Search Results - "Khaw, S L"

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells by Xu, Z, Sharp, P P, Yao, Y, Segal, D, Ang, C H, Khaw, S L, Aubrey, B J, Gong, J, Kelly, G L, Herold, M J, Strasser, A, Roberts, A W, Alexander, W S, Burns, C J, Huang, D C S, Glaser, S P

“…The BET ( b romodomain and e xtra t erminal domain) bromodomain-containing proteins, such as BRD4, are highly promising targets for treating lymphoid and…”
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The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia by Mason, K D, Khaw, S L, Rayeroux, K C, Chew, E, Lee, E F, Fairlie, W D, Grigg, A P, Seymour, J F, Szer, J, Huang, D C S, Roberts, A W

“…As chronic lymphocytic leukemia (CLL) is characterized by overexpression of pro-survival BCL2, compounds that mimic its physiological antagonists, the BH3-only…”
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Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199 by Khaw, S L, Mérino, D, Anderson, M A, Glaser, S P, Bouillet, P, Roberts, A W, Huang, D C S

“…Overexpression of the prosurvival protein Bcl-2 marks many B-lymphoid malignancies and contributes to resistance to many commonly used chemotherapeutic agents…”
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S255: EFFICACY AND SAFETY OF TISAGENLECLEUCEL IN PEDIATRIC AND YOUNG ADULT PATIENTS (PTS) WITH RELAPSED OR REFRACTORY (R/R) MATURE B‐CELL NON‐HODGKIN LYMPHOMA (NHL): THE PHASE II BIANCA STUDY by Minard‐Colin, V., Buechner, J., Locatelli, F., Gonzalez Martinez, B., Vormoor, B. J., Cooper, S., Krueger, J., Napolitano, S., Attarbaschi, A., Baruchel, A., Ghorashian, S., Hermiston, M. L., Hiramatsu, H., Ifversen, M., John, S., Khaw, S. L., O'Brien, T. A., Phillips, C. L., Diaz de Heredia, C., Tomizawa, D., Vettenranta, K., Wayne, A. S., Newsome, S., Awasthi, R., Redondo, S., Masood, A., Maude, S. L., Burkhardt, B.

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S112: TISAGENLECLEUCEL IN PEDIATRIC AND YOUNG ADULT PATIENTS (PTS) WITH RELAPSED/REFRACTORY (R/R) B‐CELL ACUTE LYMPHOBLASTIC LEUKEMIA (B‐ALL): FINAL ANALYSES FROM THE ELIANA STUDY by Rives, S., Maude, S. L., Hiramatsu, H., Baruchel, A., Bader, P., Bittencourt, H., Buechner, J., Laetsch, T., De Moerloose, B., Qayed, M., Stefanski, H. E., Davis, K. L., Martin, P. L., Nemecek, E., Peters, C., Yanik, G., Balduzzi, A., Boissel, N., Khaw, S. L., Krueger, J., Levine, J., Davies, S., Myers, G. D., Yeo, A., O'Donovan, D., Ramos, R., Pulsipher, M., Grupp, S.

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Bowel imbrication in the management of anorectal anomalies by Dewan, P A, Elsworthy, E, Mathew, M, Poki, O, Khaw, S L, Roberts, K, Catto-Smith, A

“…Four patients who had imbrication of their proximal rectum and distal sigmoid colon as part of the management of constipation following an anorectoplasty for…”
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The Eµ-TCL-1 mouse model of chronic lymphocytic leukemia by Chin, HS, Egle, A, Khaw, SL, VanDelft, MF, Huang, DC

“…Background: Chronic lymphocytic leukemia (CLL) is a heterogenous disease characterized by the accumulation of CD5+/CD19+ B cells in all lymphoid compartments…”
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A novel MYB::PAIP1 oncogenic fusion in pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is dependent on BCL2 expression and is sensitive to venetoclax by Kosasih, Hansen J., Healey, Gerry, Brennan, Margs S., Bjelosevic, Stefan, Sadras, Teresa, Jalud, Fatimah B., Ibnat, Tasnia, Ng, Ashley P., Mayoh, Chelsea, Mao, Jie, Tax, Gabor, Ludlow, Louise E. A., Johnstone, Ricky W., Herold, Marco J., Khaw, Seong L., Bock, Charles E., Ekert, Paul G.

“…The huMCL1 mouse strain (human MCL1 gene knocked -into the murine Mcl1 locus) is phenotypically indistinguishable from wild-type C57BL/6 (WT). To determine…”
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