Search Results - "Khokhar, A R"

Recruitment of trimeric proliferating cell nuclear antigen by G1-phase cyclin-dependent kinases following DNA damage with platinum-based antitumour agents by He, G, Kuang, J, Koomen, J, Kobayashi, R, Khokhar, A R, Siddik, Z H

“…Background: In cycling tumour cells, the binary cyclin-dependent kinase Cdk4/cyclin D or Cdk2/cyclin E complex is inhibited by p21 following DNA damage to…”
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Distinct Features of Vascular Diseases in COVID-19 by Ceasovschih, Alexandr, Sorodoc, Victorita, Shor, Annabelle, Haliga, Raluca Ecaterina, Roth, Lynn, Lionte, Catalina, Onofrei Aursulesei, Viviana, Sirbu, Oana, Culis, Nicolae, Shapieva, Albina, Tahir Khokhar, Mohammed A R, Statescu, Cristian, Sascau, Radu A, Coman, Adorata Elena, Stoica, Alexandra, Grigorescu, Elena-Daniela, Banach, Maciej, Thomopoulos, Costas, Sorodoc, Laurentiu

“…The Coronavirus Disease 2019 (COVID-19) pandemic was declared in early 2020 after several unexplained pneumonia cases were first reported in Wuhan, China, and…”
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Upregulation of p27 and its inhibition of CDK2 cyclin E activity following DNA damage by a novel platinum agent are dependent on the expression of p21 by He, G, Kuang, J, Huang, Z, Koomen, J, Kobayashi, R, Khokhar, A R, Siddik, Z H

“…The cisplatin analogue 1R,2R-diaminocyclohexane(trans-diacetato)(dichloro)platinum(IV) (DAP) is a DNA-damaging agent that will be entering clinical trials for…”
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Are Medical Students from Across the World Aware of Cervical Cancer, HPV Infection and Vaccination? A Cross-Sectional Comparative Study by Gismondi, M., Augustine, A. M., Tahir Khokhar, M. A. R., Khokhar, H. T., Twentyman, K. E., Florea, I. D., Grigore, M.

“…This study aims to understand and compare the level of knowledge, the attitude and the awareness of cervical cancer, HPV infection and vaccination among…”
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Phase I clinical and pharmacological study of intraperitoneal cis-bis-neodecanoato(trans-R, R-1, 2-diaminocyclohexane)-platinum II entrapped in multilamellar liposome vesicles by VERSCHRAEGEN, C. F, KUMAGAI, S, DAVIDSON, R, FEIG, B, MANSFIELD, P, LEE, S. J, MACLEAN, D. S, HU, W, KHOKHAR, A. R, SIDDIK, Z. H

“…To perform a phase I study of intraperitoneal cis-bis-neodecanoato ( trans- R, R-1, 2-diaminocyclohexane)-platinum II entrapped in multilamellar vesicles…”
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Expression of p53 in Cisplatin-resistant Ovarian Cancer Cell Lines: Modulation with the Novel Platinum Analogue (1R, 2R-Diaminocyclohexane)(trans-diacetato)(dichloro)-platinum(IV) by HAGOPIAN, G. S, MILLS, G. B, KHOKHAR, A. R, BAST, R. C, SIDDIK, Z. H

“…The compound ( 1R , 2R -diaminocyclohexane)( trans -diacetato)(dichloro)platinum(IV) (DACH-acetato-Pt) is a novel platinum-based antitumor agent with clinical…”
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Phase I clinical and pharmacological study of liposome-entrapped NDDP administered intrapleurally in patients with malignant pleural effusions by PEREZ-SOLER, R, SHIN, D. M, SIDDIK, Z. H, MURPHY, W. K, HUBER, M, JIN SOO LEE, KHOKHAR, A. R, HONG, W. K

“…cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum(II) (NDDP) is a lipophilic non-cross-resistant platinum compound formulated in large…”
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Intraliposomal chemical activation patterns of liposomal cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum (II) (L-NDDP)-a potential antitumour agent by MACLEAN, D. S, KHOKHAR, A. R, TYLE, P, PEREZ-SOLER, R

“…L-NDDP is a liposome-entrapped platinum compound currently in phase 2 clinical trials that has been shown to undergo intraliposomal activation. The…”
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Synthesis, characterization and cytotoxicity of new Platinum(IV) axial carboxylate complexes : Crystal structure of potential antitumor agent [PtIV(trans-1R, 2R-Diaminocyclohexane)trans(acetate)2Cl2] by ROUNAQ ALI KHAN, S, SHURONG HUANG, SHAMSUDDIN, S, INUTSUKA, S, WHITMIRE, K. H, SIDDIK, Z. H, KHOKHAR, A. R

