Search Results - "Khan, Shara"

Autocrine activation of P2Y1 receptors couples Ca2+ influx to Ca2+ release in human pancreatic beta cells by Khan, Shara, Yan-Do, Richard, Duong, Eric, Wu, Xichen, Bautista, Austin, Cheley, Stephen, MacDonald, Patrick E., Braun, Matthias

“…Aims/hypothesis There is evidence that ATP acts as an autocrine signal in beta cells but the receptors and pathways involved are incompletely understood. Here…”
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A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets by Khan, Shara, Ferdaoussi, Mourad, Bautista, Austin, Bergeron, Valérie, Smith, Nancy, Poitout, Vincent, MacDonald, Patrick E.

“…Along with insulin, β‐cells co‐secrete the neurotransmitter ATP which acts as a positive autocrine signal via P2Y1 receptors to activate phospholipase C and…”
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A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human β-Cells and Is Impaired in Type 2 Diabetes by Yan-Do, Richard, Duong, Eric, Manning Fox, Jocelyn E, Dai, Xiaoqing, Suzuki, Kunimasa, Khan, Shara, Bautista, Austin, Ferdaoussi, Mourad, Lyon, James, Wu, Xichen, Cheley, Stephen, MacDonald, Patrick E, Braun, Matthias

“…The secretion of insulin from pancreatic islet β-cells is critical for glucose homeostasis. Disrupted insulin secretion underlies almost all forms of diabetes,…”
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Autocrine activation of P2Y1 receptors couples Ca (2+) influx to Ca (2+) release in human pancreatic beta cells by Khan, Shara, Yan-Do, Richard, Duong, Eric, Wu, Xichen, Bautista, Austin, Cheley, Stephen, MacDonald, Patrick E, Braun, Matthias

“…There is evidence that ATP acts as an autocrine signal in beta cells but the receptors and pathways involved are incompletely understood. Here we investigate…”
Get full text

SUMO1 enhances cAMP‐dependent exocytosis and glucagon secretion from pancreatic α‐cells by Dai, Xiao‐Qing, Spigelman, Aliya F., Khan, Shara, Braun, Matthias, Manning Fox, Jocelyn E., MacDonald, Patrick E.

“…Key points SUMOylation is the reversible modification of proteins by the attachment of small ubiquitin‐like modifier (SUMO) peptides, which in pancreatic…”
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Autocrine activation of P2Y^sub 1^ receptors couples Ca^sup 2+^ influx to Ca^sup 2+^ release in human pancreatic beta cells by Khan, Shara, Yan-do, Richard, Duong, Eric, Wu, Xichen, Bautista, Austin, Cheley, Stephen, Macdonald, Patrick E, Braun, Matthias

“…There is evidence that ATP acts as an autocrine signal in beta cells but the receptors and pathways involved are incompletely understood. Here we investigate…”
Get full text

SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic [alpha]-cells by Dai, Xiao-Qing, Spigelman, Aliya F, Khan, Shara, Braun, Matthias, Manning Fox, Jocelyn E, MacDonald, Patrick E

“…Key points SUMOylation is the reversible modification of proteins by the attachment of small ubiquitin-like modifier (SUMO) peptides, which in pancreatic…”
Get full text

A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human [Beta]-Cells and Is Impaired in Type 2 Diabetes by Yan-Do, Richard, Duong, Eric, Manning Fox, Jocelyn E, Dai, Xiaoqing, Suzuki, Kunimasa, Khan, Shara, Bautista, Austin, Ferdaoussi, Mourad, Lyon, James, Wu, Xichen, Cheley, Stephen, MacDonald, Patrick E, Braun, Matthias

“…The secretion of insulin from pancreatic islet β-cells is critical for glucose homeostasis. Disrupted insulin secretion underlies almost all forms of diabetes,…”
Get full text

35 - Activation of PKD1 by Autocrine ATP Signaling in Pancreatic β Cells by Khan, Shara, Ferdauossi, Mourad, Bergeron, Valérie, Smith, Nancy, Bautista, Austin, Macdonald, Patrick E.

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Activation of PKD1 by Autocrine ATP Signaling in Pancreatic β Cells by Khan, Shara, Ferdauossi, Mourad, Bergeron, Valérie, Smith, Nancy, Bautista, Austin, Macdonald, Patrick E.

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A role for PKD1 in insulin secretion downstream of P2Y 1 receptor activation in mouse and human islets by Khan, Shara, Ferdaoussi, Mourad, Bautista, Austin, Bergeron, Valérie, Smith, Nancy, Poitout, Vincent, MacDonald, Patrick E

“…Along with insulin, β-cells co-secrete the neurotransmitter ATP which acts as a positive autocrine signal via P2Y receptors to activate phospholipase C and…”
Get full text