Search Results - "Khanal, Ohnmar"

Developments and opportunities in continuous biopharmaceutical manufacturing by Khanal, Ohnmar, Lenhoff, Abraham M.

“…Today's biologics manufacturing practices incur high costs to the drug makers, which can contribute to high prices for patients. Timely investment in the…”
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Estimating and leveraging protein diffusion on ion-exchange resin surfaces by Khanal, Ohnmar, Kumar, Vijesh, Schlegel, Fabrice, Lenhoff, Abraham M.

“…Protein mobility at solid–liquid interfaces can affect the performance of applications such as bioseparations and biosensors by facilitating reorganization of…”
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Adeno-associated viral capsid stability on anion exchange chromatography column and its impact on empty and full capsid separation by Khanal, Ohnmar, Kumar, Vijesh, Jin, Mi

“…Recombinant adeno-associated viral vector (rAAV) mediated gene therapy is gaining traction in treating genetic disorders. Current rAAV production systems yield…”
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Mathematical modeling and process analytical technology for continuous chromatography of biopharmaceutical products by Khanal, Ohnmar

“…Chromatography is a widely used separation method that is inherently a batch operation. However, the demand for higher productivity and lower cost and labor…”
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Modeling the Impact of Holdup Volume from Chromatographic Workstations on Ion-Exchange Chromatography by Kumar, Vijesh, Khanal, Ohnmar, Jin, Mi

“…Chromatographic workstations can significantly impact column chromatography performance by altering the peak shape and retention time. Inclusion of system…”
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Displacement to separate host‐cell proteins and aggregates in cation‐exchange chromatography of monoclonal antibodies by Khanal, Ohnmar, Kumar, Vijesh, Lenhoff, Abraham M.

“…An efficient and consistent method of monoclonal antibody (mAb) purification can improve process productivity and product consistency. Although protein A…”
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Multi-column displacement chromatography for separation of charge variants of monoclonal antibodies by Khanal, Ohnmar, Kumar, Vijesh, Westerberg, Karin, Schlegel, Fabrice, Lenhoff, Abraham M.

“…•Charge variants of a mAb were enriched via displacement chromatography.•Continuous processing along with displacement was used to increase yield.•Effective…”
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Contributions of depth filter components to protein adsorption in bioprocessing by Khanal, Ohnmar, Singh, Nripen, Traylor, Steven J., Xu, Xuankuo, Ghose, Sanchayita, Li, Zheng J., Lenhoff, Abraham M.

“…Depth filtration is widely used in downstream bioprocessing to remove particulate contaminants via depth straining and is therefore applied to harvest…”
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DNA retention on depth filters by Khanal, Ohnmar, Xu, Xuankuo, Singh, Nripen, Traylor, Steven J., Huang, Chao, Ghose, Sanchayita, Li, Zheng Jian, Lenhoff, Abraham M.

“…Depth filtration is a commonly-used bioprocessing unit operation for harvest clarification that reduces the levels of process- and product-related impurities…”
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Characterizing and Leveraging Protein-Surface Interactions and Protein Transport for Separations by Khanal, Ohnmar

“…Purification is the current bottleneck in the production of biologics, accounting for well over half of the total manufacturing cost. Purification productivity…”
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Contributions of Depth Filter Components to Protein Adsorption in Protein Bioprocessing by Khanal, Ohnmar, Singh, Nripen, Traylor, Steven J, Xu, Xuankuo, Ghose, Sanchayita, Li, Zheng Jian, Lenhoff, Abraham M

“…Depth filtration is widely used in downstream bioprocessing to remove particulate contaminants via depth straining and is therefore applied to harvest…”
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