Search Results - "Khochbin, Saadi"

The growing landscape of tubulin acetylation: lysine 40 and many more by Sadoul, Karin, Khochbin, Saadi

“…Tubulin heterodimers are the building block of microtubules, which are major elements of the cytoskeleton. Several types of post-translational modifications…”
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Transcription factor dimerization activates the p300 acetyltransferase by Ortega, Esther, Rengachari, Srinivasan, Ibrahim, Ziad, Hoghoughi, Naghmeh, Gaucher, Jonathan, Holehouse, Alex S., Khochbin, Saadi, Panne, Daniel

“…The transcriptional co-activator p300 is a histone acetyltransferase (HAT) that is typically recruited to transcriptional enhancers and regulates gene…”
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Nucleoside Diphosphate Kinases Are ATP-Regulated Carriers of Short-Chain Acyl-CoAs by Iuso, Domenico, Guilliaumet, Julie, Schlattner, Uwe, Khochbin, Saadi

“…Nucleoside diphosphate (NDP) kinases 1 and 2 (NME1/2) are well-characterized enzymes known for their NDP kinase activity. Recently, these enzymes have been…”
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Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification by Tan, Minjia, Luo, Hao, Lee, Sangkyu, Jin, Fulai, Yang, Jeong Soo, Montellier, Emilie, Buchou, Thierry, Cheng, Zhongyi, Rousseaux, Sophie, Rajagopal, Nisha, Lu, Zhike, Ye, Zhen, Zhu, Qin, Wysocka, Joanna, Ye, Yang, Khochbin, Saadi, Ren, Bing, Zhao, Yingming

“…We report the identification of 67 previously undescribed histone modifications, increasing the current number of known histone marks by about 70%. We further…”
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NUT Is a Driver of p300-Mediated Histone Hyperacetylation: From Spermatogenesis to Cancer by Rousseaux, Sophie, Reynoird, Nicolas, Khochbin, Saadi

“…In maturing sperm cells, a major genome re-organization takes place, which includes a global increase in the acetylation of histones prior to their replacement…”
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The combined detection of Amphiregulin, Cyclin A1 and DDX20/Gemin3 expression predicts aggressive forms of oral squamous cell carcinoma by Bourova-Flin, Ekaterina, Derakhshan, Samira, Goudarzi, Afsaneh, Wang, Tao, Vitte, Anne-Laure, Chuffart, Florent, Khochbin, Saadi, Rousseaux, Sophie, Aminishakib, Pouyan

“…Background Large-scale genetic and epigenetic deregulations enable cancer cells to ectopically activate tissue-specific expression programmes. A specifically…”
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Histone crotonylation specifically marks the haploid male germ cell gene expression program by Montellier, Emilie, Rousseaux, Sophie, Zhao, Yingming, Khochbin, Saadi

“…The haploid male germ cell differentiation program controls essential steps of male gametogenesis and relies partly on a significant number of sex…”
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Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters by Goudarzi, Afsaneh, Zhang, Di, Huang, He, Barral, Sophie, Kwon, Oh Kwang, Qi, Shankang, Tang, Zhanyun, Buchou, Thierry, Vitte, Anne-Laure, He, Tieming, Cheng, Zhongyi, Montellier, Emilie, Gaucher, Jonathan, Curtet, Sandrine, Debernardi, Alexandra, Charbonnier, Guillaume, Puthier, Denis, Petosa, Carlo, Panne, Daniel, Rousseaux, Sophie, Roeder, Robert G., Zhao, Yingming, Khochbin, Saadi

“…Recently discovered histone lysine acylation marks increase the functional diversity of nucleosomes well beyond acetylation. Here, we focus on histone…”
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Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6 by Zilberman, Yuliya, Ballestrem, Christoph, Carramusa, Letizia, Mazitschek, Ralph, Khochbin, Saadi, Bershadsky, Alexander

“…We studied the role of a class II histone deacetylase, HDAC6, known to function as a potent α-tubulin deacetylase, in the regulation of microtubule dynamics…”
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Histone Acylation beyond Acetylation: Terra Incognita in Chromatin Biology by Rousseaux, Sophie, Khochbin, Saadi

