Search Results - "Khandazhinskaya, A. L."

Cytotoxicity Studies of 5-Arylaminouracil Derivatives by Kezin, V. A., Matyugina, E. S., Surzhikov, S. A., Novikov, M. S., Maslova, A. A., Karpenko, I. L., Ivanov, A. V., Kochetkov, S. N., Khandazhinskaya, A. L.

“…We have previously shown that 5-arylaminouracil derivatives can inhibit HIV-1, herpesviruses, mycobacteria, and other pathogens through various mechanisms. The…”
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Interaction of DNA Methyltransferase Dnmt3a with Phosphorus Analogs of S-Adenosylmethionine and S-Adenosylhomocysteine by Filonov, V. L., Khomutov, M. A., Sergeev, A. V., Khandazhinskaya, A. L., Kochetkov, S. N., Gromova, E. S., Khomutov, A. R.

“…Enzymatic methyltransferase reactions are of crucial importance for cell metabolism. S -Adenosyl- L -methionine (AdoMet) is a main donor of the methyl group…”
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1,2,4-Triazoloazine derivatives as a new type of herpes simplex virus inhibitors by Deev, S.L., Yasko, M.V., Karpenko, I.L., Korovina, A.N., Khandazhinskaya, A.L., Andronova, V.L., Galegov, G.A., Shestakova, T.S., Ulomskii, E.N., Rusinov, V.L., Chupakhin, O.N., Kukhanova, M.K.

“…Structure of synthesized compounds. A new class of inhibitors of herpes simplex virus replication was found. The compounds under study are derived from…”
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Synthesis of 1-[ω-(Bromophenoxy)alkyl]-3-naphthalenylmethyl Derivatives of Uracil and Their Analogues As Probable Inhibitors of Human Cytomegalovirus Replication by Paramonova, M. P., Gureeva, E. S., Ozerov, A. A., Snoeck, R., Andrei, G., Aleksandrov, D. A., Khandazhinskaya, A. L., Novikov, M. S., Kochetkov, S. N.

“…The synthesis of a new series of 1-[ω-(bromophenoxy)alkyl]-uracil derivatives containing in position 3 naphthalen-1-yl-, naphthalen-2-yl-,…”
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New Analogues of Uridine as Possible Anti-Viral Agents Specific to SARS-CoV-2 by Maslova, A. A., Matyugina, E. C., Shustova, E. Yu, Volok, V. P., Kozlovskaya, L. I., Kochetkov, S. N., Khandazhinskaya, A. L.

“…The development of specific drugs against SARS-CoV-2 infection is a major challenge facing global science and healthcare. Despite numerous attempts, there are…”
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Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors by Mukovnya, A. V., Tunitskaya, V. L., Khandazhinskaya, A. L., Golubeva, N. A., Zakirova, N. F., Ivanov, A. V., Kukhanova, M. K., Kochetkov, S. N.

“…A method has been developed for obtaining a full-length protein NS3 of hepatitis C virus with the yield of 6.5 mg/liter of cell culture, and conditions for…”
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Evaluation of the Antiviral Potential of Modified Heterocyclic Base and 5'-Norcarbocyclic Nucleoside Analogs Against SARS-CoV-2 by Matyugina, E S, Novikov, M S, Kozlovskaya, L I, Volok, V P, Shustova, E Y, Ishmukhametov, A A, Kochetkov, S N, Khandazhinskaya, A L

“…The pandemic caused by the novel betacoronavirus SARS-CoV-2 has already claimed more than 3.5 million lives. Despite the development and use of anti-COVID-19…”
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Synthesis and antiviral properties of 1-substituted 3-[ω-(4-oxoquinazolin-4(3h)-yl)alkyl]uracil derivatives by Paramonova, Maria P., Khandazhinskaya, Anastasia L., Ozerov, Alexander A., Kochetkov, Sergey N., Snoeck, Robert, Andrei, Graciela, Novikov, Mikhail S.

“…А series of uracil derivatives containing a 4-oxoquinazoline fragment bound to the nitrogen atom N3 of the pyrimidine ring by a short methylene bridge was…”
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5′-Norcarbocyclic nucleoside analogs by Matyugina, E. S., Khandazhinskaya, A. L.

“…The present review briefly outlines main methods for the synthesis of 5′-norcarbocyclic nucleoside analogs and the biological activity spectrum of these…”
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ANTI-HIV ACTIVITY OF NOVEL PHOSPHONATE DERIVATIVES OF AZT, d4T, AND ddA by Pokrovsky, A. G., Pronayeva, T. R., Fedyuk, N. V., Shirokova, E. A., Khandazhinskaya, A. L., Tarusova, N. B., Karpenko, I. L., Krayevsky, A. A.

