Search Results - "Khanolkar, Aaruni"

Elucidating T Cell and B Cell Responses to SARS-CoV-2 in Humans: Gaining Insights into Protective Immunity and Immunopathology by Khanolkar, Aaruni

“…The SARS-CoV-2 pandemic is an unprecedented epochal event on at least two fronts. Firstly, in terms of the rapid spread and the magnitude of the outbreak, and…”
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Mechanisms and modulation of sepsis-induced immune dysfunction in children by Mithal, Leena B., Arshad, Mehreen, Swigart, Lindsey R., Khanolkar, Aaruni, Ahmed, Aisha, Coates, Bria M.

“…Immunologic responses during sepsis vary significantly among patients and evolve over the course of illness. Sepsis has a direct impact on the immune system…”
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Defining the Basal and Immunomodulatory Mediator-Induced Phosphoprotein Signature in Pediatric B Cell Acute Lymphoblastic Leukemia (B-ALL) Diagnostic Samples by Khanolkar, Aaruni, Liu, Guorong, Simpson Schneider, Bridget M

“…It is theorized that dysregulated immune responses to infectious insults contribute to the development of pediatric B-ALL. In this context, our understanding…”
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Clinical Aspects of B Cell Immunodeficiencies: The Past, the Present and the Future by Ahmed, Aisha, Lippner, Elizabeth, Khanolkar, Aaruni

“…B cells and antibodies are indispensable for host immunity. Our understanding of the mechanistic processes that underpin how B cells operate has left an…”
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X-Linked Inhibitor of Apoptosis (XIAP) deficiency presenting as hemophagocytic lymphohistiocytosis triggered by drug allergy by Khojah, Amer, Bukhari, Ameera, Khanolkar, Aaruni, Khojah, Imad, Lang, Abigail

“…X-linked inhibitor of apoptosis (XIAP) deficiency is a primary immunodeficiency associated with recurrent hemophagocytic lymphohistiocytosis (HLH) episodes…”
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Increased percentage of HLA-DR T cells in untreated juvenile dermatomyositis by Khojah, Amer, Schutt, Madeline, Morgan, Gabrielle, Bukhari, Ameera, Bensen, Nicolas, Khanolkar, Aaruni, Pachman, Lauren M.

“…This study investigates HLA-DR expression on activated T cells and serum neopterin levels in Juvenile Dermatomyositis (JDM) children pre- and post-treatment…”
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A case of aberrant CD8 T cell–restricted IL-7 signaling with a Janus kinase 3 defect–associated atypical severe combined immunodeficiency by Khanolkar, Aaruni, Wilks, Jeffrey D., Liu, Guorong, Simpson, Bridget M., Caparelli, Edward A., Kirschmann, Dawn A., Bergerson, Jenna, Fuleihan, Ramsay L.

“…Severe combined immunodeficiency (SCID) disorders compromise lymphocyte numbers and/or function. One subset of SCID typically affects T cell and Natural Killer…”
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Co-Occurring X-Linked Agammaglobulinemia and X-Linked Chronic Granulomatous Disease: Two Isolated Pathogenic Variants in One Patient by Gunderman, Lauren, Brown, Jeffrey, Chaudhury, Sonali, O'Gorman, Maurice, Fuleihan, Ramsay, Khanolkar, Aaruni, Ahmed, Aisha

“…We present a unique and unusual case of a male patient diagnosed with two coexisting and typically unassociated X-linked conditions: he was initially diagnosed…”
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Antigen experience shapes phenotype and function of memory Th1 cells by Khanolkar, Aaruni, Williams, Matthew A, Harty, John T

“…Primary and secondary (boosted) memory CD8 T cells exhibit differences in gene expression, phenotype and function. The impact of repeated antigen stimulations…”
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Toll-Like Receptor 4 Deficiency Increases Disease and Mortality after Mouse Hepatitis Virus Type 1 Infection of Susceptible C3H Mice by KHANOLKAR, Aaruni, HARTWIG, Stacey M, HAAG, Brayton A, MEYERHOLZ, David K, HARTY, John T, VARGA, Steven M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Preservation of lymphocyte functional fitness in perinatally-infected and treated HIV+ pediatric patients displaying sub-optimal viral control by Khanolkar, Aaruni, Muller, William J., Simpson, Bridget M., Cerullo, Jillian, Williams, Ruth, Sowers, Sun Bae, Matthews, Kiana, Mercader, Sara, Hickman, Carole J., D’Aquila, Richard T., Liu, Guorong

