Search Results - "Khatri, Ismat"

Toll-like Receptor 2 Activation Promotes Tumor Dendritic Cell Dysfunction by Regulating IL-6 and IL-10 Receptor Signaling by Tang, Michael, Diao, Jun, Gu, Hongtao, Khatri, Ismat, Zhao, Jun, Cattral, Mark S.

“…Although dendritic cell (DC) dysfunction in cancer is a well-recognized consequence of cancer-associated inflammation that contributes to immune evasion, the…”
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Importance of CD200 expression by tumor or host cells to regulation of immunotherapy in a mouse breast cancer model by Curry, Anna, Khatri, Ismat, Kos, Olha, Zhu, Fang, Gorczynski, Reginald

“…Cell-surface CD200 expression by mouse EMT6 breast tumor cells increased primary tumor growth and metastasis to the draining lymph nodes (DLN) in normal (WT)…”
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Targeting T-cell malignancies using allogeneic double-negative CD4-CAR-T cells by Fang, Karen Kai-Lin, Lee, Jongbok, Khatri, Ismat, Zhang, Li

“…Background Patients with relapsed/refractory T-cell malignancies have limited treatment options. The use of chimeric antigen receptor (CAR)-T cell therapy for…”
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Comparison of immunity in mice cured of primary/metastatic growth of EMT6 or 4THM breast cancer by chemotherapy or immunotherapy by Gorczynski, Reginald M, Chen, Zhiqi, Erin, Nuray, Khatri, Ismat, Podnos, Anna

“…We have compared cure from local/metastatic tumor growth in BALB/c mice receiving EMT6 or the poorly immunogenic, highly metastatic 4THM, breast cancer cells…”
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Characterization of CD200 Ectodomain Shedding by Wong, Karrie K, Zhu, Fang, Khatri, Ismat, Huo, Qiang, Spaner, David E, Gorczynski, Reginald M

“…We have previously reported the existence of a soluble form of CD200 (sCD200) in human plasma, and found sCD200 to be elevated in the plasma of Chronic…”
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Ectodomain shedding of CD200 from the B-CLL cell surface is regulated by ADAM28 expression by Twito, Tal, Chen, Zhiqi, Khatri, Ismat, Wong, Karrie, Spaner, David, Gorczynski, Reg

“…Abstract CD200, a membrane glycoprotein of the immunoglobulin superfamily, is overexpressed in CLL. Soluble in serum CD200 (sCD200) is correlated with poor…”
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A Synthetic Cross-Species CD200R1 Agonist Suppresses Inflammatory Immune Responses In Vivo by Prodeus, Aaron, Sparkes, Amanda, Fischer, Nicholas W., Cydzik, Marzena, Huang, Eric, Khatri, Ismat, Young, Ashley, Woo, Lindsay, Chow, Chung Wai, Gorczynski, Reginald, Gariépy, Jean

“…Functional aptamers displaying agonistic or antagonistic properties are showing great promise as modulators of immune responses. Here, we report the…”
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The role of CD200 in immunity to B cell lymphoma by Wong, Karrie K., Khatri, Ismat, Shaha, Suchinta, Spaner, David E., Gorczynski, Reginald M.

“…CD200 expression on lymphoma/CLL cells, or in CLL serum, suppresses immunity yet is overcome by neutralizing antibody, siRNAs, or absorption of CD200 from…”
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Agonistic CD200R1 DNA Aptamers Are Potent Immunosuppressants That Prolong Allogeneic Skin Graft Survival by Prodeus, Aaron, Cydzik, Marzena, Abdul-Wahid, Aws, Huang, Eric, Khatri, Ismat, Gorczynski, Reginald, Gariépy, Jean

“…CD200R1 expressed on the surface of myeloid and lymphoid cells delivers immune inhibitory signals to modulate inflammation when engaged with its ligand CD200…”
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Peptides of CD200 Modulate LPS-Induced TNF-α Induction and Mortality In Vivo by Gorczynski, Reg, M.D., Ph.D, Boudakov, Ivo, Ph.D, Khatri, Ismat, Ph.D

