Polymorphism of glutathione S-transferases as genetic risk factors for the development of complications in type 2 diabetes mellitus

Polymorphism of glutathione S-transferases as genetic risk factors for the development of complications in type 2 diabetes mellitus

Abstract Background Diabetes is characterized by chronic hyperglycemia that produces dysregulation of cellular metabolism and result in excess free radical production and oxidative stress. Glutathione S-transferases (GSTs) are a family of multifunctional enzymes that work as antioxidants. Therefore,...

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Published in:Journal of critical care Vol. 23; no. 3; pp. 444 - 448
Main Authors: Hossaini, Aysheh M, Zamrroni, Israa M, Kashem, Reem A, Khan, Zoiya F.M
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-09-2008
Elsevier Limited
Subjects:
Abdomen
Adult
Antioxidants
Blood Glucose - analysis
Cardiovascular disease
Confidence intervals
Critical Care
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - genetics
Electrophoresis, Agar Gel
Exercise
Family medical history
Female
Free radicals
Genes
Genotype & phenotype
Glutathione Transferase - genetics
GSTM1
GSTT1
Health risk assessment
Humans
Lipids
Male
Obesity
Polymerase Chain Reaction
Polymorphism, Genetic
Risk Factors
Statistical analysis
DM
GSTT1
GSTM1
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Summary:Abstract Background Diabetes is characterized by chronic hyperglycemia that produces dysregulation of cellular metabolism and result in excess free radical production and oxidative stress. Glutathione S-transferases (GSTs) are a family of multifunctional enzymes that work as antioxidants. Therefore, diminished expression of GSTs may result in a reduced body defense against oxidative stress, followed by development of diabetic complications. Objectives To investigate the possible association between GSTM1 and GSTT1 polymorphism and the occurrence of complications in type 2 DM and to study the other risk factors for complications in DM. Methods Twenty noncomplicated type 2 diabetic patients and 40 complicated type 2 diabetic patients were enrolled in the study. The GSTM1 and GSTT1 genotypes were identified by polymerase chain reaction of peripheral blood DNA samples. Analysis of data was done by using SPSS (SPSS, Chicago, Ill). Results The frequencies of null GSTM1 and GSTT1 genotypes were 55% (11/20) and 40% (8/20), respectively, in noncomplicated DM group. The frequencies of null GSTM1 and GSTT1 genotype in complicated DM group were 57.5% (23/40) and 60% (24/40), respectively. The null GSTT1 genotype was more prevalent in the group of complicated DM with odds ratio (odds ratio, 2.3; 95% confidence interval, 0.75-6.7) when compared with noncomplicated DM. Conclusion Our data provide evidence that diabetics with null GSTT1 genotypes are substantially at higher risk for developing complications.
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ISSN:0883-9441
1557-8615
DOI:10.1016/j.jcrc.2008.06.008