Search Results - "Khawli, Leslie"

Brain Disposition of Antibody-Based Therapeutics: Dogma, Approaches and Perspectives by Kouhi, Aida, Pachipulusu, Vyshnavi, Kapenstein, Talya, Hu, Peisheng, Epstein, Alan L., Khawli, Leslie A.

“…Due to their high specificity, monoclonal antibodies have been widely investigated for their application in drug delivery to the central nervous system (CNS)…”
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Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development by Tibbitts, Jay, Canter, David, Graff, Ryan, Smith, Alison, Khawli, Leslie A.

“…Protein therapeutics represent a diverse array of biologics including antibodies, fusion proteins, and therapeutic replacement enzymes. Since their inception,…”
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Advances in Immuno-PET for the Detection of Cancer and Assessment of Response to Therapy by Alauddin, Mian M, Khawli, Leslie A

“…Monoclonal antibodies (mAbs) against tumor-associated antigens have been shown to target tumors with specificity and selectivity; therefore, it was…”
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Principles of N-Linked Glycosylation Variations of IgG-Based Therapeutics: Pharmacokinetic and Functional Considerations by Boune, Souad, Hu, Peisheng, Epstein, Alan L., Khawli, Leslie A.

“…The development of recombinant therapeutic proteins has been a major revolution in modern medicine. Therapeutic-based monoclonal antibodies (mAbs) are growing…”
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Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics by Boswell, C. Andrew, Tesar, Devin B., Mukhyala, Kiran, Theil, Frank-Peter, Fielder, Paul J., Khawli, Leslie A.

“…Antibody pharmacokinetics and pharmacodynamics are often governed by biological processes such as binding to antigens and other cognate receptors. Emphasis…”
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Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates by Shen, Ben-Quan, Xu, Keyang, Liu, Luna, Raab, Helga, Bhakta, Sunil, Kenrick, Margaret, Parsons-Reponte, Kathryn L, Tien, Janet, Yu, Shang-Fan, Mai, Elaine, Li, Dongwei, Tibbitts, Jay, Baudys, Jakub, Saad, Ola M, Scales, Suzie J, McDonald, Paul J, Hass, Philip E, Eigenbrot, Charles, Nguyen, Trung, Solis, Willy A, Fuji, Reina N, Flagella, Kelly M, Patel, Darshana, Spencer, Susan D, Khawli, Leslie A, Ebens, Allen, Wong, Wai Lee, Vandlen, Richard, Kaur, Surinder, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul, Junutula, Jagath R

“…Conjugating drugs to therapeutic antibodies is a promising strategy to increase their therapeutic efficacy. Shen et al. show that the local chemical…”
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A Humanized Lym-1 CAR with Novel DAP10/DAP12 Signaling Domains Demonstrates Reduced Tonic Signaling and Increased Antitumor Activity in B-Cell Lymphoma Models by Zheng, Long, Ren, Luqing, Kouhi, Aida, Khawli, Leslie A, Hu, Peisheng, Kaslow, Harvey R, Epstein, Alan L

“…The murine Lym-1 mAb targets a discontinuous epitope (Lym-1 epitope) on several subtypes of HLA-DR, which is upregulated in a majority of human B-cell…”
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Drug Delivery across the Blood–Brain Barrier by Khawli, Leslie A, Prabhu, Saileta

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Enhancing brain entry and therapeutic activity of chimeric antigen receptor T cells with intra-arterial NEO100 in a mouse model of CNS lymphoma by Wang, Weijun, He, Haiping, Zheng, Long, Zeng, Shan, Cho, Hee-Yeon, Kouhi, Aida, Khawli, Leslie A, Chen, Ligang, Stathopoulos, Apostolos, Schönthal, Axel H, Epstein, Alan L, Chen, Thomas C

“…Malignancies of the CNS are difficult to treat because the blood-brain barrier (BBB) prevents most therapeutics from reaching the intracranial lesions at…”
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Physiochemical and Biochemical Factors Influencing the Pharmacokinetics of Antibody Therapeutics by Bumbaca, Daniela, Boswell, C. Andrew, Fielder, Paul J., Khawli, Leslie A.

“…Monoclonal antibodies are increasingly being developed to treat multiple disease areas, including those related to oncology, immunology, neurology, and…”
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Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats by Khawli, Leslie A., Goswami, Sirj, Hutchinson, Ryan, Kwong, Zephania W., Yang, Jihong, Wang, Xiangdan, Yao, Zhenling, Sreedhara, Alavattam, Cano, Tony, Tesar, Devin B., Nijem, Ihsan, Allison, David E., Wong, Pin Yee, Kao, Yung-Hsiang, Quan, Cynthia, Joshi, Amita, Harris, Reed J., Motchnik, Paul

“…Antibody charge variants have gained considerable attention in the biotechnology industry due to their potential influence on stability and biological…”
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Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics by Bumbaca Yadav, Daniela, Sharma, Vikas K., Boswell, Charles Andrew, Hotzel, Isidro, Tesar, Devin, Shang, Yonglei, Ying, Yong, Fischer, Saloumeh K., Grogan, Jane L., Chiang, Eugene Y., Urban, Konnie, Ulufatu, Sheila, Khawli, Leslie A., Prabhu, Saileta, Joseph, Sean, Kelley, Robert F.

