Search Results - "Khanal, Dipesh"

High-fidelity probing of the structure and heterogeneity of extracellular vesicles by resonance-enhanced atomic force microscopy infrared spectroscopy by Kim, Sally Yunsun, Khanal, Dipesh, Kalionis, Bill, Chrzanowski, Wojciech

“…Extracellular vesicles (EVs) are highly specialized nanoscale assemblies that deliver complex biological cargos to mediate intercellular communication. EVs are…”
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Smart multifunctional drug delivery towards anticancer therapy harmonized in mesoporous nanoparticles by Baek, Seonmi, Singh, Rajendra K, Khanal, Dipesh, Patel, Kapil D, Lee, Eun-Jung, Leong, Kam W, Chrzanowski, Wojciech, Kim, Hae-Won

“…Nanomedicine seeks to apply nanoscale materials for the therapy and diagnosis of diseased and damaged tissues. Recent advances in nanotechnology have made a…”
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Raman spectroscopic evaluation of crystallinity, chemical composition and stability of pharmaceutical powder aerosols by Khanal, Dipesh, Ke, Wei-Ren, Chan, Hak-Kim

“…[Display omitted] Raman spectroscopy was used to evaluate the effects of temperature and humidity on the physicochemical stability of inhalable spray-dried…”
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Biospectroscopy of Nanodiamond-Induced Alterations in Conformation of Intra- and Extracellular Proteins: A Nanoscale IR Study by Khanal, Dipesh, Kondyurin, Alexey, Hau, Herman, Knowles, Jonathan C., Levinson, Olga, Ramzan, Iqbal, Fu, Dong, Marcott, Curtis, Chrzanowski, Wojciech

“…The toxicity of nanomaterials raises major concerns because of the impact that nanomaterials may have on health, which remains poorly understood. We need to…”
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Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host Interaction by Pinget, Gabriela, Tan, Jian, Janac, Bartlomiej, Kaakoush, Nadeem O, Angelatos, Alexandra Sophie, O'Sullivan, John, Koay, Yen Chin, Sierro, Frederic, Davis, Joel, Divakarla, Shiva Kamini, Khanal, Dipesh, Moore, Robert J, Stanley, Dragana, Chrzanowski, Wojciech, Macia, Laurence

“…The interaction between gut microbiota and host plays a central role in health. Dysbiosis, detrimental changes in gut microbiota and inflammation have been…”
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Inhalable bacteriophage powders: Glass transition temperature and bioactivity stabilization by Chang, Rachel Yoon Kyung, Kwok, Philip Chi Lip, Khanal, Dipesh, Morales, Sandra, Kutter, Elizabeth, Li, Jian, Chan, Hak‐Kim

“…Recent heightened interest in inhaled bacteriophage (phage) therapy for combating antibacterial resistance in pulmonary infections has led to the development…”
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Corrigendum: Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host Interaction by Pinget, Gabriela, Tan, Jian, Janac, Bartlomiej, Kaakoush, Nadeem O, Angelatos, Alexandra Sophie, O'Sullivan, John, Koay, Yen Chin, Sierro, Frederic, Davis, Joel, Divakarla, Shiva Kamini, Khanal, Dipesh, Moore, Robert J, Stanley, Dragana, Chrzanowski, Wojciech, Macia, Laurence

“…[This corrects the article DOI: 10.3389/fnut.2019.00057.]…”
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Dry powder pharmaceutical biologics for inhalation therapy by Chang, Rachel Yoon Kyung, Chow, Michael Y.T., Khanal, Dipesh, Chen, Donghao, Chan, Hak-Kim

“…[Display omitted] Therapeutic biologics such as genes, peptides, proteins, virus and cells provide clinical benefits and are becoming increasingly important…”
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O-PTIR spectroscopy for characterizing active pharmaceutical ingredient specific particle size distributions of nasal spray suspension products by Khanal, Dipesh, Cao, Yue, Tai, Waiting, Kim Chan, Hak

“…[Display omitted] Evaluation of the particle size distribution (PSD) of active pharmaceutical ingredients (APIs) in nasal suspension products is challenging…”
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Enteric-coated bacteriophage tablets for oral administration against gastrointestinal infections by Khanal, Dipesh, Chang, Rachel Yoon Kyung, Hick, Christopher, Morales, Sandra, Chan, Hak-Kim

“…[Display omitted] Intestinal Pseudomonas aeruginosa is highly problematic in immunocompromised patients such as those in intensive care units in hospitals…”
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Applications of AFM-IR for drug delivery vector characterization: infrared, thermal, and mechanical characterization at the nanoscale by Zhang, Jing, Khanal, Dipesh, Banaszak Holl, Mark M.

