Search Results - "Kherdjemil, Yacine"
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HOX13-dependent chromatin accessibility underlies the transition towards the digit development program
Published in Nature communications (19-05-2020)“…Hox genes encode transcription factors (TFs) that establish morphological diversity in the developing embryo. The similar DNA-binding motifs of the various HOX…”
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A Hoxa13:Cre mouse strain for conditional gene manipulation in developing limb, hindgut, and urogenital system
Published in Genesis (New York, N.Y. : 2000) (01-06-2015)“…SUMMARY The developing limb is a useful model for studying organogenesis and developmental processes. Although Cre alleles exist for conditional loss‐ or…”
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Evolution of Hoxa11 regulation in vertebrates is linked to the pentadactyl state
Published in Nature (London) (03-11-2016)“…The mutually exclusive expression of the Hoxa11 and Hoxa13 genes is required for pentadactyl (five-digit) limbs and is proposed to have contributed to the…”
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Downregulation of Grem1 expression in the distal limb mesoderm is a necessary precondition for phalanx development
Published in Developmental dynamics (01-09-2022)“…Background The phalanges are the final skeletal elements to form in the vertebrate limb and their identity is regulated by signaling at the phalanx forming…”
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Insights on the role of hox genes in the emergence of the pentadactyl ground state
Published in Genesis (New York, N.Y. : 2000) (01-01-2018)“…Tetrapods are characterized by the presence of digits at the distal end of their limbs, which have emerged during the transition from fins to limbs. While…”
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Paracrine FGF1 signaling directs pituitary architecture and size
Published in Proceedings of the National Academy of Sciences - PNAS (01-10-2024)“…Organ architecture is established during development through intricate cell-cell communication mechanisms, yet the specific signals mediating these…”
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Extremely rapid and reversible optogenetic perturbation of nuclear proteins in living embryos
Published in Developmental cell (23-08-2021)“…Many developmental regulators have complex and context-specific roles in different tissues and stages, making the dissection of their function extremely…”
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Mapping the global interactome of the ARF family reveals spatial organization in cellular signaling pathways
Published in Journal of cell science (01-05-2024)“…The ADP-ribosylation factors (ARFs) and ARF-like (ARL) GTPases serve as essential molecular switches governing a wide array of cellular processes. In this…”
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A H oxa13 :Cre mouse strain for conditional gene manipulation in developing limb, hindgut, and urogenital system
Published in Genesis (New York, N.Y. : 2000) (01-06-2015)“…SUMMARY The developing limb is a useful model for studying organogenesis and developmental processes. Although Cre alleles exist for conditional loss‐ or…”
Get full text
Journal Article