“…Background Host–pathogen dynamics associated with HIV infection are quite distinct in children versus adults. We interrogated the functional fitness of the…”
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Protective and Pathologic Roles of the Immune Response to Mouse Hepatitis Virus Type 1: Implications for Severe Acute Respiratory Syndrome by KHANOLKAR, Aaruni, HARTWIG, Stacey M, HAAG, Brayton A, MEYERHOLZ, David K, EPPING, Lecia L, HARING, Jodie S, VARGA, Steven M, HARTY, John T

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Signaling impairments in maternal T cells engrafted in an infant with a novel IL-2 receptor γ mutation by Khanolkar, Aaruni, MBBS, PhD, Wilks, Jeffrey D., BS, Jennings, Lawrence J., MD, PhD, Davies, Jessica L., BS, Zollett, Joshua A., BS, Lott, Loren L., BS, Fullmer, Erin R., BS, Bensen, Nicolas E., BS, Carlson-Leuer, Katrin M., PhD, Tse, William T., MD, PhD, Fuleihan, Ramsay L., MD

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Comparison of seven heterophile antibody assays for laboratory diagnosis of infectious mononucleosis in pediatric patients by Wei, Sharon, Huang, Wei, Farah, Mohamed, Khanolkar, Aaruni, Zheng, Xiaotian

“…Heterophile antibody assays have been used to aid the diagnosis of infectious mononucleosis caused by the Epstein‐Barr virus. Seven commercially available…”
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Chronic Granulomatous Disease: A Large, Single-center US Experience by Bortoletto, Pietro, Lyman, Kyle, Camacho, Andres, Fricchione, Marielle, Khanolkar, Aaruni, Katz, Ben Z

“…BACKGROUND:Chronic granulomatous disease (CGD) is an uncommon primary immunodeficiency that can be inherited in an X-linked (XL) or an autosomal recessive (AR)…”
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An Unexpected Diagnosis of MAGT1 Deficiency in a Patient with CVID-like Features, Molluscum Contagiosum and Atopy by Schutt, Madeline, Gunderman, Lauren, Lippner, Elizabeth, Ahmed, Aisha, Khanolkar, Aaruni, Khojah, Amer

“…A 6-year-old boy presented to the immunology clinic with recurrent infections. He started to have recurrent otitis media at the age of 18 months. He also had…”
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Persistent CD8 T cell restricted aberrant IL-7 signaling in an atypical (T-B+NK+) SCID patient with compound heterozygous JAK3 mutations by Khanolkar, Aaruni, Wilks, Jeffrey, Liu, Guorong, Simpson, Bridget, Caparelli, Edward, Kirschmann, Dawn, Bergerson, Jenna, Fuleihan, Ramsay

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Relapse of large B‐cell lymphoma with IRF4 rearrangement associated with SLAM‐associated protein deficiency by Elhodaky, Mostafa, Gunderman, Lauren M., Bachula, Mateusz, Liu, Guorong, Reilly, Paige, Schmidt, Mary L., Frederiksen, John Karl, Lu, Xinyan, Jennings, Lawrence, Rossoff, Jenna, Khanolkar, Aaruni, Gong, Shunyou

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Cytokine-free directed differentiation of human pluripotent stem cells efficiently produces hemogenic endothelium with lymphoid potential by Galat, Yekaterina, Dambaeva, Svetlana, Elcheva, Irina, Khanolkar, Aaruni, Beaman, Kenneth, Iannaccone, Philip M, Galat, Vasiliy

“…The robust generation of human hematopoietic progenitor cells from induced or embryonic pluripotent stem cells would be beneficial for multiple areas of…”
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CD4 T cell–restricted IL-2 signaling defect in a patient with a novel IFNGR1 deficiency by Khanolkar, Aaruni, Kirschmann, Dawn A., Caparelli, Edward A., Wilks, Jeffrey D., Cerullo, Jillian M., Bergerson, Jenna R.E., Jennings, Lawrence J., Fuleihan, Ramsay L.

“…The clinical findings coupled with a normal dihydrorhodamine test result (Table I), a negative family history of tuberculosis, or frequent and serious…”
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