Search Results - "Khodakhah, K"

Refine Results
  1. 1

    The role of interneurons in shaping Purkinje cell responses in the cerebellar cortex by Dizon, Maria Johanna, Khodakhah, Kamran

    Published in The Journal of neuroscience (20-07-2011)
    “…The well established anatomy of the cerebellar cortex has led to suggestions that cerebellar molecular layer interneurons laterally inhibit Purkinje cells. In…”
    Get full text
    Journal Article
  2. 2

    Developmental change in the contribution of voltage-gated Ca(2+) channels to the pacemaking of deep cerebellar nuclei neurons by Alviña, K, Tara, E, Khodakhah, K

    Published in Neuroscience (13-05-2016)
    “…The activity of the deep cerebellar nuclei (DCN) neurons conveys the bulk of the output of the cerebellum. To generate these motor signals, DCN neurons…”
    Get full text
    Journal Article
  3. 3

    Developmental change in the contribution of voltage-gated Ca2+ channels to the pacemaking of deep cerebellar nuclei neurons by Alviña, K, Tara, E, Khodakhah, K

    Published in Neuroscience (13-05-2016)
    “…Highlights • Voltage-gated Ca2+ channels (VGCCs) regulate cerebellar cell spontaneous activity. • We report a major age-related change in deep cerebellar cell…”
    Get full text
    Journal Article
  4. 4

    Large conductance calcium-activated potassium channels affect both spontaneous firing and intracellular calcium concentration in cerebellar Purkinje neurons by Womack, M.D, Hoang, C, Khodakhah, K

    Published in Neuroscience (15-09-2009)
    “…Abstract We investigated the contribution of large conductance calcium-activated potassium (BK) channels to spontaneous activity of cerebellar Purkinje neurons…”
    Get full text
    Journal Article
  5. 5

    T-type calcium channels mediate rebound firing in intact deep cerebellar neurons by Alviña, K, Ellis-Davies, G, Khodakhah, K

    Published in Neuroscience (23-01-2009)
    “…Abstract Neurons of the deep cerebellar nuclei (DCN) form the main output of the cerebellar circuitry and thus play an important role in cerebellar motor…”
    Get full text
    Journal Article
  6. 6

    Fast activation and inactivation of inositol trisphosphate-evoked Ca2+ release in rat cerebellar Purkinje neurones by Khodakhah, K, Ogden, D

    Published in The Journal of physiology (01-09-1995)
    “…1. Calcium release from stores via inositol trisphosphate (InsP3) activation of intracellular Ca2+ receptor-channels is thought to have a role in regulating…”
    Get full text
    Journal Article
  7. 7

    Inositol trisphosphate and ryanodine receptors share a common functional Ca2+ pool in cerebellar Purkinje neurons by Khodakhah, K., Armstrong, C.M.

    Published in Biophysical journal (01-12-1997)
    “…Changes in the intracellular free calcium concentration ([Ca2+]i) control many important processes in excitable and nonexcitable cells. In cerebellar Purkinje…”
    Get full text
    Journal Article
  8. 8

    Inositol 1,4,5-Triphosphate-Evoked Responses in Midbrain Dopamine Neurons by Morikawa, Hitoshi, Imani, Farzin, Khodakhah, Kamran, Williams, John T

    Published in The Journal of neuroscience (15-10-2000)
    “…Synaptically released glutamate evokes slow IPSPs mediated by metabotropic glutamate receptors (mGluRs) in midbrain dopamine neurons. These mGluR IPSPs are…”
    Get full text
    Journal Article
  9. 9

    Functional Heterogeneity of Calcium Release by Inositol Trisphosphate in Single Purkinje Neurones, Cultured Cerebellar Astrocytes, and Peripheral Tissues by Khodakhah, Kamran, Ogden, David

    “…Purkinje neurones of the cerebellar cortex are rich in receptors for the Ca-mobilizing second messenger inositol trisphosphate (InsP3) in association with…”
    Get full text
    Journal Article
  10. 10

    Cerebellar modulation of the reward circuitry and social behavior by Carta, Ilaria, Chen, Christopher H, Schott, Amanda L, Dorizan, Schnaude, Khodakhah, Kamran

