Search Results - "Khara, Basile"

Production of Propane and Other Short-Chain Alkanes by Structure-Based Engineering of Ligand Specificity in Aldehyde-Deformylating Oxygenase by Khara, Basile, Menon, Navya, Levy, Colin, Mansell, David, Das, Debasis, Marsh, E. Neil G., Leys, David, Scrutton, Nigel S.

“…Biocatalytic propane production: structure‐based engineering of aldehyde‐deformylating oxygenase improves specificity for short‐ and medium‐chain‐length…”
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Coupled motions direct electrons along human microsomal P450 Chains by Pudney, Christopher R, Khara, Basile, Johannissen, Linus O, Scrutton, Nigel S

“…Protein domain motion is often implicated in biological electron transfer, but the general significance of motion is not clear. Motion has been implicated in…”
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Nature of the Energy Landscape for Gated Electron Transfer in a Dynamic Redox Protein by Hay, Sam, Brenner, Sibylle, Khara, Basile, Quinn, Anne Marie, Rigby, Stephen E. J, Scrutton, Nigel S

“…Conformational control limits most electron transfer (ET) reactions in biology, but we lack general insight into the extent of conformational space explored,…”
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Ultrafast red light activation of Synechocystis phytochrome Cph1 triggers major structural change to form the Pfr signalling-competent state by Heyes, Derren J, Khara, Basile, Sakuma, Michiyo, Hardman, Samantha J O, O'Cualain, Ronan, Rigby, Stephen E J, Scrutton, Nigel S

“…Phytochromes are dimeric photoreceptors that regulate a range of responses in plants and microorganisms through interconversion of red light-absorbing (Pr) and…”
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New cofactor supports α,β-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition by Payne, Karl A. P., White, Mark D., Fisher, Karl, Khara, Basile, Bailey, Samuel S., Parker, David, Rattray, Nicholas J. W., Trivedi, Drupad K., Goodacre, Royston, Beveridge, Rebecca, Barran, Perdita, Rigby, Stephen E. J., Scrutton, Nigel S., Hay, Sam, Leys, David

“…The Fdc1 protein from Aspergillus niger (which is homologous to the UbiD enzyme) uses a new prenylated flavin cofactor to achieve 1,3-dipolar cycloaddition…”
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Kinetic and spectroscopic probes of motions and catalysis in the cytochrome P450 reductase family of enzymes by Pudney, Christopher R., Heyes, Derren J., Khara, Basile, Hay, Sam, Rigby, Stephen E. J., Scrutton, Nigel S.

“…There is a mounting body of evidence to suggest that enzyme motions are linked to function, although the design of informative experiments aiming to evaluate…”
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New cofactor supports [alpia],[bera]-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition by Payne, Karl A. P, White, Mark D, Fisher, Karl, Khara, Basile, Bailey, Samuel S, Parker, David, Rattray, Nicholas J. W, Trivedi, Drupad K, Goodacre, Royston, Beveridge, Rebecca, Barran, Perdita, Rigby, Stephen E. J, Scrutton, Nigel S, Hay, Sam, Leys, David

“…The bacterial ubiD and ubiX or the homologous fungal fdc1 and pad1 genes have been implicated in the non-oxidative reversible decarboxylation of aromatic…”
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Directed Evolution in the Production of Penicillins and Cephalosporins by Khara, Basile

“…P. chrysogenum acyltransferase (AT) encoded by the penDE gene has three main enzymatic activities.(1) Amidohydrolase activity (IAH) responsible for the…”
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