Search Results - "Khelashvili, George"

How cholesterol stiffens unsaturated lipid membranes by Chakraborty, Saptarshi, Doktorova, Milka, Molugu, Trivikram R., Heberle, Frederick A., Scott, Haden L., Dzikovski, Boris, Nagao, Michihiro, Stingaciu, Laura-Roxana, Standaert, Robert F., Barrera, Francisco N., Katsaras, John, Khelashvili, George, Brown, Michael F., Ashkar, Rana

“…Cholesterol is an integral component of eukaryotic cell membranes and a key molecule in controlling membrane fluidity, organization, and other physicochemical…”
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A New Computational Method for Membrane Compressibility: Bilayer Mechanical Thickness Revisited by Doktorova, Milka, LeVine, Michael V., Khelashvili, George, Weinstein, Harel

“…Because lipid bilayers can bend and stretch in ways similar to thin elastic sheets, physical models of bilayer deformation have utilized mechanical constants…”
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Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase by Lee, Byoung-Cheol, Khelashvili, George, Falzone, Maria, Menon, Anant K., Weinstein, Harel, Accardi, Alessio

“…Members of the TMEM16/ANO family of membrane proteins are Ca 2+ -activated phospholipid scramblases and/or Cl − channels. A membrane-exposed hydrophilic groove…”
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Substrate binding-induced conformational transitions in the omega-3 fatty acid transporter MFSD2A by Bergman, Shana, Cater, Rosemary J., Plante, Ambrose, Mancia, Filippo, Khelashvili, George

“…Major Facilitator Superfamily Domain containing 2 A (MFSD2A) is a transporter that is highly enriched at the blood-brain and blood-retinal barriers, where it…”
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A Machine Learning Approach for the Discovery of Ligand-Specific Functional Mechanisms of GPCRs by Plante, Ambrose, Shore, Derek M, Morra, Giulia, Khelashvili, George, Weinstein, Harel

“…G protein-coupled receptors (GPCRs) play a key role in many cellular signaling mechanisms, and must select among multiple coupling possibilities in a…”
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GPCRmd uncovers the dynamics of the 3D-GPCRome by Rodríguez-Espigares, Ismael, Torrens-Fontanals, Mariona, Tiemann, Johanna K. S., Aranda-García, David, Ramírez-Anguita, Juan Manuel, Stepniewski, Tomasz Maciej, Worp, Nathalie, Varela-Rial, Alejandro, Morales-Pastor, Adrián, Medel-Lacruz, Brian, Pándy-Szekeres, Gáspár, Mayol, Eduardo, Giorgino, Toni, Carlsson, Jens, Deupi, Xavier, Filipek, Slawomir, Filizola, Marta, Gómez-Tamayo, José Carlos, Gonzalez, Angel, Gutiérrez-de-Terán, Hugo, Jiménez-Rosés, Mireia, Jespers, Willem, Kapla, Jon, Khelashvili, George, Kolb, Peter, Latek, Dorota, Marti-Solano, Maria, Matricon, Pierre, Matsoukas, Minos-Timotheos, Miszta, Przemyslaw, Olivella, Mireia, Perez-Benito, Laura, Provasi, Davide, Ríos, Santiago, R. Torrecillas, Iván, Sallander, Jessica, Sztyler, Agnieszka, Vasile, Silvana, Weinstein, Harel, Zachariae, Ulrich, Hildebrand, Peter W., De Fabritiis, Gianni, Sanz, Ferran, Gloriam, David E., Cordomi, Arnau, Guixà-González, Ramon, Selent, Jana

“…G-protein-coupled receptors (GPCRs) are involved in numerous physiological processes and are the most frequent targets of approved drugs. The explosion in the…”
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Allosteric Mechanisms of Molecular Machines at the Membrane: Transport by Sodium-Coupled Symporters by LeVine, Michael V, Cuendet, Michel A, Khelashvili, George, Weinstein, Harel

“…Solute transport across cell membranes is ubiquitous in biology as an essential physiological process. Secondary active transporters couple the unfavorable…”
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How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties by Razavi, Asghar M, Khelashvili, George, Weinstein, Harel

“…Much of the structure-based mechanistic understandings of the function of SLC6A neurotransmitter transporters emerged from the study of their bacterial…”
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Mechanisms of Lipid Scrambling by the G Protein-Coupled Receptor Opsin by Morra, Giulia, Razavi, Asghar M., Pandey, Kalpana, Weinstein, Harel, Menon, Anant K., Khelashvili, George

“…Several class-A G protein-coupled receptor (GPCR) proteins act as constitutive phospholipid scramblases catalyzing the transbilayer translocation of >10,000…”
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Transport domain unlocking sets the uptake rate of an aspartate transporter by Akyuz, Nurunisa, Georgieva, Elka R., Zhou, Zhou, Stolzenberg, Sebastian, Cuendet, Michel A., Khelashvili, George, Altman, Roger B., Terry, Daniel S., Freed, Jack H., Weinstein, Harel, Boudker, Olga, Blanchard, Scott C.

