2-methylidene derivatives of spermidine and N 1…”
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Insights into the Functioning of the D-amino Acid Transaminase from Haliscomenobacter Hydrossis via a Structural and Spectral Analysis of its Complex with 3-Aminooxypropionic Acid by Bakunova, A K, Matyuta, I O, Nikolaeva, A Yu, Boyko, K M, Khomutov, A R, Bezsudnova, E Yu, Popov, V O

“…Pyridoxal 5'-phosphate-dependent enzymes play a crucial role in nitrogen metabolism. Carbonyl compounds, such as O-substituted hydroxylamines, stand out among…”
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Interaction of DNA Methyltransferase Dnmt3a with Phosphorus Analogs of S-Adenosylmethionine and S-Adenosylhomocysteine by Filonov, V. L., Khomutov, M. A., Sergeev, A. V., Khandazhinskaya, A. L., Kochetkov, S. N., Gromova, E. S., Khomutov, A. R.

“…Enzymatic methyltransferase reactions are of crucial importance for cell metabolism. S -Adenosyl- L -methionine (AdoMet) is a main donor of the methyl group…”
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C-Methylated Analogs of Spermine and Spermidine: Synthesis and Biological Activity by Khomutov, M. A., Mikhura, I. V., Kochetkov, S. N., Khomutov, A. R.

“…— Biogenic polyamines spermine and spermidine are present in eukaryotic cells in micro- and millimolar concentrations, that determines the multiplicity of…”
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Identification of a novel substrate-derived spermine oxidase inhibitor by Dunston, T. T., Khomutov, M. A., Gabelli, S. B., Stewart, T. M., Foley, J. R., Kochetkov, S. N., Khomutov, A. R., Casero Jr, R. A.

“…Homeostasis of the biogenic polyamines spermine (Spm) and spermidine (Spd), present in M-mM concentrations in all eukaryotic cells, is precisely regulated by…”
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Methylated analogs of spermine and spermidine as tools to investigate cellular functions of polyamines and enzymes of their metabolism by Khomutov, A. R, Keinanen, T. A, Grigorenko, N. A, Hyvonen, M. T, Uimari, A, Pietila, M, Cerrada-Gimenez, M, Simonian, A. R, Khomutov, M. A, Vepsalainen, J, Alhonen, L, Janne, J

“…Biogenic amines spermine (Spm) and spermidine (Spd) are essential for cell growth. Polyamine analogs are widely used to investigate the enzymes of polyamine…”
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Aminooxy adsorbents derived from sephareose and toyopearl by Khomutov, M. A., Solyev, P. N., Kochetkov, S. N., Khomutov, A. R.

“…Convenient synthetic schemes being suitable for the preparation of aminooxy-Sepharose and hydroxylamine-containing Toyopearl with capacity of 0.35–0.015 mmols…”
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Synthesis of 2,11-bis(methylidene)spermine, a new inhibitor of spermine oxidase by Grigorenko, N. A., Khomutov, M. A., Simonian, A. R., Kochetkov, S. N., Khomutov, A. R.

“…Earlier unknown 1,12-diamino-2,11-bis(methylidene)-4,9-diazadodecane, which may be considered as an enzyme-activated inhibitor of spermine oxidase, was…”
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Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus by Korovina, A. N., Tunitskaya, V. L., Khomutov, M. A., Simonian, A. R., Khomutov, A. R., Ivanov, A. V., Kochetkov, S. N.

“…Influence of the biogenic polyamines spermine, spermidine, and putrescine as well as their derivatives on the replication enzymes of hepatitis C virus (HCV)…”
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Novel hydroxylamine-containing analogues of 1-guanidino-7-aminoheptane (GC7), an effective inhibitor of deoxyhypusine synthase by Khomutov, M. A., Simonian, A. R., Weisell, J., Vepsalainen, J., Kochetkov, S. N., Khomutov, A. R.