“…Histone acetylation, one of the first and best studied histone post-translational modifications (PTMs), as well as the factors involved in its deposition…”
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Response to letter-to-the-editor: “Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA” by Schlattner, Uwe, Khochbin, Saadi, Petosa, Carlo

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The Tale of Protein Lysine Acetylation in the Cytoplasm by Sadoul, Karin, Wang, Jin, Diagouraga, Boubou, Khochbin, Saadi

“…Reversible posttranslational modification of internal lysines in many cellular or viral proteins is now emerging as part of critical signalling processes…”
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A bromodomain–DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT by Miller, Thomas C. R., Simon, Bernd, Rybin, Vladimir, Grötsch, Helga, Curtet, Sandrine, Khochbin, Saadi, Carlomagno, Teresa, Müller, Christoph W.

“…Bromodomains are critical components of many chromatin modifying/remodelling proteins and are emerging therapeutic targets, yet how they interact with…”
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Regulation of protein turnover by acetyltransferases and deacetylases by Sadoul, Karin, Boyault, Cyril, Pabion, Michel, Khochbin, Saadi

“…Lysine acetylation was first discovered as a post-translational modification of histones and has long been considered as a direct regulator of chromatin…”
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Structural insights into p300 regulation and acetylation-dependent genome organisation by Ibrahim, Ziad, Wang, Tao, Destaing, Olivier, Salvi, Nicola, Hoghoughi, Naghmeh, Chabert, Clovis, Rusu, Alexandra, Gao, Jinjun, Feletto, Leonardo, Reynoird, Nicolas, Schalch, Thomas, Zhao, Yingming, Blackledge, Martin, Khochbin, Saadi, Panne, Daniel

“…Histone modifications are deposited by chromatin modifying enzymes and read out by proteins that recognize the modified state. BRD4-NUT is an oncogenic fusion…”
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Motor-driven marginal band coiling promotes cell shape change during platelet activation by Diagouraga, Boubou, Grichine, Alexei, Fertin, Arnold, Wang, Jin, Khochbin, Saadi, Sadoul, Karin

“…Platelets float in the blood as discoid particles. Their shape is maintained by microtubules organized in a ring structure, the so-called marginal band (MB),…”
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Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers by Rousseaux, Sophie, Debernardi, Alexandra, Jacquiau, Baptiste, Vitte, Anne-Laure, Vesin, Aurélien, Nagy-Mignotte, Hélène, Moro-Sibilot, Denis, Brichon, Pierre-Yves, Lantuejoul, Sylvie, Hainaut, Pierre, Laffaire, Julien, de Reyniès, Aurélien, Beer, David G, Timsit, Jean-François, Brambilla, Christian, Brambilla, Elisabeth, Khochbin, Saadi

“…Activation of normally silent tissue-specific genes and the resulting cell "identity crisis" are the unexplored consequences of malignant epigenetic…”
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From meiosis to postmeiotic events: The secrets of histone disappearance by Gaucher, Jonathan, Reynoird, Nicolas, Montellier, Emilie, Boussouar, Fayçal, Rousseaux, Sophie, Khochbin, Saadi

“…One of the most obscure phenomena in modern biology is the near genome-wide displacement of histones that occurs during the postmeiotic phases of…”
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Aberrant activation of five embryonic stem cell-specific genes robustly predicts a high risk of relapse in breast cancers by Jacquet, Emmanuelle, Chuffart, Florent, Vitte, Anne-Laure, Nika, Eleni, Mousseau, Mireille, Khochbin, Saadi, Rousseaux, Sophie, Bourova-Flin, Ekaterina

“…Abstract Background In breast cancer, as in all cancers, genetic and epigenetic deregulations can result in out-of-context expressions of a set of normally…”
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Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally by Zhang, Yu, Kwon, SoHee, Yamaguchi, Teppei, Cubizolles, Fabien, Rousseaux, Sophie, Kneissel, Michaela, Cao, Chun, Li, Na, Cheng, Hwei-Ling, Chua, Katrin, Lombard, David, Mizeracki, Adam, Matthias, Gabriele, Alt, Frederick W., Khochbin, Saadi, Matthias, Patrick

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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