Search Results - "Khan, Sanjoy"

Cell type-specific functions of period genes revealed by novel adipocyte and hepatocyte circadian clock models by Ramanathan, Chidambaram, Xu, Haiyan, Khan, Sanjoy K, Shen, Yang, Gitis, Paula J, Welsh, David K, Hogenesch, John B, Liu, Andrew C

“…In animals, circadian rhythms in physiology and behavior result from coherent rhythmic interactions between clocks in the brain and those throughout the body…”
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Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus by Xu, Haiyan, Gustafson, Chelsea L, Sammons, Patrick J, Khan, Sanjoy K, Parsley, Nicole C, Ramanathan, Chidambaram, Lee, Hsiau-Wei, Liu, Andrew C, Partch, Carrie L

“…The mammalian circadian cycle is determined by sequential activation of clock target-gene expression by CLOCK–BMAL and subsequent repression by CRY…”
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Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation by Luther, Jay, Khan, Sanjoy, Gala, Manish K., Kedrin, Dmitry, Sridharan, Gautham, Goodman, Russell P., Garber, John J., Masia, Ricard, Diagacomo, Erik, Adams, Daniel, King, Kevin R., Piaker, Samuel, Reinecker, Hans-Christian, Yarmush, Martin L., Argemi, Josepmaria, Bataller, Ramon, Dienstag, Jules L., Chung, Raymond T., Patel, Suraj J.

“…Alcohol-related liver disease (ALD) accounts for the majority of cirrhosis and liver-related deaths worldwide. Activation of IFN-regulatory factor (IRF3)…”
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Circadian regulation of ATP release in astrocytes by Marpegan, Luciano, Swanstrom, Adrienne E, Chung, Kevin, Simon, Tatiana, Haydon, Philip G, Khan, Sanjoy K, Liu, Andrew C, Herzog, Erik D, Beaulé, Christian

“…Circadian clocks sustain daily oscillations in gene expression, physiology, and behavior, relying on transcription-translation feedback loops of clock genes…”
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Identification of a Novel Cryptochrome Differentiating Domain Required for Feedback Repression in Circadian Clock Function by Khan, Sanjoy K., Xu, Haiyan, Ukai-Tadenuma, Maki, Burton, Brittany, Wang, Yongmei, Ueda, Hiroki R., Liu, Andrew C.

“…Background: Mammalian CRY1 and CRY2 have distinct functions in circadian clock mechanisms. Results: A core domain within the photolyase homology region of CRY1…”
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Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma by Kim, Wantae, Khan, Sanjoy Kumar, Liu, Yuchen, Xu, Ruoshi, Park, Ogyi, He, Yong, Cha, Boksik, Gao, Bin, Yang, Yingzi

“…Hippo signalling is a recently identified major oncosuppressive pathway that plays critical roles in inhibiting hepatocyte proliferation, survival and…”
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Fatty Acids Activate the Transcriptional Coactivator YAP1 to Promote Liver Fibrosis via p38 Mitogen-Activated Protein Kinase by Salloum, Shadi, Jeyarajan, Andre J., Kruger, Annie J., Holmes, Jacinta A., Shao, Tuo, Sojoodi, Mozhdeh, Kim, Myung-Ho, Zhuo, Zhu, Shroff, Stuti G., Kassa, Andrew, Corey, Kathleen E., Khan, Sanjoy K., Lin, Wenyu, Alatrakchi, Nadia, Schaefer, Esperance A.K., Chung, Raymond T.

“…Patients with simple steatosis (SS) and nonalcoholic steatohepatitis can develop progressive liver fibrosis, which is associated with liver-related mortality…”
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YAP mediates HIV-related liver fibrosis by Spalding, Volney A., Fellenstein, Brian A., Ahodantin, James, Jeyarajan, Andre J., Wang, Yongtao, Khan, Sanjoy K., Xu, Min, Lin, Wenyu, Alatrakchi, Nadia, Su, Lishan, Chung, Raymond T., Salloum, Shadi

“…HIV accelerates liver fibrosis attributable to multiple etiologies, including HCV, HBV, and steatotic liver disease. Evidence also suggests that HIV infection…”
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Monitoring cell-autonomous circadian clock rhythms of gene expression using luciferase bioluminescence reporters by Ramanathan, Chidambaram, Khan, Sanjoy K, Kathale, Nimish D, Xu, Haiyan, Liu, Andrew C

“…In mammals, many aspects of behavior and physiology such as sleep-wake cycles and liver metabolism are regulated by endogenous circadian clocks (reviewed). The…”
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Interacting network of Hippo, Wnt/β-catenin and Notch signaling represses liver tumor formation by Kim, Wantae, Khan, Sanjoy Kumar, Yang, Yingzi