“…Earlier unknown hydroxylamine-containing analogues of 1-guanidino-7-aminohepane (GC7) containing the free aminooxy group (1-aminooxy-6-guanidinohexane),…”
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Convenient syntheses of phosphinic analogues of γ-aminobutyric- and glutamic acids by Khomutov, M. A., Formanovsky, A. A., Mikhura, I. V., Vepsalainen, J., Kochetkov, S. N., De Biase, D., Khomutov, A. R.

“…Three-steps, one-pot synthesis of 2-amino-4-(hydroxyphosphinyl)butyric acid from dibutyl ester of vinylphosphinic acid was carried out with an overall yield of…”
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Hydroxylamine derivatives for regulation of spermine and spermidine metabolism by Khomutov, M. A., Weisell, J., Hyvönen, M., Keinänen, T. A., Vepsäläinen, J., Alhonen, L., Khomutov, A. R., Kochetkov, S. N.

“…The biogenic polyamines spermine, spermidine, and their precursor putrescine are present in micro-to-millimolar concentrations in all cell types and are…”
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Novel approach to design an isosteric charge-deficient analogue of spermine and its biochemically important derivatives by Khomutov, A R, Grigorenko, N A, Skuridin, S G

“…The design and synthesis of SpmTrien (1,12-diamino-3,6,9-triazadodecane), an isosteric and charge-deficient analogue of spermine with excellent chelating…”
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1-Aminooxy-3-aminopropane reversibly prevents the proliferation of cultured baby hamster kidney cells by interfering with polyamine synthesis by Hyvönen, T, Alakuijala, L, Andersson, L, Khomutov, A R, Khomutov, R M, Eloranta, T O

“…The effects on cultured baby hamster kidney cells of 1-aminooxy-3-aminopropane, a potent new inhibitor of mammalian ornithine and S-adenosylmethionine…”
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Acute Pancreatitis Induced by Activated Polyamine Catabolism Is Associated with Coagulopathy: Effects of α-Methylated Polyamine Analogs on Hemostasis by Hyvönen, M.T, Sinervirta, R, Keinänen, T.A, Fashe, T, Grigorenko, N, Khomutov, A.R, Vepsäläinen, J, Alhonen, L

“…Abstract Background/Aims: Polyamines are ubiquitous organic cations essential for cellular proliferation and tissue integrity. We have previously shown that…”
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Inhibition of agmatine transport in liver mitochondria by new charge-deficient agmatine analogues by Grillo, M A, Battaglia, V, Colombatto, S, Rossi, C A, Simonian, A R, Salvi, M, Khomutov, A R, Toninello, A

“…The charge of the agmatine analogues AO-Agm [N-(3-aminooxypropyl)guanidine], GAPA [N-(3-aminopropoxy)guanidine] and NGPG [N-(3-guanidinopropoxy)guanidine] is…”
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Cellular characterization of a new irreversible inhibitor of S-adenosylmethionine decarboxylase and its use in determining the relative abilities of individual polyamines to sustain growth and viability of L1210 cells by Kramer, D L, Khomutov, R M, Bukin, Y V, Khomutov, A R, Porter, C W

“…S-(5'-Deoxy-5'-adenosyl)methylthioethylhydroxylamine (AMA) is an irreversible inhibitor of S-adenosylmethionine (AdoMet) decarboxylase, which is designed to…”
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Aminooxy-analogues of spermidine: new partial agonists and antagonists at the polyamine site of the rat hippocampal NMDA receptor complex by Berger, Michael L., Khomutov, Alex R., Rebernik, Patrick

“…The amino-1-oxy- and amino-8-oxy-analogues of spermidine (1-O-SPD and 8-O-SPD) were tested in vitro with rat hippocampal membranes as potential modulators of…”
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Feedback regulation of S-adenosylmethionine decarboxylase synthesis by Persson, L, Khomutov, A R, Khomutov, R M

“…Treatment of Ehrlich ascites-tumour cells with 1-amino-oxy-3-aminopropane (AOAP), a potent inhibitor of ornithine decarboxylase, resulted in a marked decrease…”
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