    “…The cerebellum has been implicated in a number of nonmotor mental disorders such as autism spectrum disorder, schizophrenia, and addiction. However, its…”
    Get full text
    Journal Article
  11. 11

    Postsynaptic activation at the squid giant synapse by photolytic release of L-glutamate from a 'caged' L-glutamate by Corrie, J E, DeSantis, A, Katayama, Y, Khodakhah, K, Messenger, J B, Ogden, D C, Trentham, D R

    Published in The Journal of physiology (01-06-1993)
    “…1. Pharmacological evidence suggests L-glutamate is a strong candidate as a transmitter at the giant synapse of the squid. Postsynaptic activation at the giant…”
    Get full text
    Journal Article
  12. 12
  13. 13

    Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia by Khodakhah, Kamran, Walter, Joy T, Alviña, Karina, Womack, Mary D, Chevez, Carolyn

    Published in Nature neuroscience (01-03-2006)
    “…Episodic ataxia type-2 (EA2) is caused by mutations in P/Q-type voltage-gated calcium channels that are expressed at high densities in cerebellar Purkinje…”
    Get full text
    Journal Article
  14. 14

    Active Contribution of Dendrites to the Tonic and Trimodal Patterns of Activity in Cerebellar Purkinje Neurons by Womack, Mary, Khodakhah, Kamran

    Published in The Journal of neuroscience (15-12-2002)
    “…The cerebellum is responsible for coordination of movement and maintenance of balance. Cerebellar architecture is based on repeats of an anatomically well…”
    Get full text
    Journal Article
  15. 15

    Calcium-Activated Potassium Channels Are Selectively Coupled to P/Q-Type Calcium Channels in Cerebellar Purkinje Neurons by Womack, Mary D, Chevez, Carolyn, Khodakhah, Kamran

    Published in The Journal of neuroscience (06-10-2004)
    “…Cerebellar Purkinje neurons fire spontaneously in the absence of synaptic transmission. P/Q-type voltage-gated calcium channels and calcium-activated potassium…”
    Get full text
    Journal Article
  16. 16

    Somatic and Dendritic Small-Conductance Calcium-Activated Potassium Channels Regulate the Output of Cerebellar Purkinje Neurons by Womack, Mary D, Khodakhah, Kamran

    Published in The Journal of neuroscience (01-04-2003)
    “…Cerebellar Purkinje neurons provide the sole output of the cerebellar cortex and play a crucial role in motor coordination and maintenance of balance. They are…”
    Get full text
    Journal Article
  17. 17

    Selective regulation of spontaneous activity of neurons of the deep cerebellar nuclei by N-type calcium channels in juvenile rats by Alviña, Karina, Khodakhah, Kamran

    Published in The Journal of physiology (15-05-2008)
    “…The cerebellum coordinates movement and maintains body posture. The main output of the cerebellum is formed by three deep nuclei, which receive direct…”
    Get full text
    Journal Article
  18. 18

    Dendritic Control of Spontaneous Bursting in Cerebellar Purkinje Cells by Womack, Mary D, Khodakhah, Kamran

    Published in The Journal of neuroscience (07-04-2004)
    “…We investigated the mechanisms that contribute to spontaneous regular bursting in adult Purkinje neurons in acutely prepared cerebellar slices. Bursts…”
    Get full text
    Journal Article
  19. 19

    The Functional Equivalence of Ascending and Parallel Fiber Inputs in Cerebellar Computation by Walter, Joy T, Dizon, Maria-Johanna, Khodakhah, Kamran

    Published in The Journal of neuroscience (01-07-2009)
    “…At the center of the computational cerebellar circuitry are Purkinje cells, which integrate synaptic inputs from >150,000 granule cell inputs. Traditional…”
    Get full text
    Journal Article
  20. 20

    Two Intracellular Pathways Mediate Metabotropic Glutamate Receptor-Induced Ca2+ Mobilization in Dopamine Neurons by Morikawa, Hitoshi, Khodakhah, Kamran, Williams, John T

    Published in The Journal of neuroscience (01-01-2003)
    “…Activation of metabotropic glutamate receptors (mGluRs) causes membrane hyperpolarization in midbrain dopamine neurons. This hyperpolarization results from the…”
    Get full text
    Journal Article