Search Results - "Khodakhah, K"
-
1
The role of interneurons in shaping Purkinje cell responses in the cerebellar cortex
Published in The Journal of neuroscience (20-07-2011)“…The well established anatomy of the cerebellar cortex has led to suggestions that cerebellar molecular layer interneurons laterally inhibit Purkinje cells. In…”
Get full text
Journal Article -
2
Developmental change in the contribution of voltage-gated Ca(2+) channels to the pacemaking of deep cerebellar nuclei neurons
Published in Neuroscience (13-05-2016)“…The activity of the deep cerebellar nuclei (DCN) neurons conveys the bulk of the output of the cerebellum. To generate these motor signals, DCN neurons…”
Get full text
Journal Article -
3
Developmental change in the contribution of voltage-gated Ca2+ channels to the pacemaking of deep cerebellar nuclei neurons
Published in Neuroscience (13-05-2016)“…Highlights • Voltage-gated Ca2+ channels (VGCCs) regulate cerebellar cell spontaneous activity. • We report a major age-related change in deep cerebellar cell…”
Get full text
Journal Article -
4
Large conductance calcium-activated potassium channels affect both spontaneous firing and intracellular calcium concentration in cerebellar Purkinje neurons
Published in Neuroscience (15-09-2009)“…Abstract We investigated the contribution of large conductance calcium-activated potassium (BK) channels to spontaneous activity of cerebellar Purkinje neurons…”
Get full text
Journal Article -
5
T-type calcium channels mediate rebound firing in intact deep cerebellar neurons
Published in Neuroscience (23-01-2009)“…Abstract Neurons of the deep cerebellar nuclei (DCN) form the main output of the cerebellar circuitry and thus play an important role in cerebellar motor…”
Get full text
Journal Article -
6
Fast activation and inactivation of inositol trisphosphate-evoked Ca2+ release in rat cerebellar Purkinje neurones
Published in The Journal of physiology (01-09-1995)“…1. Calcium release from stores via inositol trisphosphate (InsP3) activation of intracellular Ca2+ receptor-channels is thought to have a role in regulating…”
Get full text
Journal Article -
7
Inositol trisphosphate and ryanodine receptors share a common functional Ca2+ pool in cerebellar Purkinje neurons
Published in Biophysical journal (01-12-1997)“…Changes in the intracellular free calcium concentration ([Ca2+]i) control many important processes in excitable and nonexcitable cells. In cerebellar Purkinje…”
Get full text
Journal Article -
8
Inositol 1,4,5-Triphosphate-Evoked Responses in Midbrain Dopamine Neurons
Published in The Journal of neuroscience (15-10-2000)“…Synaptically released glutamate evokes slow IPSPs mediated by metabotropic glutamate receptors (mGluRs) in midbrain dopamine neurons. These mGluR IPSPs are…”
Get full text
Journal Article -
9
Functional Heterogeneity of Calcium Release by Inositol Trisphosphate in Single Purkinje Neurones, Cultured Cerebellar Astrocytes, and Peripheral Tissues
Published in Proceedings of the National Academy of Sciences - PNAS (01-06-1993)“…Purkinje neurones of the cerebellar cortex are rich in receptors for the Ca-mobilizing second messenger inositol trisphosphate (InsP3) in association with…”
Get full text
Journal Article -
10
Cerebellar modulation of the reward circuitry and social behavior
Published in Science (American Association for the Advancement of Science) (18-01-2019)“…The cerebellum has been implicated in a number of nonmotor mental disorders such as autism spectrum disorder, schizophrenia, and addiction. However, its…”
Get full text
Journal Article -
11
Postsynaptic activation at the squid giant synapse by photolytic release of L-glutamate from a 'caged' L-glutamate
Published in The Journal of physiology (01-06-1993)“…1. Pharmacological evidence suggests L-glutamate is a strong candidate as a transmitter at the giant synapse of the squid. Postsynaptic activation at the giant…”
Get full text
Journal Article -
12
Cerebellar Pathophysiology in a Mouse Model of Spinocerebellar Ataxia
Published in Frontiers in cellular neuroscience (2010)“…Abstract only…”
Get full text
Journal Article -
13
Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia
Published in Nature neuroscience (01-03-2006)“…Episodic ataxia type-2 (EA2) is caused by mutations in P/Q-type voltage-gated calcium channels that are expressed at high densities in cerebellar Purkinje…”
Get full text
Journal Article -
14
Active Contribution of Dendrites to the Tonic and Trimodal Patterns of Activity in Cerebellar Purkinje Neurons
Published in The Journal of neuroscience (15-12-2002)“…The cerebellum is responsible for coordination of movement and maintenance of balance. Cerebellar architecture is based on repeats of an anatomically well…”
Get full text
Journal Article -
15
Calcium-Activated Potassium Channels Are Selectively Coupled to P/Q-Type Calcium Channels in Cerebellar Purkinje Neurons
Published in The Journal of neuroscience (06-10-2004)“…Cerebellar Purkinje neurons fire spontaneously in the absence of synaptic transmission. P/Q-type voltage-gated calcium channels and calcium-activated potassium…”
Get full text
Journal Article -
16
Somatic and Dendritic Small-Conductance Calcium-Activated Potassium Channels Regulate the Output of Cerebellar Purkinje Neurons
Published in The Journal of neuroscience (01-04-2003)“…Cerebellar Purkinje neurons provide the sole output of the cerebellar cortex and play a crucial role in motor coordination and maintenance of balance. They are…”
Get full text
Journal Article -
17
Selective regulation of spontaneous activity of neurons of the deep cerebellar nuclei by N-type calcium channels in juvenile rats
Published in The Journal of physiology (15-05-2008)“…The cerebellum coordinates movement and maintains body posture. The main output of the cerebellum is formed by three deep nuclei, which receive direct…”
Get full text
Journal Article -
18
Dendritic Control of Spontaneous Bursting in Cerebellar Purkinje Cells
Published in The Journal of neuroscience (07-04-2004)“…We investigated the mechanisms that contribute to spontaneous regular bursting in adult Purkinje neurons in acutely prepared cerebellar slices. Bursts…”
Get full text
Journal Article -
19
The Functional Equivalence of Ascending and Parallel Fiber Inputs in Cerebellar Computation
Published in The Journal of neuroscience (01-07-2009)“…At the center of the computational cerebellar circuitry are Purkinje cells, which integrate synaptic inputs from >150,000 granule cell inputs. Traditional…”
Get full text
Journal Article -
20
Two Intracellular Pathways Mediate Metabotropic Glutamate Receptor-Induced Ca2+ Mobilization in Dopamine Neurons
Published in The Journal of neuroscience (01-01-2003)“…Activation of metabotropic glutamate receptors (mGluRs) causes membrane hyperpolarization in midbrain dopamine neurons. This hyperpolarization results from the…”
Get full text
Journal Article