Search Results - "Khatib, Abdel‐Majid"

The proprotein convertase furin in cancer: more than an oncogene by He, Zongsheng, Khatib, Abdel-Majid, Creemers, John W. M.

“…Furin is the first discovered proprotein convertase member and is present in almost all mammalian cells. Therefore, by regulating the maturation of a wide…”
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In Silico Investigation of the New UK (B.1.1.7) and South African (501Y.V2) SARS-CoV-2 Variants with a Focus at the ACE2-Spike RBD Interface by Villoutreix, Bruno O, Calvez, Vincent, Marcelin, Anne-Geneviève, Khatib, Abdel-Majid

“…SARS-CoV-2 exploits angiotensin-converting enzyme 2 (ACE2) as a receptor to invade cells. It has been reported that the UK and South African strains may have…”
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Apela promotes blood vessel regeneration and remodeling in zebrafish by Nys, Nicolas, Khatib, Abdel-Majid, Siegfried, Geraldine

“…In contrast to adult mammals, zebrafish display a high capacity to heal injuries and repair damage to various organs. One of the earliest responses to injury…”
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Targeting liver sinusoidal endothelial cells with miR‐20a‐loaded nanoparticles reduces murine colon cancer metastasis to the liver by Marquez, Joana, Fernandez‐Piñeiro, Ines, Araúzo‐Bravo, Marcos J., Poschmann, Gereon, Stühler, Kai, Khatib, Abdel‐Majid, Sanchez, Alejandro, Unda, Fernando, Ibarretxe, Gaskon, Bernales, Irantzu, Badiola, Iker

“…Phenotypic transformation of liver sinusoidal endothelial cells is one of the most important stages of liver metastasis progression. The miRNA effects on liver…”
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The proprotein convertase furin is a pro-oncogenic driver in KRAS and BRAF driven colorectal cancer by He, Zongsheng, Thorrez, Lieven, Siegfried, Geraldine, Meulemans, Sandra, Evrard, Serge, Tejpar, Sabine, Khatib, Abdel-Majid, Creemers, John W. M.

“…Mutations in KRAS and/or BRAF that activate the ERK kinase are frequently found in colorectal cancer (CRC) and drive resistance to targeted therapies…”
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TRP Channels in Angiogenesis and Other Endothelial Functions by Smani, Tarik, Gómez, Luis J, Regodon, Sergio, Woodard, Geoffrey E, Siegfried, Geraldine, Khatib, Abdel-Majid, Rosado, Juan A

“…Angiogenesis is the growth of blood vessels mediated by proliferation, migration, and spatial organization of endothelial cells. This mechanism is regulated by…”
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Inhibition of proprotein convertases activity results in repressed stemness and invasiveness of cancer stem cells in gastric cancer by Zaafour, Anissa, Seeneevassen, Lornella, Nguyen, Tra Ly, Genevois, Coralie, Nicolas, Nour, Sifré, Elodie, Giese, Alban, Porcheron, Chloé, Descarpentrie, Jean, Dubus, Pierre, Khatib, Abdel-Majid, Varon, Christine

“…Background Gastric cancer (GC), the fourth leading cause of cancer-related death worldwide, with most deaths caused by advanced and metastatic disease, has…”
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Proprotein convertases: lessons from knockouts by Scamuffa, Nathalie, Calvo, Fabien, Chrétien, Michel, Seidah, Nabil G, Khatib, Abdel-Majid

“…The physiological role of the subtilisin/kexin-like proprotein convertases (PCs) in rodents has been examined through the use of knockout mice. This review…”
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New Insights into the Reparative Angiogenesis after Myocardial Infarction by Martín-Bórnez, Marta, Falcón, Débora, Morrugares, Rosario, Siegfried, Geraldine, Khatib, Abdel-Majid, Rosado, Juan A, Galeano-Otero, Isabel, Smani, Tarik

“…Myocardial infarction (MI) causes massive loss of cardiac myocytes and injury to the coronary microcirculation, overwhelming the limited capacity of cardiac…”
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Annexin‐A5 and annexin‐A6 silencing prevents metastasis of breast cancer cells in zebrafish by Gounou, Céline, Bouvet, Flora, Liet, Benjamin, Prouzet‐Mauléon, Valérie, d'Agata, Léna, Harté, Etienne, Argoul, Françoise, Siegfried, Géraldine, Iggo, Richard, Khatib, Abdel‐Majid, Bouter, Anthony

“…Background Information During tumor invasion and metastasis processes, cancer cells are exposed to major compressive and shearing forces, due to their…”
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Regulation of the proprotein convertases expression and activity during regenerative angiogenesis: Role of hypoxia-inducible factor (HIF) by Ma, Jia, Evrard, Serge, Badiola, Iker, Siegfried, Geraldine, Khatib, Abdel-Majid

“…Proprotein convertases (PCs) are involved in various physiological and pathological processes ranging from embryogenesis to carcinogenesis. Here, using the…”
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Sulconazole inhibits PD-1 expression in immune cells and cancer cells malignant phenotype through NF-κB and calcium activity repression by Pernot, Simon, Tomé, Mercedes, Galeano-Otero, Isabel, Evrard, Serge, Badiola, Iker, Delom, Frederic, Fessart, Delphine, Smani, Tarik, Siegfried, Geraldine, Villoutreix, Bruno O, Khatib, Abdel-Majid

