Search Results - "Khanal, Prem"

The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1 by Janse van Rensburg, Helena J, Azad, Taha, Ling, Min, Hao, Yawei, Snetsinger, Brooke, Khanal, Prem, Minassian, Lori M, Graham, Charles H, Rauh, Michael J, Yang, Xiaolong

“…The Hippo pathway component WW domain-containing transcription regulator 1 (TAZ) is a transcriptional coactivator and an oncogene in breast and lung cancer…”
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Identification of Prolyl isomerase Pin1 as a novel positive regulator of YAP/TAZ in breast cancer cells by Khanal, Prem, Yeung, Benjamin, Zhao, Yulei, Yang, Xiaolong

“…The Hippo signalling pathway plays very important roles in tumorigenesis, metastasis, organ size control, and drug resistance. Although, it has been shown that…”
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A gain-of-functional screen identifies the Hippo pathway as a central mediator of receptor tyrosine kinases during tumorigenesis by Azad, Taha, Nouri, Kazem, Janse van Rensburg, Helena J., Maritan, Sarah M., Wu, Liqing, Hao, Yawei, Montminy, Tess, Yu, Jihang, Khanal, Prem, Mulligan, Lois M., Yang, Xiaolong

“…The Hippo pathway has emerged as a key signaling pathway that regulates various biological functions. Dysregulation of the Hippo pathway has been implicated in…”
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Cysteine residues are essential for dimerization of Hippo pathway components YAP2L and TAZ by Khanal, Prem, Jia, Zongchao, Yang, Xiaolong

“…Hippo signalling pathway is an emerging signalling pathway that plays important roles in organ size control, tumorigenesis, metastasis, stress response,…”
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YAP-Induced Resistance of Cancer Cells to Antitubulin Drugs Is Modulated by a Hippo-Independent Pathway by YULEI ZHAO, KHANAL, Prem, SAVAGE, Paul, SHE, Yi-Min, CYR, Terry D, XIAOLONG YANG

“…Although antitubulin drugs are used widely to treat human cancer, many patients display intrinsic or acquired drug resistance that imposes major obstacles to…”
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Author Correction: A one-step tRNA-CRISPR system for genome-wide genetic interaction mapping in mammalian cells by Zhao, Yulei, Tyrishkin, Kathrin, Sjaarda, Calvin, Khanal, Prem, Stafford, Jeff, Rauh, Michael, Liu, Xudong, Babak, Tomas, Yang, Xiaolong

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Identification of Cdk1-LATS-Pin1 as a Novel Signaling Axis in Anti-tubulin Drug Response of Cancer Cells by Yeung, Benjamin, Khanal, Prem, Mehta, Virja, Trinkle-Mulcahy, Laura, Yang, Xiaolong

“…The Hippo pathway is a signaling cascade that plays important roles in organ size control, tumorigenesis, metastasis, stress response, stem cell…”
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Biochemical Correction of GM2 Ganglioside Accumulation in AB-Variant GM2 Gangliosidosis by Deschenes, Natalie M, Cheng, Camilyn, Ryckman, Alex E, Quinville, Brianna M, Khanal, Prem, Mitchell, Melissa, Chen, Zhilin, Sangrar, Waheed, Gray, Steven J, Walia, Jagdeep S

“…GM2 gangliosidosis is a group of genetic disorders that result in the accumulation of GM2 ganglioside (GM2) in brain cells, leading to progressive central…”
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Characterization of a phenotypically severe animal model for human AB-Variant GM2 gangliosidosis by Deschenes, Natalie M, Cheng, Camilyn, Khanal, Prem, Quinville, Brianna M, Ryckman, Alex E, Mitchell, Melissa, Pshezhetsky, Alexey V, Walia, Jagdeep S

“…AB-Variant GM2 gangliosidosis (ABGM2) is a rare and lethal genetic disorder caused by mutations in the gene that lead to fatal accumulation of GM2 gangliosides…”
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COT phosphorylates prolyl-isomerase Pin1 to promote tumorigenesis in breast cancer by Kim, Garam, Khanal, Prem, Kim, Jin Young, Yun, Hyo-Jeong, Lim, Sung-Chul, Shim, Jung-Hyun, Choi, Hong Seok

“…Pin1, a conserved eukaryotic Peptidyl‐prolyl cis/trans isomerase, has profound effects on numerous key‐signaling molecules, and its deregulation contributes to…”
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The Prolyl Isomerase Pin1 Induces LC-3 Expression and Mediates Tamoxifen Resistance in Breast Cancer by Namgoong, Gwang Mo, Khanal, Prem, Cho, Hae-Guk, Lim, Sung-Chul, Oh, Yoon Kyeong, Kang, Bong Seok, Shim, Jeong-Hyun, Yoo, Jin-Cheol, Choi, Hong Seok

