Search Results - "Khan, W I"

The role of serotonin and its receptors in activation of immune responses and inflammation by Shajib, M. S., Khan, W. I.

“…Serotonin or 5‐hydroxytryptamine (5‐HT) is a neurotransmitter and hormone that contributes to the regulation of various physiological functions by its actions…”
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Gut hormones: emerging role in immune activation and inflammation by Khan, W.I, Ghia, J.E

“…Gut inflammation is characterized by mucosal recruitment of activated cells from both the innate and adaptive immune systems. In addition to immune cells,…”
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Gut motor function: immunological control in enteric infection and inflammation by Khan, W. I., Collins, S. M.

“…Summary Alteration in gastrointestinal (GI) motility occurs in a variety of clinical settings which include acute enteritis, inflammatory bowel disease,…”
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Physiological changes in the gastrointestinal tract and host protective immunity: learning from the mouse-Trichinella spiralis model by Khan, W I

“…Infection and inflammation in the gastrointestinal (GI) tract induces a number of changes in the GI physiology of the host. Experimental infections with…”
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Intestinal Nematode Infection Ameliorates Experimental Colitis in Mice by KHAN, W. I, BLENNERHASSET, P. A, VARGHESE, A. K, CHOWDHURY, S. K, OMSTED, P, DENG, Y, COLLINS, S. M

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Helminth antigen-based strategy to ameliorate inflammation in an experimental model of colitis by Motomura, Y, Wang, H, Deng, Y, El-Sharkawy, R.T, Verdu, E.F, Khan, W.I

“…Inflammatory bowel disease (IBD) is the most common and serious chronic inflammatory condition of the gut. Among the distinct T helper (Th) cell subsets, a Th1…”
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Enterochromaffin cell and 5-hydroxytryptamine responses to the same infectious agent differ in Th1 and Th2 dominant environments by Motomura, Y, Ghia, J-E, Wang, H, Akiho, H, El-Sharkawy, R T, Collins, M, Wan, Y, McLaughlin, J T, Khan, W I

“…5-Hydroxytryptamine (5-HT) released from enterochromaffin cells influences intestinal homeostasis by altering gut physiology and is implicated in the…”
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Critical role of MCP-1 in the pathogenesis of experimental colitis in the context of immune and enterochromaffin cells by Khan, W I, Motomura, Y, Wang, H, El-Sharkawy, R T, Verdu, E F, Verma-Gandhu, M, Rollins, B J, Collins, S M

“…Mucosal changes in inflammatory bowel disease (IBD) are characterized by ulcerative lesions accompanied by a prominent infiltrate of inflammatory cells…”
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Modulation of Intestinal Muscle Contraction by Interleukin-9 (IL-9) or IL-9 Neutralization: Correlation with Worm Expulsion in Murine Nematode Infections by KHAN, W. I, RICHARD, M, AKIHO, H, BLENNERHASSET, P. A, HUMPHREYS, N. E, GRENCIS, R. K, VAN SNICK, J, COLLINS, S. M

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Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1 by Motomura, Y, Khan, W I, El-Sharkawy, R T, Verma-Gandhu, M, Verdu, E F, Gauldie, J, Collins, S M

“…Background and aims: Monocyte chemoattractant protein 1 (MCP-1) is increased transmurally in inflammatory bowel disease (IBD). Although MCP-1 is considered to…”
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Immune‐mediated alteration in gut physiology and its role in host defence in nematode infection by Khan, W. I., Collins, S. M.

“…SUMMARY Activation of the mucosal immune system of the gastrointestinal tract in nematode infection results in altered intestinal physiology, which includes…”
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Critical Role for Signal Transducer and Activator of Transcription Factor 6 in Mediating Intestinal Muscle Hypercontractility and Worm Expulsion in Trichinella spiralis-Infected Mice by KHAN, W. I, VALLANCE, B. A, BLENNERHASSETT, P. A, DENG, Y, VERDU, E. F, MATTHAEI, K. I, COLLINS, S. M

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Comparative study for removal of cationic dye from aqueous solutions by manganese oxide and manganese oxide composite by Saeed, T., Naeem, A., Mahmood, T., Ahmad, Z., Farooq, M., Farida, Din, I. U., Khan, I. W.

“…Manganese oxide-poly vinyl chloride (MnO 2 -PVC) composite has been synthesized for the removal of methylene blue from aqueous solution. Manganese oxide (MnO 2…”
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T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes by Chu, D K, Mohammed-Ali, Z, Jiménez-Saiz, R, Walker, T D, Goncharova, S, Llop-Guevara, A, Kong, J, Gordon, M E, Barra, N G, Gillgrass, A E, Van Seggelen, H, Khan, W I, Ashkar, A A, Bramson, J L, Humbles, A A, Kolbeck, R, Waserman, S, Jordana, M

“…Intestinal T helper type 2 (Th2) immunity in food allergy results in IgG1 and IgE production, and antigen re-exposure elicits responses such as anaphylaxis and…”
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The gene transfer of soluble VEGF type I receptor (Flt-1) attenuates peritoneal fibrosis formation in mice but not soluble TGF-beta type II receptor gene transfer by Motomura, Y, Kanbayashi, H, Khan, W I, Deng, Y, Blennerhassett, P A, Margetts, P J, Gauldie, J, Egashira, K, Collins, S M

“…Peritoneal fibrosis formation is a consequence of inflammation/injury and a significant medical problem to be solved. The effects of soluble VEGF receptor type…”
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Stat6 dependent goblet cell hyperplasia during intestinal nematode infection by Khan, W.I., Blennerhasset, P., Ma, C., Matthaei, K.I., Collins, S.M.

“…To identify the role of signal transducer and activator of transcription factor 6 (Stat6) in the development of intestinal goblet cell hyperplasia during…”
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Disruption of CD40-CD40 ligand pathway inhibits the development of intestinal muscle hypercontractility and protective immunity in nematode infection by Khan, W I, Motomura, Y, Blennerhassett, P A, Kanbayashi, H, Varghese, A K, El-Sharkawy, R T, Gauldie, J, Collins, S M

“…In our previous studies, we demonstrated that during Trichinella spiralis infection, T helper (Th) 2 cells contribute to the development of intestinal muscle…”
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Establishment of T-Helper-2 immune response based gerbil model of enteric infection by Sagar, M., Padol, I., Khan, W. I., Bonin, R. P., Blennerhassett, P. A., Hunt, R. H.

“…Background: The reciprocal antagonism of T-helper-1 (Th-1) and Th-2 type immune responses suggests that helminth parasitic infection may ameliorate disease…”
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Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling by Hanson, D, Murray, P G, Coulson, T, Sud, A, Omokanye, A, Stratta, E, Sakhinia, F, Bonshek, C, Wilson, L C, Wakeling, E, Temtamy, S A, Aglan, M, Rosser, E M, Mansour, S, Carcavilla, A, Nampoothiri, S, Khan, W I, Banerjee, I, Chandler, K E, Black, G C M, Clayton, P E

“…3-M syndrome is a primordial growth disorder caused by mutations in CUL7, OBSL1 or CCDC8. 3-M patients typically have a modest response to GH treatment, but…”
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IL-13-mediated immunological control of enterochromaffin cell hyperplasia and serotonin production in the gut by Manocha, M, Shajib, M S, Rahman, M M, Wang, H, Rengasamy, P, Bogunovic, M, Jordana, M, Mayer, L, Khan, W I

“…Enterochromaffin (EC) cells in the gastrointestinal (GI) mucosa are the main source of serotonin (5-hydroxytryptamine (5-HT)) in the body. 5-HT is implicated…”
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