Search Results - "Khatri, Bhavin S"

Comparison of loop extrusion and diffusion capture as mitotic chromosome formation pathways in fission yeast by Gerguri, Tereza, Fu, Xiao, Kakui, Yasutaka, Khatri, Bhavin S, Barrington, Christopher, Bates, Paul A, Uhlmann, Frank

“…Underlying higher order chromatin organization are Structural Maintenance of Chromosomes (SMC) complexes, large protein rings that entrap DNA. The molecular…”
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Biophysics and population size constrains speciation in an evolutionary model of developmental system drift by Khatri, Bhavin S, Goldstein, Richard A

“…Developmental system drift is a likely mechanism for the origin of hybrid incompatibilities between closely related species. We examine here the detailed…”
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Fission yeast condensin contributes to interphase chromatin organization and prevents transcription-coupled DNA damage by Kakui, Yasutaka, Barrington, Christopher, Barry, David J, Gerguri, Tereza, Fu, Xiao, Bates, Paul A, Khatri, Bhavin S, Uhlmann, Frank

“…Structural maintenance of chromosomes (SMC) complexes are central organizers of chromatin architecture throughout the cell cycle. The SMC family member…”
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Optimal chemotactic responses in stochastic environments by Godány, Martin, Khatri, Bhavin S, Goldstein, Richard A

“…Although the "adaptive" strategy used by Escherichia coli has dominated our understanding of bacterial chemotaxis, the environmental conditions under which…”
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A theory of resistance to multiplexed gene drive demonstrates the significant role of weakly deleterious natural genetic variation by Khatri, Bhavin S, Burt, Austin

“…Evolution of resistance is a major barrier to successful deployment of gene-drive systems to suppress natural populations, which could greatly reduce the…”
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Entropy and Barrier-Controlled Fluctuations Determine Conformational Viscoelasticity of Single Biomolecules by Khatri, Bhavin S., Kawakami, Masaru, Byrne, Katherine, Smith, D. Alastair, McLeish, Tom C.B.

“…Biological macromolecules have complex and nontrivial energy landscapes, endowing them with a unique conformational adaptability and diversity in function…”
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Robust Estimation of Recent Effective Population Size from Number of Independent Origins in Soft Sweeps by Khatri, Bhavin S, Burt, Austin

“…Abstract Estimating recent effective population size is of great importance in characterizing and predicting the evolution of natural populations. Methods…”
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Dynamics of the Coiled-Coil Unfolding Transition of Myosin Rod Probed by Dissipation Force Spectrum by Taniguchi, Yukinori, Khatri, Bhavin S., Brockwell, David J., Paci, Emanuele, Kawakami, Masaru

“…The motor protein myosin II plays a crucial role in muscle contraction. The mechanical properties of its coiled-coil region, the myosin rod, are important for…”
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Quantifying evolutionary dynamics from variant-frequency time series by Khatri, Bhavin S.

“…From Kimura’s neutral theory of protein evolution to Hubbell’s neutral theory of biodiversity, quantifying the relative importance of neutrality versus…”
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Statistical mechanics of convergent evolution in spatial patterning by Khatri, Bhavin S, McLeish, Tom C.B, Sear, Richard P

“…We explore how the genotype-phenotype map determines convergent evolution in a simple model of spatial gene regulation during development. Evolution is…”
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Internal friction of single polypeptide chains at high stretch by Khatri, Bhavin S, Byrne, Katherine, Kawakami, Masaru, Brockwell, David J, Smith, D Alastair, Radford, Sheena E, McLeish, Tom C B

“…Experiments that measure the viscoelasticity of single molecules from the Brownian fluctuations of an atomic force microscope (AFM) have provided a new window…”
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Simple Biophysical Model Predicts Faster Accumulation of Hybrid Incompatibilities in Small Populations Under Stabilizing Selection by Khatri, Bhavin S, Goldstein, Richard A

“…Speciation is fundamental to the process of generating the huge diversity of life on Earth. However, we are yet to have a clear understanding of its…”
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Viscoelastic Measurements of Single Molecules on a Millisecond Time Scale by Magnetically Driven Oscillation of an Atomic Force Microscope Cantilever by Kawakami, Masaru, Byrne, Katherine, Khatri, Bhavin S, Mcleish, Tom C. B, Radford, Sheena E, Smith, D. Alastair

“…The dynamical nature of biomolecular systems means that knowledge of their viscoelastic behavior is important in fully understanding function. The linear…”
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From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics by Manrubia, Susanna, Cuesta, José A., Aguirre, Jacobo, Ahnert, Sebastian E., Altenberg, Lee, Cano, Alejandro V., Catalán, Pablo, Diaz-Uriarte, Ramon, Elena, Santiago F., García-Martín, Juan Antonio, Hogeweg, Paulien, Khatri, Bhavin S., Krug, Joachim, Louis, Ard A., Martin, Nora S., Payne, Joshua L., Tarnowski, Matthew J., Weiß, Marcel

“…•Understanding of how genotypes map onto molecular phenotypes and organismal functions is partial.•The networked organization of genotype-phenotype (GP) maps…”
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A coarse-grained biophysical model of sequence evolution and the population size dependence of the speciation rate by Khatri, Bhavin S., Goldstein, Richard A.

“…Speciation is fundamental to understanding the huge diversity of life on Earth. Although still controversial, empirical evidence suggests that the rate of…”
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Multiple-Line Inference of Selection on Quantitative Traits by Riedel, Nico, Khatri, Bhavin S, Lässig, Michael, Berg, Johannes

“…Trait differences between species may be attributable to natural selection. However, quantifying the strength of evidence for selection acting on a particular…”
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Viscoelastic Properties of Single Poly(ethylene glycol) Molecules by Kawakami, Masaru, Byrne, Katherine, Khatri, Bhavin S., McLeish, Tom C. B., Smith, D. Alastair

“…The viscoelastic properties of single poly(ethylene glycol) (PEG) molecules were measured by analysis of thermally and magnetically driven oscillations of an…”
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Rouse Model with Internal Friction:  A Coarse Grained Framework for Single Biopolymer Dynamics by Khatri, Bhavin S, McLeish, Tom C. B

“…Recent work has highlighted an intimate link between the internal friction of single biopolymers and dynamics on an underlying energy landscape of…”
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Oscillating microbial dynamics driven by small populations, limited nutrient supply and high death rates by Khatri, Bhavin S., Free, Andrew, Allen, Rosalind J.

“…Predicting and controlling the behaviour of microbial ecosystems demands a fundamental understanding of the factors controlling their dynamics. In the natural…”
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The long and winding road to understanding organismal construction: Reply to comments on “From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics” by Manrubia, Susanna, Cuesta, José A., Aguirre, Jacobo, Ahnert, Sebastian E., Altenberg, Lee, Cano, Alejandro V., Catalán, Pablo, Diaz-Uriarte, Ramon, Elena, Santiago F., García-Martín, Juan Antonio, Hogeweg, Paulien, Khatri, Bhavin S., Krug, Joachim, Louis, Ard A., Martin, Nora S., Payne, Joshua L., Tarnowski, Matthew J., Weiß, Marcel

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