“…Endocrine therapies, which inhibit estrogen receptor signaling, are the most common and effective treatments for estrogen receptorα-positive breast cancer…”
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Inhibitory Effects of a New 1H-Pyrrolo[3,2-c]pyridine Derivative, KIST101029, on Activator Protein-1 Activity and Neoplastic Cell Transformation Induced by Insulin-Like Growth Factor-1 by Yun, Hyo Jeong, Kim, Garam, Khanal, Prem, Kim, Karam, Oh, Chang-Hyun, Choi, Hoo-Kyun, Sohn, Honglae, Choi, Hong Seok

“…Diarylureas and diarylamides derivatives are reported to have antitumor activity. Encouraged by the interesting antiproliferative activity of diarylurea and…”
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Aglycon of Rhizochalin from the Rhizochalina incrustata Induces Apoptosis via Activation of AMP-Activated Protein Kinase in HT-29 Colon Cancer Cells by Khanal, Prem, Kang, Bong Seok, Yun, Hyo Jeong, Cho, Hae-Guk, Makarieva, Tatyana Nikolaevna, Choi, Hong Seok

“…Rhizochalin is a two-headed sphingolipid-like compound isolated from the sponge Rhizochalina incrustata. It has been reported that rhizocalin and its derivates…”
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5′-Nitro-indirubinoxime inhibits epidermal growth factor- and phorbol ester-induced AP-1 activity and cell transformation through inhibition of phosphorylation of Pin1 by Khanal, Prem, Choi, Hoo-Kyun, Namgoong, Gwang Mo, Ahn, Sang-Gun, Yoon, Jung-Hoon, Sohn, Honglae, Choi, Hong Seok

“…5′‐Nitro‐indirubinoxime (5′‐NIO), a derivative of indirubin, exhibits anti‐cancer activity in a variety of human cancer cells. However, the underlying…”
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A kinome‐wide screen using a NanoLuc LATS luminescent biosensor identifies ALK as a novel regulator of the Hippo pathway in tumorigenesis and immune evasion by Nouri, Kazem, Azad, Taha, Lightbody, Elizabeth, Khanal, Prem, Nicol, Christopher J., Yang, Xiaolong

“…The Hippo pathway is an emerging signaling pathway that plays important roles in organ size control, tissue homeostasis, tumorigenesis, metastasis, drug…”
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Abstract 4422: A Hippo-independent pathway modulates YAP-induced resistance of cancer cells to antitubulin drugs by Zhao, Yulei, Khanal, Prem, Yang, Xiaolong

“…Abstract Antitubulin drugs have been widely used for the treatment of various human cancers including breast and lung cancer, etc. Although these drugs are…”
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A one-step tRNA-CRISPR system for genome-wide genetic interaction mapping in mammalian cells by Zhao, Yulei, Tyrishkin, Kathrin, Sjaarda, Calvin, Khanal, Prem, Stafford, Jeff, Rauh, Michael, Liu, Xudong, Babak, Tomas, Yang, Xiaolong

“…Mapping genetic interactions in mammalian cells is limited due to technical obstacles. Here we describe a method called TCGI (tRNA-CRISPR for genetic…”
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Pin1 is overexpressed in tamoxifen‐resistant breast cancer and facilitates ubiquitin‐mediated degradation of cyclin dependent kinase 10 by Choi, Hong Seok, Khanal, Prem

“…Abstract only The aim of this study was to elucidate the mechanisms by which downregulation of CDK10 expression confers resistance to tamoxifen in breast…”
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Abstract 5434: Screen for immune-related transcriptional targets of the Hippo pathway in human breast cancer cells by Rensburg, Helena J. Janse van, Azad, Taha, Ling, Min, Hao, Yawei, Minassian, Lori M., Snetsinger, Brooke, Khanal, Prem, Rauh, Michael J., Graham, Charles H., Yang, Xiaolong

“…Abstract The Hippo signaling pathway has recently emerged as a cellular network that is dysregulated in cancer. In breast cancer cells, aberrant activation of…”
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Frugal innovation and digital effectuation for development: the case of Lucia by Khanal, Prem Bhushan, Aubert, Benoit A., Bernard, Jean-Grégoire, Narasimhamurthy, Ravikumar, Dé, Rahul

“…This paper illustrates how the lens of effectuation and frugal innovation can be employed to understand digital entrepreneurial practices in development…”
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