Search Results - "Khare, Anupriya"

Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells by Oczypok, Elizabeth A., BS, Milutinovic, Pavle S., MD, PhD, Alcorn, John F., PhD, Khare, Anupriya, PhD, Crum, Lauren T., BS, Manni, Michelle L., PhD, Epperly, Michael W., PhD, Pawluk, Adriane M, Ray, Anuradha, PhD, Oury, Tim D., MD, PhD

“…Background Single nucleotide polymorphisms in the human gene for the receptor for advanced glycation end-products (RAGE) are associated with an increased…”
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The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia by Chakraborty, Krishnendu, Raundhal, Mahesh, Chen, Bill B., Morse, Christina, Tyurina, Yulia Y., Khare, Anupriya, Oriss, Timothy B., Huff, Rachael, Lee, Janet S., St. Croix, Claudette M., Watkins, Simon, Mallampalli, Rama K., Kagan, Valerian E., Ray, Anuradha, Ray, Prabir

“…Bacterial pneumonia is a significant healthcare burden worldwide. Failure to resolve inflammation after infection precipitates lung injury and an increase in…”
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TNF-α from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection by Fei, Mingjian, Bhatia, Shikha, Oriss, Timothy B., Yarlagadda, Manohar, Khare, Anupriya, Akira, Shizuo, Saijo, Shinobu, Iwakura, Yoichiro, Junecko, Beth A. Fallert, Reinhart, Todd A., Foreman, Oded, Ray, Prabir, Kolls, Jay, Ray, Anuradha, Beutler, Bruce

“…Aspergillus fumigatus is commonly associated with allergic bronchopulmonary aspergillosis in patients with severe asthma in which chronic airway neutrophilia…”
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Mitochondrial H2O2 in Lung Antigen-Presenting Cells Blocks NF-κB Activation to Prevent Unwarranted Immune Activation by Khare, Anupriya, Raundhal, Mahesh, Chakraborty, Krishnendu, Das, Sudipta, Corey, Catherine, Kamga, Christelle K., Quesnelle, Kelly, St. Croix, Claudette, Watkins, Simon C., Morse, Christina, Oriss, Timothy B., Huff, Rachael, Hannum, Rachel, Ray, Prabir, Shiva, Sruti, Ray, Anuradha

“…Inhalation of environmental antigens such as allergens does not always induce inflammation in the respiratory tract. While antigen-presenting cells (APCs),…”
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Pleiotropic consequences of Bruton tyrosine kinase deficiency in myeloid lineages lead to poor inflammatory responses by Mangla, Anita, Khare, Anupriya, Vineeth, Varanasi, Panday, Nagesh Narayan, Mukhopadhyay, Asok, Ravindran, Balachandran, Bal, Vineeta, George, Anna, Rath, Satyajit

“…Bruton tyrosine kinase (Btk), a non-receptor-associated tyrosine kinase of the Tec family, appears to participate in many myeloid cell functions. We show that…”
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High IFN-γ and low SLPI mark severe asthma in mice and humans by Raundhal, Mahesh, Morse, Christina, Khare, Anupriya, Oriss, Timothy B, Milosevic, Jadranka, Trudeau, John, Huff, Rachael, Pilewski, Joseph, Holguin, Fernando, Kolls, Jay, Wenzel, Sally, Ray, Prabir, Ray, Anuradha

“…Severe asthma (SA) is a challenge to control, as patients are not responsive to high doses of systemic corticosteroids (CS). In contrast, mild-moderate asthma…”
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Cutting edge: inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103+ but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4+ T cells and promote airway tolerance by Khare, Anupriya, Krishnamoorthy, Nandini, Oriss, Timothy B, Fei, Mingjian, Ray, Prabir, Ray, Anuradha

“…Dendritic cell (DC)-T cell interactions that underlie inducible/adaptive regulatory T cell generation and airway tolerance are not well understood. In this…”
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Cutting Edge: Dual Function of PPARγ in CD11c+ Cells Ensures Immune Tolerance in the Airways by Khare, Anupriya, Chakraborty, Krishnendu, Raundhal, Mahesh, Ray, Prabir, Ray, Anuradha

“…The respiratory tract maintains immune homeostasis despite constant provocation by environmental Ags. Failure to induce tolerogenic responses to allergens…”
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Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma by Krishnamoorthy, Nandini, Khare, Anupriya, Oriss, Timothy B, Raundhal, Mahesh, Morse, Christina, Yarlagadda, Manohar, Wenzel, Sally E, Moore, Martin L, Peebles, R Stokes, Ray, Anuradha, Ray, Prabir

“…Recurrent infections with respiratory syncytial virus (RSV) early in life increase susceptibility to asthma. Nandini Krishnamoorthy et al . show that RSV…”
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Dual Function of PPARγ in CD11c+ Cells Ensures Immune Tolerance in the Airways by Khare, Anupriya, Chakraborty, Krishnendu, Raundhal, Mahesh, Ray, Prabir, Ray, Anuradha

“…The respiratory tract maintains immune homeostasis despite constant provocation by environmental antigens. Failure to induce tolerogenic responses to allergens…”
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Regulatory T cells in many flavors control asthma by Ray, A, Khare, A, Krishnamoorthy, N, Qi, Z, Ray, P

