Circadian rhythms of hemodynamic load on the cardiovascular system in patients with essential hypertension: implication for drug therapy rationale

Circadian rhythm of hemodynamic load by double product (heart rate x systolic blood pressure) was studied in 224 patients with essential hypertension (EH) treated with different antihypertensive drugs for 8-12 weeks and in 23 healthy subjects. The main feature of the rhythm was a marked morning rise...

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Bibliographic Details
Published in:	Klinicheskaia meditsina Vol. 79; no. 3; p. 52
Main Authors:	Komarov, F I, Ol'binskaia, L I, Khapaev, V A
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2001
Subjects:	Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Cerebrovascular Circulation - drug effects Circadian Rhythm - drug effects Female Hemodynamics - drug effects Humans Hypertension - drug therapy Male Middle Aged
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Summary:	Circadian rhythm of hemodynamic load by double product (heart rate x systolic blood pressure) was studied in 224 patients with essential hypertension (EH) treated with different antihypertensive drugs for 8-12 weeks and in 23 healthy subjects. The main feature of the rhythm was a marked morning rise in all the patients including non-dippers and night-peakers without nocturnal blood pressure fall. The examined drugs showed different effects on mean 24-h and morning values of the double product.
ISSN:	0023-2149