Carcinoid heart disease revealed by cyanosis with both right and left valvular involvement: a case report

Carcinoid heart disease is a frequent complication of carcinoid syndrome. It is related to the release by the carcinoid tumor and/or its metastases of bioactive substances such as serotonin. It is characterized by right-sided valvular involvement and can lead to right-sided heart failure. It is a pr...

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Bibliographic Details
Published in:	Journal of medical case reports Vol. 12; no. 1; p. 23
Main Authors:	Khay, Khadija, Arous, Salim, Bentaoune, Tarik, Drighil, Abdenasser, Habbal, Rachida
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 31-01-2018 BioMed Central BMC
Subjects:	Analysis Carcinoid Heart Disease - diagnosis Carcinoid Heart Disease - physiopathology Carcinoid syndrome Carcinoid tumor Carcinoid tumors Cardiac surgery Cardiac Surgical Procedures Case Report Comorbidity Cyanosis Diagnosis Echocardiography Female Fibrosis Foramen Ovale, Patent - diagnostic imaging Foramen Ovale, Patent - pathology Heart Failure - diagnostic imaging Heart Failure - pathology Heart Failure - surgery Hormones - therapeutic use Humans Intestinal Neoplasms - diagnostic imaging Intestinal Neoplasms - therapy Middle Aged Somatostatin - therapeutic use Treatment Outcome Carcinoid tumors Cardiac surgery Carcinoid syndrome Fibrosis
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Summary:	Carcinoid heart disease is a frequent complication of carcinoid syndrome. It is related to the release by the carcinoid tumor and/or its metastases of bioactive substances such as serotonin. It is characterized by right-sided valvular involvement and can lead to right-sided heart failure. It is a prognostic factor of carcinoid syndrome. We report the case of a 53-year-old African woman with an endocrine tumor of her small intestine complicated by carcinoid heart disease, revealed by right-sided heart failure. The diagnosis was confirmed by transthoracic echocardiography, which showed a severe tricuspid regurgitation with a patent foramen ovale, and by increased serum chromogranin A and urinary 5-hydroxyindoleacetic acid. Initially she was treated with medical therapy (furosemide and injection of somatostatin). Afterwards she was proposed for surgery. The evolution of her treatment was good. Carcinoid syndrome is complicated in 60% of the cases of a heart disease, and is responsible for an important morbidity and mortality. The prognosis of patients with carcinoid heart disease has improved in recent years through somatostatin analogues and the cardiac surgery.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1752-1947 1752-1947
DOI:	10.1186/s13256-018-1574-6