“…[Display omitted] The development of effective drug delivery systems requires in-depth characterization of the micro- or nanostructure of the material vectors…”
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Ciprofloxacin nanocrystals liposomal powders for controlled drug release via inhalation by Khatib, Isra, Khanal, Dipesh, Ruan, Juanfang, Cipolla, David, Dayton, Francis, Blanchard, James D., Chan, Hak-Kim

“…[Display omitted] This study was conducted to evaluate the feasibility of developing inhalable dry powders of liposomal encapsulated ciprofloxacin nanocrystals…”
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High Resolution Nanoscale Probing of Bacteriophages in an Inhalable Dry Powder Formulation for Pulmonary Infections by Khanal, Dipesh, Chang, Rachel Yoon Kyung, Morales, Sandra, Chan, Hak-Kim, Chrzanowski, Wojciech

“…Use of powder phage formulations for the treatment of multiple-drug-resistant pulmonary infections is gaining attention. To achieve therapeutic benefits, it is…”
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Bulk to Nanometer-Scale Infrared Spectroscopy of Pharmaceutical Dry Powder Aerosols by Khanal, Dipesh, Zhang, Jing, Ke, Wei-Ren, Banaszak Holl, Mark M, Chan, Hak-Kim

“…Solid state chemical analysis of pharmaceutical inhalation aerosols at the individual particle level has been an analytical challenge. These particles can…”
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Nanoscale colocalized thermal and chemical mapping of pharmaceutical powder aerosols by Zhang, Jing, Khanal, Dipesh, Chan, Hak-Kim, Banaszak Holl, Mark M.

“…[Display omitted] Inhalation of pharmaceutical aerosol formulations is widely used to treat respiratory diseases. Spatially resolved thermal characterization…”
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TiO2 Nanoparticles Alter the Expression of Peroxiredoxin Antioxidant Genes by Runa, Sabiha, Khanal, Dipesh, Kemp, Melissa L, Payne, Christine K

“…Titanium dioxide (TiO2) nanoparticles are used industrially and commercially at increasingly high levels. While toxicity is addressed prior to use, it is also…”
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Optical photothermal infrared spectroscopy for nanochemical analysis of pharmaceutical dry powder aerosols by Khanal, Dipesh, Kim, Jinhee, Zhang, Jing, Ke, Wei-Ren, Holl, Mark M. Banaszak, Chan, Hak Kim

“…Graphical representation of the steps involved in the preparation and chemical characterization of spray-dried dry powder inhalation (DPI) aerosol particles of…”
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Distinct Influence of Saturated Fatty Acids on Malignant and Nonmalignant Human Lung Epithelial Cells by Reczyńska, Katarzyna, Khanal, Dipesh, Pielichowska, Kinga, Pamuła, Elżbieta, Chrzanowski, Wojciech

“…The impact of saturated fatty acids (FA) on viability and properties of malignant and nonmalignant cells has not been studied in detail so far. The present…”
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Nanoscale Probing of Liposome Encapsulating Drug Nanocrystal Using Atomic Force Microscopy-Infrared Spectroscopy by Khanal, Dipesh, Khatib, Isra, Ruan, Juanfang, Cipolla, David, Dayton, Francis, Blanchard, James D, Chan, Hak-Kim, Chrzanowski, Wojciech

“…Use of liposomes encapsulating drug nanocrystals for the treatment of diseases like cancer and pulmonary infections is gaining attention. The potential…”
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Co-spray dried hydrophobic drug formulations with crystalline lactose for inhalation aerosol delivery by Ke, Wei-Ren, Kwok, Philip Chi Lip, Khanal, Dipesh, Chang, Rachel Yoon Kyung, Chan, Hak-Kim

“…[Display omitted] Spray drying is a rapid method for converting a liquid feed into dried particles for inhalation aerosols. Lactose is a major inhalation…”
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