“…That regulatory T cells (Tregs) have a crucial role in controlling allergic diseases such as asthma is now undisputed. The cytokines most commonly implicated…”
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STAT1-regulated lung MDSC-like cells produce IL-10 and efferocytose apoptotic neutrophils with relevance in resolution of bacterial pneumonia by Poe, S L, Arora, M, Oriss, T B, Yarlagadda, M, Isse, K, Khare, A, Levy, D E, Lee, J S, Mallampalli, R K, Chan, Y R, Ray, A, Ray, P

“…Bacterial pneumonia remains a significant burden worldwide. Although an inflammatory response in the lung is required to fight the causative agent, persistent…”
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Cutting Edge: MMP-9 inhibits IL-23p19 expression in dendritic cells by targeting membrane stem cell factor affecting lung IL-17 response by Oriss, Timothy B, Krishnamoorthy, Nandini, Raundhal, Mahesh, Morse, Christina, Chakraborty, Krishnendu, Khare, Anupriya, Huff, Rachael, Ray, Prabir, Ray, Anuradha

“…We reported previously that c-kit ligation by membrane-bound stem cell factor (mSCF) boosts IL-6 production in dendritic cells (DCs) and a Th17-immune…”
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Lung MDSC-derived IL-10 in resolution of inflammation during bacterial pneumonia (INM2P.420) by Chakraborty, Krishnendu, Khare, Anupriya, Raundhal, Mahesh, Poe, Stephanie, Morse, Christina, Huff, Rachael, Ray, Anuradha, Ray, Prabir

“…Abstract Bacterial pneumonia remains a significant burden worldwide. Although an inflammatory response in the lung is required to fight against pathogenic…”
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Peroxisome proliferator-activated receptor-gamma expression in dendritic cells determines immune tolerance versus immune activation (HYP6P.256) by Khare, Anupriya, Chakraborty, Krishnendu, Raundhal, Mahesh, Morse, Christina, Ray, Prabir, Ray, Anuradha

“…Abstract Dendritic cells (DCs) play a central role in regulating immune tolerance and activation but the molecular axis within DCs that dictates immune outcome…”
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Comparison of the immunogenicity and safety of Euvichol-Plus with Shanchol in healthy Indian adults and children: an open-label, randomised, multicentre, non-inferiority, parallel-group, phase 3 trial by Shah, Sanket, Nandy, Ranjan Kumar, Sethi, Shaily S., Chavan, Bhakti, Pathak, Sarang, Dutta, Shanta, Rai, Sanjay, Singh, Chandramani, Chayal, Vinod, Patel, Chintan, Kumar, N. Ravi, Chavan, Abhishek T., Chawla, Amit, Singh, Anit, Roy, Anupriya Khare, Singh, Nidhi, Baik, Yeong Ok, Lee, Youngjin, Park, Youngran, Jeong, Kyung Ho, Ahmed, Syed

“…Considering the cholera menace in India and to seek licensure of the oral cholera vaccine (OCV), Euvichol-Plus, we conducted a clinical trial to compare the…”
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High IFN-γ and low SLPI mark severe asthma in mice and humans by Raundhal, Mahesh, Morse, Christina, Khare, Anupriya, Oriss, Timothy B, Milosevic, Jadranka, Trudeau, John, Huff, Rachael, Pilewski, Joseph, Holguin, Fernando, Kolls, Jay, Wenzel, Sally, Ray, Prabir, Ray, Anuradha

“…Severe asthma (SA) is a challenge to control, as patients are not responsive to high doses of systemic corticosteroids (CS). In contrast, mild-moderate asthma…”
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High IFN-[gamma] and low SLPI mark severe asthma in mice and humans by Raundhal, Mahesh, Morse, Christina, Khare, Anupriya, Oriss, Timothy B, Milosevic, Jadranka, Trudeau, John, Huff, Rachael, Pilewski, Joseph, Holguin, Fernando, Kolls, Jay, Wenzel, Sally, Ray, Prabir, Ray, Anuradha

“…Severe asthma (SA) is a challenge to control, as patients are not responsive to high doses of systemic corticosteroids (CS). In contrast, mild-moderate asthma…”
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Inhaled Antigen Upregulates Retinaldehyde Dehydrogenase In Lung CD103+ But Not Plasmacytoid Dendritic Cells To Induce Foxp3 De Novo in CD4+ T cells and Promote Airway Tolerance by Khare, Anupriya, Krishnamoorthy, Nandini, Oriss, Timothy B., Fei, Mingjian, Ray, Prabir, Ray, Anuradha

“…Dendritic cell (DC)-T cell interactions that underlie iTreg generation and airway tolerance are not well understood. Here we show that mice lacking CD11c hi…”
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MMP-9 Inhibits IL-23p19 Expression in Dendritic Cells By Targeting Membrane Stem Cell Factor Affecting Lung IL-17 Response1 by Oriss, Timothy B., Krishnamoorthy, Nandini, Raundhal, Mahesh, Morse, Christina, Chakraborty, Krishnendu, Khare, Anupriya, Huff, Rachael, Ray, Prabir, Ray, Anuradha

“…We previously reported that c-kit ligation by membrane-bound stem cell factor (mSCF) boosts IL-6 production in DCs and a Th17 immune response. However, Th17…”
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