Search Results - "Khdour, Omar M."

Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting by Chevalier, Arnaud, Zhang, Yanmin, Khdour, Omar M, Kaye, Justin B, Hecht, Sidney M

“…Nitroreductase (NTR) activities have been known for decades, studied extensively in bacteria and also in systems as diverse as yeast, trypanosomes, and hypoxic…”
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Selective Functionalization of Antimycin A Through an N‑Transacylation Reaction by Chevalier, Arnaud, Zhang, Yanmin, Khdour, Omar M, Hecht, Sidney M

“…Acylation of 3-(N-formylamino)­salicylic acids resulted in transacylation with loss of the formyl moiety. The reaction proceeds through a bis-N-acylated…”
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Novel idebenone analogs block Shc’s access to insulin receptor to improve insulin sensitivity by Hui, ChunKiu, Tomilov, Alexey, Garcia, Chase, Jiang, XiaoSong, Fash, David M., Khdour, Omar M., Rosso, Cristian, Filippini, Giacomo, Prato, Maurizio, Graham, James, Hecht, Sidney, Havel, Peter, Cortopassi, Gino

“…[Display omitted] •Idebenone drug engagement of p52Shc protein regulates insulin sensitivity.•Analogs of idebenone engage p52Shc and insulin-sensitizer…”
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Optimization of pyrimidinol antioxidants as mitochondrial protective agents: ATP production and metabolic stability by Chevalier, Arnaud, Alam, Mohammad Parvez, Khdour, Omar M., Schmierer, Margaret, Arce, Pablo M., Cripe, Cameron D., Hecht, Sidney M.

“…[Display omitted] Previously we described a novel series of pyrimidinol antioxidants and their structural optimization as potential therapeutic agents for…”
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Cytoprotective pyridinol antioxidants as potential therapeutic agents for neurodegenerative and mitochondrial diseases by Alam, Mohammad Parvez, Khdour, Omar M., Arce, Pablo M., Chen, Yana, Roy, Basab, Johnson, Walter G., Dey, Sriloy, Hecht, Sidney M.

“…[Display omitted] As part of our ongoing efforts to identify compounds having potential utility in treating neurodegenerative and mitochondrial disorders, a…”
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Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels by Bandyopadhyay, Indrajit, Chowdhury, Sandipan Roy, Visavadiya, Nishant P., Hecht, Sidney M., Khdour, Omar M.

“…As part of an ongoing program to develop potential therapeutic agents for the treatment of the neurodegenerative disease Friedreich׳s ataxia (FRDA), we have…”
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Nuclear but not mitochondrial-encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease by Mastroeni, Diego, Khdour, Omar M., Delvaux, Elaine, Nolz, Jennifer, Olsen, Gary, Berchtold, Nicole, Cotman, Carl, Hecht, Sidney M., Coleman, Paul D.

“…We have comprehensively described the expression profiles of mitochondrial DNA and nuclear DNA genes that encode subunits of the respiratory oxidative…”
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Antiferroptotic Activity of Phenothiazine Analogues: A Novel Therapeutic Strategy for Oxidative Stress Related Disease by Liu, Jun, Bandyopadhyay, Indrajit, Zheng, Lei, Khdour, Omar M, Hecht, Sidney M

“…Ferroptosis is an iron-catalyzed, nonapoptotic form of regulated necrosis that has been implicated in the pathological cell death associated with various…”
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Lipophilic methylene blue analogues enhance mitochondrial function and increase frataxin levels in a cellular model of Friedreich’s ataxia by Khdour, Omar M., Bandyopadhyay, Indrajit, Chowdhury, Sandipan Roy, Visavadiya, Nishant P., Hecht, Sidney M.

“…[Display omitted] Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disorder resulting from reduced expression of the protein frataxin…”
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Lipophilic methylene violet analogues as modulators of mitochondrial function and dysfunction by Roy Chowdhury, Sandipan, Khdour, Omar M., Bandyopadhyay, Indrajit, Hecht, Sidney M.