“…The pharmacokinetic (PK) behavior of monoclonal antibodies in cynomolgus monkeys (cynos) is generally translatable to that in humans. Unfortunately, about 39%…”
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Impact of Drug Conjugation on Pharmacokinetics and Tissue Distribution of Anti-STEAP1 Antibody–Drug Conjugates in Rats by Boswell, C. Andrew, Mundo, Eduardo E, Zhang, Crystal, Bumbaca, Daniela, Valle, Nicole R, Kozak, Katherine R, Fourie, Aimee, Chuh, Josefa, Koppada, Neelima, Saad, Ola, Gill, Herman, Shen, Ben-Quan, Rubinfeld, Bonnee, Tibbitts, Jay, Kaur, Surinder, Theil, Frank-Peter, Fielder, Paul J, Khawli, Leslie A, Lin, Kedan

“…Antibody–drug conjugates (ADCs) are designed to combine the exquisite specificity of antibodies to target tumor antigens with the cytotoxic potency of…”
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A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components by Kinnunen, Hanne M., Sharma, Vikas, Contreras-Rojas, Luis Rodrigo, Yu, Yafei, Alleman, Chlöe, Sreedhara, Alavattam, Fischer, Stefan, Khawli, Leslie, Yohe, Stefan T., Bumbaca, Daniela, Patapoff, Thomas W., Daugherty, Ann L., Mrsny, Randall J.

“…Subcutaneous (SC) injection is becoming a more common route for the administration of biopharmaceuticals. Currently, there is no reliable in vitro method that…”
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Spatio-temporal biodistribution of 89Zr-oxine labeled huLym-1-A-BB3z-CAR T-cells by PET imaging in a preclinical tumor model by Sta Maria, Naomi S., Khawli, Leslie A., Pachipulusu, Vyshnavi, Lin, Sharon W., Zheng, Long, Cohrs, Daniel, Liu, Xiaodan, Hu, Peisheng, Epstein, Alan L., Jacobs, Russell E.

“…Quantitative in vivo monitoring of cell biodistribution offers assessment of treatment efficacy in real-time and can provide guidance for further optimization…”
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Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins by Theil, Frank-Peter, Epstein, Alan L., Frutoz, Kimberley, Jaw, Stacey, Manoli, Hugh, Smith, Alison, Khawli, Leslie A.

“…Biologics have emerged as a powerful and diverse class of molecular and cell-based therapies that are capable of replacing enzymes, editing genomes, targeting…”
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Characterization of Therapeutic Monoclonal Antibodies Reveals Differences Between In Vitro and In Vivo Time-Course Studies by Yin, Sheng, Pastuskovas, Cinthia V., Khawli, Leslie A., Stults, John T.

“…ABSTRACT Purpose To examine and determine the sites and the kinetics of IgG1 mAb modifications from both in vitro (rat plasma and PBS) and in vivo (rat model)…”
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Lym-1 Chimeric Antigen Receptor T Cells Exhibit Potent Anti-Tumor Effects against B-Cell Lymphoma by Zheng, Long, Hu, Peisheng, Wolfe, Brandon, Gonsalves, Caryn, Ren, Luqing, Khawli, Leslie A, Kaslow, Harvey R, Epstein, Alan L

“…T cells expressing chimeric antigen receptors (CARs) recognizing CD19 epitopes have produced remarkable anti-tumor effects in patients with B-cell…”
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Compartmental Tissue Distribution of Antibody Therapeutics: Experimental Approaches and Interpretations by Boswell, C. Andrew, Bumbaca, Daniela, Fielder, Paul J., Khawli, Leslie A.

“…Monoclonal antibodies have provided many validated and potential new therapeutic candidates for various diseases encompassing the realms of neurology,…”
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Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer by Boswell, C. Andrew, Yadav, Daniela Bumbaca, Mundo, Eduardo E., Yu, Shang-Fan, Lacap, Jennifer Arca, Fourie-O’Donohue, Aimee, Kozak, Katherine R., Ferl, Gregory Z., Zhang, Crystal, Ho, Jason, Ulufatu, Sheila, Khawli, Leslie A., Lin, Kedan

“…TENB2, a transmembrane proteoglycan protein, is a promising target for antibody drug conjugate (ADC) therapy due to overexpression in human prostate tumors and…”
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