“…Interaction of the ubiquitously expressed molecule CD200 with its receptor(s) CD200R, expressed on cells of myeloid and lymphoid origin, delivers…”
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Identification of an Expressed Truncated Form of CD200, CD200tr, which is a Physiologic Antagonist of CD200-Induced Suppression by ZHIQI CHEN, CHEN, Dang-Xiao, YU KAI, KHATRI, Ismat, LAMPTEY, Brent, GORCZYNSKI, Reginald M

“…Earlier studies have indicated that cell surface expressed CD200, or a soluble form of this molecule, can induce immunosuppression in a number of biological…”
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N-linked oligosaccharides play a role in disulphide-dependent dimerization of intestinal mucin Muc2 by Bell, Sherilyn L, Xu, Gongqiao, Khatri, Ismat A, Wang, Rongquan, Rahman, Sameera, Forstner, Janet F

“…Within the C-terminal domain of many secretory mucins is a 'cystine knot' (CK), which is needed for dimer formation in the endoplasmic reticulum. Previous…”
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C-terminal domain of rodent intestinal mucin Muc3 is proteolytically cleaved in the endoplasmic reticulum to generate extracellular and membrane components by Wang, Rongquan, Khatri, Ismat A, Forstner, Janet F

“…Although human MUC3 and rodent Muc3 are both membrane-associated intestinal mucins, the present study has explored the possibility that rodent Muc3 might exist…”
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SEA (sea-urchin sperm protein, enterokinase and agrin)-module cleavage, association of fragments and membrane targeting of rat intestinal mucin Muc3 by Khatri, Ismat A, Wang, Rongquan, Forstner, Janet F

“…In a previous study we showed, by transient expression studies in COS-1 cells, that the C-terminal domain of rat intestinal membrane mucin Muc3 was cleaved…”
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A comparison of the biological properties of small molecular weight agonists and antagonists of CD200:CD200R interactions by Gorczynski, Reg, Boudakov, Ivo, Khatri, Ismat

“…Our laboratory and others have documented in some detail the immunological consequences which follow from interaction of the ubiquitously expressed molecule…”
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Effect of chondroitinase ABC on purulent sputum from cystic fibrosis and other patients by KHATRI, Ismat A, RAMAKRISHNAN BHASKAR, K, LAMONT, J. Thomas, UMADEVI SAJJAN, S, HO, Catherine K. Y, FORSTNER, Janet

“…Cystic fibrosis (CF) patients develop chronic lung infections associated with airway obstruction by viscous and insoluble mucus secretions. Although mucus…”
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Characterization of Peptide Agonists and Antagonists for the Interaction of CD200 with CD200r1 and Their Efficacy in Modulation of LPS-induced TNFα Production and Mortality In Vivo by Gorczynski, Reginald, Professor, University Health Network, Toronto, ON, Canada, Boudakov, Ivo, PDF, University Health Network, Toronto, ON, Canada, Khatri, Ismat, PDF, University Health Network, Toronto, ON, Canada

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Evidence for a second peptide cleavage in the C-terminal domain of rodent intestinal mucin Muc3 by Khatri, Ismat A, Wang, Rongquan, Forstner, Janet F

“…Rat intestinal mucin Muc3 (rMuc3), like its human homologue (MUC3) and several other membrane mucins, contains a C-terminally located SEA (sea urchin sperm…”
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Allogeneic double-negative CAR-T cells inhibit tumor growth without off-tumor toxicities by Vasic, Daniel, Lee, Jong Bok, Leung, Yuki, Khatri, Ismat, Na, Yoosu, Abate-Daga, Daniel, Zhang, Li

“…The development of autologous chimeric antigen receptor T (CAR-T) cell therapies has revolutionized cancer treatment. Nevertheless, the delivery of CAR-T cell…”
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Immunization of CD200R1KO mice post surgical resection of EMT6 breast cancer leads to long-term (>1year) cure of metastatic tumor growth (TUM2P.1022) by Gorczynski, R., Khatri, Ismat, Podnos, Anna

“…Abstract Attenuated expression of CD200 decreases local tumor growth and metastasis in immunocompetent animals. We explored the ability to cure BALB/c CD200KO…”
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