Physicochemical Evaluation of Diploknema butyracea Seed Extract and Formulation of Ketoconazole Ointment by Using the Fat as a Base

Physicochemical Evaluation of Diploknema butyracea Seed Extract and Formulation of Ketoconazole Ointment by Using the Fat as a Base

The fat obtained from the ripened seeds of Diploknema butyracea is widely used as a vegetable oil in rural areas of Nepal. This study was aimed for the physicochemical evaluation (acid value, iodine value, saponification value, peroxide value, ester value, pH, and liquefaction point) of the Diplokne...

Full description

Saved in:
Bibliographic Details
Published in:Journal of food quality Vol. 2021; pp. 1 - 11
Main Authors: Pandey, Jitendra, Khanal, Bimal, Bhandari, Jhabilal, Bashyal, Rishav, Pandey, Asmita, Mikrani, Asgar Ali, Aryal, Pramod, Bhandari, Ravin
Format: Journal Article
Language:English
Published: Cairo Hindawi 2021
John Wiley & Sons, Inc
Hindawi Limited
Hindawi-Wiley
Subjects:
Analysis
Antifungal agents
Butter
Drug delivery systems
Food quality
Health products industry
Iodine
Ketoconazole
Laboratories
Liquefaction
Liquid chromatography
Minority & ethnic groups
Pharmaceuticals
Phenolphthalein
Physicochemical properties
Polyethylene glycol
Potash
Potassium
Rural areas
Seeds
Skin
Vegetable oils
South Africa
Nepal
India
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The fat obtained from the ripened seeds of Diploknema butyracea is widely used as a vegetable oil in rural areas of Nepal. This study was aimed for the physicochemical evaluation (acid value, iodine value, saponification value, peroxide value, ester value, pH, and liquefaction point) of the Diploknema butyracea seed extract (chyuri fat) and the formulation of 2% w/w ketoconazole ointment by using it as a base. All the physicochemical parameters were determined quantitatively by using the method of Indian Pharmacopoeia (IP), volume-I. By fusion method, 3 different formulations F-A, F-B, and F-C were prepared, in which different proportions of chyuri fat, polyethylene glycol 6000 (PEG 600), Tween 80, and propylene glycol were used as an ointment base. Various quality parameters such as spreadability, extrudability, viscosity, smoothness, pH, average fill weight, assay, content uniformity, accelerated stability, and drug release profiles were determined. HPLC was used for the determination of ketoconazole content in the ointment formulations. Physicochemical evaluation of the chyuri fat ensured its suitability for industrial purpose. The active ingredient release profile of formulations F-A (87.71%), F-B (88.89%), and F-C (91.09%) after 5 hours were within acceptable range along with other parameters. Assay of the formulations F-A, F-B, and F-C were reported to be 103.01, 107.9, and 102.45%, respectively. Overall, evaluation of the formulation F-A, prepared by using chyrui fat only, gave satisfactory results and most of the parameters were statistically similar (p>0.05) to the F-B and F-C formulated by incorporating a certain proportion of synthetic base. Thus it can be concluded that chyuri fat can be the best alternative to replace the expensive synthetic base.
ISSN:0146-9428
1745-4557
DOI:10.1155/2021/6612135