“…Glutamate transporters terminate neurotransmission by clearing synaptically released glutamate from the extracellular space, allowing repeated rounds of…”
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Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16 by Khelashvili, George, Falzone, Maria E., Cheng, Xiaolu, Lee, Byoung-Cheol, Accardi, Alessio, Weinstein, Harel

“…Both lipid and ion translocation by Ca 2+ -regulated TMEM16 transmembrane proteins utilizes a membrane-exposed hydrophilic groove. Several conformations of the…”
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Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins by Khelashvili, George, Cheng, Xiaolu, Falzone, Maria E., Doktorova, Milka, Accardi, Alessio, Weinstein, Harel

“…Recent discoveries about functional mechanisms of proteins in the TMEM16 family of phospholipid scramblases have illuminated the dual role of the membrane as…”
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X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release by Gotfryd, Kamil, Boesen, Thomas, Mortensen, Jonas S., Khelashvili, George, Quick, Matthias, Terry, Daniel S., Missel, Julie W., LeVine, Michael V., Gourdon, Pontus, Blanchard, Scott C., Javitch, Jonathan A., Weinstein, Harel, Loland, Claus J., Nissen, Poul, Gether, Ulrik

“…Neurotransmitter:sodium symporters (NSS) are conserved from bacteria to man and serve as targets for drugs, including antidepressants and psychostimulants…”
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A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport by Terry, Daniel S., Kolster, Rachel A., Quick, Matthias, LeVine, Michael V., Khelashvili, George, Zhou, Zhou, Weinstein, Harel, Javitch, Jonathan A., Blanchard, Scott C.

“…Neurotransmitter:sodium symporters (NSS), targets of antidepressants and psychostimulants, clear neurotransmitters from the synaptic cleft through sodium (Na +…”
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The permeation of potassium ions through the lipid scrambling path of the membrane protein nhTMEM16 by Cheng, Xiaolu, Khelashvili, George, Weinstein, Harel

“…The TMEM16 family of transmembrane proteins includes Ca -activated phospholipid scramblases (PLS) that can also function as non-selective ion channels…”
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Ligand modulation of sidechain dynamics in a wild-type human GPCR by Clark, Lindsay D, Dikiy, Igor, Chapman, Karen, Rödström, Karin Ej, Aramini, James, LeVine, Michael V, Khelashvili, George, Rasmussen, Søren Gf, Gardner, Kevin H, Rosenbaum, Daniel M

“…GPCRs regulate all aspects of human physiology, and biophysical studies have deepened our understanding of GPCR conformational regulation by different ligands…”
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Exchange of water for sterol underlies sterol egress from a StARkin domain by Khelashvili, George, Chauhan, Neha, Pandey, Kalpana, Eliezer, David, Menon, Anant K

“…Previously we identified Lam/GramD1 proteins, a family of endoplasmic reticulum membrane proteins with sterol-binding StARkin domains that are implicated in…”
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The allosteric mechanism leading to an open-groove lipid conductive state of the TMEM16F scramblase by Khelashvili, George, Kots, Ekaterina, Cheng, Xiaolu, Levine, Michael V., Weinstein, Harel

“…TMEM16F is a Ca 2+ -activated phospholipid scramblase in the TMEM16 family of membrane proteins. Unlike other TMEM16s exhibiting a membrane-exposed hydrophilic…”
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Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin by Khelashvili, George, Pillai, Anoop Narayana, Lee, Joon, Pandey, Kalpana, Payne, Alexander M., Siegel, Zarek, Cuendet, Michel A., Lewis, Tylor R., Arshavsky, Vadim Y., Broichhagen, Johannes, Levitz, Joshua, Menon, Anant K.

“…Mutations in the G protein-coupled receptor (GPCR) rhodopsin are a common cause of autosomal dominant retinitis pigmentosa, a blinding disease. Rhodopsin…”
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Light-independent phospholipid scramblase activity of bacteriorhodopsin from Halobacterium salinarum by Verchère, Alice, Ou, Wei-Lin, Ploier, Birgit, Morizumi, Takefumi, Goren, Michael A., Bütikofer, Peter, Ernst, Oliver P., Khelashvili, George, Menon, Anant K.

“…The retinylidene protein bacteriorhodopsin (BR) is a heptahelical light-dependent proton pump found in the purple membrane of the archaeon Halobacterium…”
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