“…A series of new platinum(IV) complexes of the type [PtIV(DACH)trans(L)2Cl2] (where DACH = trans-1R,2R-diaminocyclohexane, and L = acetate, propionate,…”
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Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities by GUANGAN HE, SIDDIK, Zahid H, ZAIFENG HUANG, RUONING WANG, KOOMEN, John, KOBAYASHI, Ryuji, KHOKHAR, Abdul R, JIAN KUANG

“…DNA damage often activates the p53-p21 pathway and causes G(1)-phase arrest in mammalian cells. Although there is ample evidence that p21 induction by p53…”
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Chemical and Biological Studies on a Series of Novel (trans-(1R,2R)-, trans-(1S,2S)-, and cis-1,2-Diaminocyclohexane)platinum(IV) Carboxylate Complexes by Khokhar, Abdul R, Al-Baker, Salam, Shamsuddin, Shaikh, Siddik, Zahid H

“…A series of novel platinum(IV) complexes of the type DACH-PtIV-trans-(Y)2-cis-X (where DACH = trans-(1R,2R)-, trans-(1S,2S)-, or cis-1,2-diaminocyclohexane; X…”
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Bimodal Effects of 1R,2R-Diaminocyclohexane(trans-diacetato)(dichloro)platinum(IV) on Cell Cycle Checkpoints by Kuang, J, He, G, Huang, Z, Khokhar, A R, Siddik, Z H

“…1R , 2R -Diaminocyclohexane( trans -diacetato)(dichloro)- platinum(IV) (DACH-acetato-Pt) is a novel platinum-based agent that is highly effective against…”
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Role of p53 in the ability of 1,2-diaminocyclohexane-diacetato-dichloro-Pt(IV) to circumvent cisplatin resistance by Siddik, Z.H, Hagopian, G.S, Thai, G, Tomisaki, S, Toyomasu, T, Khokhar, A.R

“…Several reports indicate that the mechanism of resistance to cisplatin is multifactorial. However, DNA damage tolerance appears to be the more significant…”
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Axial ligands and alicyclic ring size modulate the activity and biochemical pharmacology of ammine/cycloalkylamine-platinum(IV) complexes in tumor cells resistant to cis-diamminedichloroplatinum(II) or trans-1R,2R-1S,2S-diaminocyclohexanetetrachloroplatinum(IV) by YOSHIDA, M, KHOKHAR, A. R, SIDDIK, Z. H

“…A platinum(II) and 3 platinum(IV) ammine/cycloalkylamine homologous series were evaluated for cytotoxicity and biochemical pharmacology in murine leukemia…”
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Phase I clinical and pharmacological study of liposome-entrapped cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum(II) by PEREZ-SOLER, R, LOPEZ-BERESTEIN, G, LAUTERSZTAIN, J, AL-BAKER, S, FRANCIS, K, MACIAS-KIGER, D, RABER, M. N, KHOKHAR, A. R

“…cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum++ +(II) (NDDP) is a liposome dependent cisplatin analogue since the liposome carrier is required…”
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Preparation, characterization, and antitumor activity of new ethylenediamine platinum(IV) complexes containing mixed carboxylate ligands by Khokhar, A R, Deng, Y, Kido, Y, Siddik, Z H

“…A series of ethylenediamine platinum(IV) complexes of the type PtIV(en)XA2 and PtIV(en)X'2A2, where X = 1,1-cyclobutanedicarboxylato or malonato, X' = chloro,…”
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Pharmacokinetics of intravenously injected [3H]tetrachloro(D,L-trans)1,2-diaminocyclohexane platinum (IV) (tetraplatin) in mice by Kido, Y, Khokhar, A R, Siddik, Z H

“…Platinum (Pt) complexes with diaminocyclohexane (DACH) carrier ligand are of interest because of their effectiveness against tumor cells resistant to…”
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Haematological toxicity of carboplatin and cisplatin combined with whole body hyperthermia in rats by OHNO, S, STREBEL, F. R, STEPHENS, L. C, SIDDIK, Z. H, BABA, H, MAKINO, M, KHOKHAR, A. R, BULL, J. M. C

“…Acute haematological toxicity induced by cis-diammine-1,1-cyclobutane dicarboxylate platinum (II) (carboplatin) and cis-diamminedichloroplatinum (II)…”
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Pharmacokinetics of tetraplatin administered intraperitoneally with reduced glutathione in mice by Kido, Y, Khokhar, A R, Yoshida, M, Thai, G W, Siddik, Z H

“…Tetraplatin (Ormaplatin) has been developed as a second generation platinum complex because of its good antitumor activity against some cisplatin-resistant…”
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Lipophilic cisplatin analogues entrapped in liposomes : role to intraliposomal drug activation in biological activity by PEREZ-SOLER, R, KHOKHAR, A. R

“…cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum (II) (NDDP), a lipophilic cisplatin analogue containing two branched leaving groups of 10 carbon…”
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