“…[Display omitted] In an effort to identify methylene blue analogues having improved antioxidant activity, a series of new methylene violet analogues have been…”
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An assay for DNA polymerase β lyase inhibitors that engage the catalytic nucleophile for binding by Daskalova, Sasha M., Eisenhauer, Brian M., Gao, Mingxuan, Feng, Xizhi, Ji, Xun, Cheng, Qi, Fahmi, NourEddine, Khdour, Omar M., Chen, Shengxi, Hecht, Sidney M.

“…[Display omitted] DNA polymerase β (Pol β) repairs cellular DNA damage. When such damage is inflicted upon the DNA in tumor cells treated with DNA targeted…”
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Multifunctional radical quenchers as potential therapeutic agents for the treatment of mitochondrial dysfunction by Ji, Xun, Khdour, Omar M, Hecht, Sidney M

“…Mitochondrial dysfunction is associated with a wide range of human diseases, including neurodegenerative diseases, and is believed to cause or contribute to…”
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Influence of substituent heteroatoms on the cytoprotective properties of pyrimidinol antioxidants by Chevalier, Arnaud, Khdour, Omar M., Schmierer, Margaret, Bandyopadhyay, Indrajit, Hecht, Sidney M.

“…[Display omitted] Recently, we described the optimization of novel pyrimidinol-based antioxidants as potential therapeutic molecules for targeting…”
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Oligomeric amyloid β preferentially targets neuronal and not glial mitochondrial-encoded mRNAs by Mastroeni, Diego, Nolz, Jennifer, Khdour, Omar M., Sekar, Shobana, Delvaux, Elaine, Cuyugan, Lori, Liang, Winnie S., Hecht, Sidney M., Coleman, Paul D.

“…Our laboratories have demonstrated that accumulation of oligomeric amyloid β (OAβ) in neurons is an essential step leading to OAβ-mediated mitochondrial…”
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Inhibition of Human Cancer Cell Growth by Analogues of Antimycin A by Zhang, Yanmin, Chevalier, Arnaud, Khdour, Omar M, Soto, Larisa Morales, Hecht, Sidney M

“…In a recent study, several new derivatives of antimycin A (AMA) were produced by means of a novel transacylation reaction, and these were shown to mediate…”
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An Acetate Prodrug of a Pyridinol-Based Vitamin E Analogue by Khdour, Omar M., Lu, Jun, Hecht, Sidney M.

“…ABSTRACT Purpose To investigate of an approach to stabilize a novel pyridinol based α–tocopherol analogue (1) as a prodrug by acetylation of its phenol moiety…”
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Phenothiazine antioxidants increase mitochondrial biogenesis and frataxin levels in Friedreich's ataxia cells by Khdour, Omar M, Bandyopadhyay, Indrajit, Visavadiya, Nishant P, Roy Chowdhury, Sandipan, Hecht, Sidney M

“…Friedreich's ataxia (FRDA) is a progressive neurodegenerative disease that is linked to transcriptional repression of the nuclear FXN gene encoding the…”
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Simplified bicyclic pyridinol analogues protect mitochondrial function by Cai, Xiaoqing, Khdour, Omar M., Jaruvangsanti, Jennifer, Hecht, Sidney M.

“…Bicyclic pyridinol antioxidants have been reported to suppress the autoxidation of methyl linoleate more effectively than α-tocopherol in benzene solution. A…”
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Synthesis and Biological Activities of N‑(3-Carboxylpropyl)-5-amino-2-hydroxy-3-tridecyl-1,4-benzoquinone and Analogues by Madathil, Manikandadas M, Khdour, Omar M, Jaruvangsanti, Jennifer, Hecht, Sidney M

“…The synthesis of benzoquinone natural product 2 and three analogues is described. The synthesized compounds were tested for their ability to protect…”
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Novel Antioxidants Protect Mitochondria from the Effects of Oligomeric Amyloid Beta and Contribute to the Maintenance of Epigenome Function by Mastroeni, Diego, Khdour, Omar M, Arce, Pablo M, Hecht, Sidney M, Coleman, Paul D

“…Alzheimer’s disease is associated with metabolic deficits and reduced mitochondrial function, with the latter due to the effects of oligomeric amyloid beta…”
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