“…Anti-HIV activity and cytotoxicity were tested for novel phosphonate derivatives of AZT, d4T and ddA. For d4T phosphonate derivatives the most active was…”
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2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors by Babkov, D A, Paramonova, M P, Ozerov, A A, Khandazhinskaya, A L, Snoeck, R, Andrei, G, Novikov, M S

“…A series of novel uracil derivatives, bearing N-(4-phenoxyphenyl)acetamide moiety at N3 of a pyrimidine ring, has been synthesized. Their antiviral activity…”
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5-Arylaminouracil Derivatives as Potential Dual-Action Agents by Matyugina, E S, Novikov, M S, Babkov, D A, Valuev-Elliston, V T, Vanpouille, C, Zicari, S, Corona, A, Tramontano, E, Margolis, L B, Khandazhinskaya, A L, Kochetkov, S N

“…Several 5-aminouracil derivatives that have previously been shown to inhibit Mycobacterium tuberculosis growth at concentrations of 5-40 μg/mL are demonstrated…”
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Carbocyclic analogues of inosine-5'-monophosphate: synthesis and biological activity by Matyugina, E S, Andreevskaya, S N, Smirnova, T G, Khandazhinskaya, A L

“…9-(4'-Phosphonomethoxy-2'-cyclopenten-1'-yl)hypoxanthine and 9-(4'-phosphonomethoxy-2',3'-dihydroxycyclopenten-1'-yl)hypoxanthine were synthesized as isosteric…”
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Synthesis and antiviral evaluation against the Vaccinia virus of new N ₁-oxide analogs of 5′-noraristeromycin by Matyugina, E. S, Seley-Radtke, K. L, Andronova, V. L, Galegov, G. A, Kochetkov, S. N, Khandazhinskaya, A. L

“…New N ₁-benzyl esters of N ₁-oxide analogues of 5′-noraristeromycin were synthesized and tested as potential inhibitors of S-adenosyl-L-homocysteine hydrolase…”
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TELOMERASE-DEPENDENT REACTIVATION OF DNA SYNTHESIS IN MACROPHAGES IMPLIES ALTERATION OF TELOMERES by Yegorov, Y.E., Kazimirchuk, E.V., Terekhov, S.M., Karachentsev, D.N., Shirokova, E.A., Khandazhinskaya, A.L., Meshcheryakova, J.A., Corey, D.R., Zelenin, A.V.

“…In previous work we demonstrated that various types of cultured cells with a limited life span could not reactivate DNA synthesis in the nuclei of mouse…”
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P-(Alkyl)-Nucleoside 5′-Hydrogenphosphonates as Depot Forms of Antiviral Nucleotide Analogues by Khandazhinskaya, A. L., Shirokova, E. A., Karpenko, I. L., Zakirova, N. F., Tarussova, N. B., Krayevsky, A. A.

“…P-(Alkyl)esters of AZT 5′-hydrogenphosphonate were synthesized and their stabilities in the phosphate buffer and human serum were evaluated. The esters bearing…”
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MODIFIED DINUCLEOSIDE TETRAPHOSPHONATES, NEW POTENTIAL INHIBITORS OF HIV REVERSE TRANSCRIPTASE by Shirokova, E. A., Khandazhinskaya, A. L., Skoblov, Yu. S., Goryunova, L. Ye, Beabealashvilli, R. S., Krayevsky, A. A.

“…New γ-substituted analogues of dNTP were synthesized and their enzymatic stability and antiviral properties were evaluated…”
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AZT 5'-Phosphonates: Achievements and Trends in the Treatment and Prevention of HIV Infection by Khandazhinskaya, Capital A Cyrillic L, Shirokova, E A

“…Despite the numerous drawbacks, 3'-azido-3'-deoxythymidine (AZT, Zidovudine, Retrovir) remains one of the key drugs used in the treatment and prevention of HIV…”
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Synthesis and antiviral evaluation against the Vaccinia virus of new N1-oxide analogs of 5′-noraristeromycin by Matyugina, E. S., Seley-Radtke, K. L., Andronova, V. L., Galegov, G. A., Kochetkov, S. N., Khandazhinskaya, A. L.

“…New N 1 -benzyl esters of N 1 -oxide analogues of 5′-noraristeromycin were synthesized and tested as potential inhibitors of S -adenosyl- L -homocysteine…”
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Aryl-Containing Esters Of Triphosphoric Acid As Substrates Of Terminal Deoxynucleotidyl Transferase by Khandazhinskaya, A. L., Matyugina, E. S., Alexandrova, L. A., Shirokova, E. A., Kukhanova, M. K., Jasko, M. V.

“…A new group of terminal deoxynucleotidyltransferase (TDT) substrates, namely, non-nucleoside triphosphates (NNTP) bearing 5-substituted 2,4-dinitrophenyl…”
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