Tongue and teeth hyperpigmentation in etoposide, prednisolone, vincristine, and cyclophosphamide regimen in the treatment of cutaneous lymphoma

Cutaneous extranodal non-Hodgkin lymphoma is a rare cancer and chemotherapeutic agents like etoposide, vincristine and cyclophosphamide are the drug of choice, which rarely cause hyperpigmentation in skin and nails. However, herein we present a case of hyperpigmentation that was seen in tongue and e...

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Bibliographic Details
Published in:	Indian journal of pharmacology Vol. 55; no. 6; pp. 405 - 407
Main Authors:	Morabad, Soumya Shivalingappa, Khan, Zahed Ullah, Gad, Richa, Kallur, Nikitha, Madhabhavi, Irappa Vithoba, Shalavadi, Mallappa Hanumanthappa, Mangannavar, Chandrashekhar Venkaraddi
Format:	Journal Article
Language:	English
Published:	India Medknow Publications and Media Pvt. Ltd 01-11-2023 Medknow Publications & Media Pvt. Ltd Wolters Kluwer - Medknow
Subjects:	Antineoplastic Combined Chemotherapy Protocols - adverse effects Chemotherapy Complications and side effects Cyclophosphamide Cyclophosphamide - adverse effects Diagnosis Dosage and administration Doxorubicin - adverse effects Drug therapy Drug Watch Etoposide Etoposide - adverse effects Humans Hyperpigmentation - chemically induced Hyperpigmentation - drug therapy Intervention Lymphoma Lymphoma - drug therapy Lymphoma, Non-Hodgkin - drug therapy Lymphoma, Non-Hodgkin - pathology Non-Hodgkin's lymphomas Patient outcomes Pharmacology Prednisolone Prednisolone - adverse effects Prednisone - therapeutic use Skin Skin Neoplasms Teeth Tongue Tongue - pathology Vincristine Vincristine - adverse effects India hyperpigmentation Cyclophosphamide teeth tongue
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Summary:	Cutaneous extranodal non-Hodgkin lymphoma is a rare cancer and chemotherapeutic agents like etoposide, vincristine and cyclophosphamide are the drug of choice, which rarely cause hyperpigmentation in skin and nails. However, herein we present a case of hyperpigmentation that was seen in tongue and even in teeth. The hyperpigmentation of the tongue and teeth occurred shortly after the initiation of chemotherapy. Hyperpigmentation was self-limiting and rectified in a week without need of any pharmacological, surgical, or lifestyle interventions.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0253-7613 1998-3751 1998-3751
DOI:	10.4103/ijp.ijp_53_23