“…The overexpression of the immunoinhibitory receptor programmed death-1 (PD1) on T-cells is involved in immune evasion in cancer. The use of anti-PD-1/PDL-1…”
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Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer by Quemener, Cathy, Baud, Jessica, Boyé, Kevin, Dubrac, Alexandre, Billottet, Clotilde, Soulet, Fabienne, Darlot, Florence, Dumartin, Laurent, Sire, Marie, Grepin, Renaud, Daubon, Thomas, Rayne, Fabienne, Wodrich, Harald, Couvelard, Anne, Pineau, Raphael, Schilling, Martin, Castronovo, Vincent, Sue, Shih-Che, Clarke, Kim, Lomri, Abderrahim, Khatib, Abdel-Majid, Hagedorn, Martin, Prats, Hervé, Bikfalvi, Andreas

“…The CXCL4 paralog CXCL4L1 is a less studied chemokine that has been suggested to exert an antiangiogenic function. However, CXCL4L1 is also expressed in…”
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Melanoma spheroids grown under neural crest cell conditions are highly plastic migratory/invasive tumor cells endowed with immunomodulator function by Ramgolam, Kiran, Lauriol, Jessica, Lalou, Claude, Lauden, Laura, Michel, Laurence, de la Grange, Pierre, Khatib, Abdel-Majid, Aoudjit, Fawzi, Charron, Dominique, Alcaide-Loridan, Catherine, Al-Daccak, Reem

“…The aggressiveness of melanoma tumors is likely to rely on their well-recognized heterogeneity and plasticity. Melanoma comprises multi-subpopulations of…”
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Role of Furin in Colon Cancer Stem Cells Malignant Phenotype and Expression of LGR5 and NANOG in KRAS and BRAF-Mutated Colon Tumors by Descarpentrie, Jean, Araúzo-Bravo, Marcos J, He, Zongsheng, François, Alexia, González, Álvaro, Garcia-Gallastegi, Patricia, Badiola, Iker, Evrard, Serge, Pernot, Simon, Creemers, John W M, Khatib, Abdel-Majid

“…Proprotein convertases or PCs are known to regulate the malignant phenotype of colon cancer cells by different mechanisms, but their effects on cancer stem…”
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Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1‐driven acute lymphoblastic leukemia by Nguyen, Tra Ly, Nokin, Marie‐Julie, Terés, Silvia, Tomé, Mercedes, Bodineau, Clément, Galmar, Oriane, Pasquet, Jean‐Max, Rousseau, Benoit, Liempd, Sebastian, Falcon‐Perez, Juan Manuel, Richard, Elodie, Muzotte, Elodie, Rezvani, Hamid‐Reza, Priault, Muriel, Bouchecareilh, Marion, Redonnet‐Vernhet, Isabelle, Calvo, Julien, Uzan, Benjamin, Pflumio, Françoise, Fuentes, Patricia, Toribio, Maria L., Khatib, Abdel‐Majid, Soubeyran, Pierre, Murdoch, Piedad del Socorro, Durán, Raúl V.

“…During glutamine sufficiency, both Notch‐positive and Notch‐negative T‐ALL cells promote glutamine catabolism, leading to mammalian target of rapamycin complex…”
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Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFβ-dependent manner and limits osteoarthritis in mice by Lin, Hilène, Hay, Eric, Latourte, Augustin, Funck-Brentano, Thomas, Bouaziz, Wafa, Ea, Hang-Korng, Khatib, Abdel-Majid, Richette, Pascal, Cohen-Solal, Martine

“…Cartilage loss in osteoarthritis (OA) results from altered local production of growth factors and metalloproteases (MMPs). Furin, an enzyme involved in the…”
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mTOR Inhibition via Displacement of Phosphatidic Acid Induces Enhanced Cytotoxicity Specifically in Cancer Cells by Nguyen, Tra-Ly, Nokin, Marie-Julie, Egorov, Maxim, Tomé, Mercedes, Bodineau, Clément, Di Primo, Carmelo, Minder, Lætitia, Wdzieczak-Bakala, Joanna, Garcia-Alvarez, Maria Concepcion, Bignon, Jérôme, Thoison, Odile, Delpech, Bernard, Surpateanu, Georgiana, Frapart, Yves-Michel, Peyrot, Fabienne, Abbas, Kahina, Terés, Silvia, Evrard, Serge, Khatib, Abdel-Majid, Soubeyran, Pierre, Iorga, Bogdan I, Durán, Raúl V, Collin, Pascal

“…The mTOR is a central regulator of cell growth and is highly activated in cancer cells to allow rapid tumor growth. The use of mTOR inhibitors as anticancer…”
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SARAF and Orai1 Contribute to Endothelial Cell Activation and Angiogenesis by Galeano-Otero, Isabel, Del Toro, Raquel, Khatib, Abdel-Majid, Rosado, Juan Antonio, Ordóñez-Fernández, Antonio, Smani, Tarik

“…Angiogenesis is a multistep process that controls endothelial cells (ECs) functioning to form new blood vessels from preexisting vascular beds. This process is…”
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Protective role of systemic furin in immune response-induced arthritis by Lin, Hilène, Ah Kioon, Marie-Dominique, Lalou, Claude, Larghero, Jerome, Launay, Jean-Marie, Khatib, Abdel-Majid, Cohen-Solal, Martine

“…Objective Rheumatoid arthritis (RA) is an autoimmune joint disease associated with chronic inflammation of the synovium that causes profound damage of joints…”
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