“…Acquiring a selective growth advantage by breaking the proliferation barrier established by gatekeeper genes is a centrally important event in tumor formation…”
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Novel astaxanthin prodrug (CDX-085) attenuates thrombosis in a mouse model by Khan, Sanjoy K, Malinski, Tadeusz, Mason, R. Preston, Kubant, Ruslan, Jacob, Robert F, Fujioka, Kazutoshi, Denstaedt, Scott J, King, Timothy J, Jackson, Henry L, Hieber, A. David, Lockwood, Samuel F, Goodin, Thomas H, Pashkow, Fredric J, Bodary, Peter F

“…Abstract Background Cardiovascular disease remains the leading cause of morbidity and premature mortality in most industrialized countries as well as in…”
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Novel pyrazole-3-carboxamide derivatives as cannabinoid-1 (CB1) antagonists: Journey from non-polar to polar amides by Sasmal, Pradip K., Reddy, D. Srinivasa, Talwar, Rashmi, Venkatesham, B., Balasubrahmanyam, D., Kannan, M., Srinivas, P., Kyasa, Shiva K., Devi, B. Neelima, Jadhav, Vikram P., Khan, Sanjoy K., Mohan, Priya, Chaudhury, Hira, Bhuniya, Debnath, Iqbal, Javed, Chakrabarti, Ranjan

“…The synthesis and biological evaluation of novel pyrazole-3-carboxamide derivatives as CB1 antagonists are described. The in vivo proof of principle for weight…”
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Interacting network of Hippo, Wnt/β-catenin and Notch signaling represses liver tumor formation by Kim, Wantae, Khan, Sanjoy Kumar, Yang, Yingzi

“…Acquiring a selective growth advantage by breaking the proliferation barrier established by gatekeeper genes is a centrally important event in tumor formation…”
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Structure–activity relationship studies of novel pyrazole and imidazole carboxamides as cannabinoid-1 (CB1) antagonists by Sasmal, Pradip K., Talwar, Rashmi, Swetha, J., Balasubrahmanyam, D., Venkatesham, B., Rawoof, Khaji Abdul, Neelima Devi, B., Jadhav, Vikram P., Khan, Sanjoy K., Mohan, Priya, Srinivasa Reddy, D., Nyavanandi, Vijay Kumar, Nanduri, Srinivas, Kyasa, Shiva K., Kannan, M., Srinivas, P., Nadipalli, Prabhakar, Chaudhury, Hira, Sebastian, V.J.

“…The synthesis and biological evaluation of novel pyrazole and imidazole carboxamides as CB1 antagonists are described. The in vivo proof of principle for…”
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Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis by Kim, Wantae, Khan, Sanjoy Kumar, Gvozdenovic-Jeremic, Jelena, Kim, Youngeun, Dahlman, Jason, Kim, Hanjun, Park, Ogyi, Ishitani, Tohru, Jho, Eek-Hoon, Gao, Bin, Yang, Yingzi

“…Malignant tumors develop through multiple steps of initiation and progression, and tumor initiation is of singular importance in tumor prevention, diagnosis,…”
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Gα s signaling controls intramembranous ossification during cranial bone development by regulating both Hedgehog and Wnt/β-catenin signaling by Xu, Ruoshi, Khan, Sanjoy Kumar, Zhou, Taifeng, Gao, Bo, Zhou, Yaxing, Zhou, Xuedong, Yang, Yingzi

“…How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of…”
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Induced Gnas R201H expression from the endogenous Gnas locus causes fibrous dysplasia by up-regulating Wnt/β-catenin signaling by Khan, Sanjoy Kumar, Yadav, Prem Swaroop, Elliott, Gene, Hu, Dorothy Zhang, Xu, Ruoshi, Yang, Yingzi

“…Fibrous dysplasia (FD; Online Mendelian Inheritance in Man no. 174800) is a crippling skeletal disease caused by activating mutations of the gene, which…”
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Induced GnasR201H expression from the endogenous Gnas locus causes fibrous dysplasia by up-regulating Wnt/β-catenin signaling by Khan, Sanjoy Kumar, Yadav, Prem Swaroop, Elliott, Gene, Hu, Dorothy Zhang, Xu, Ruoshi, Yang, Yingzi

“…Fibrous dysplasia (FD; Online Mendelian Inheritance in Man no. 174800) is a crippling skeletal disease caused by activating mutations of the GNAS gene, which…”
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Correction: Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation by Luther, Jay, Khan, Sanjoy, Gala, Manish K., Kedrin, Dmitry, Sridharan, Gautham, Goodman, Russell P., Garber, John J., Masia, Ricard, Diagacomo, Erik, Adams, Daniel, King, Kevin R., Piaker, Samuel, Reinecker, Hans-Christian, Yarmush, Martin L., Argemi, Josepmaria, Bataller, Ramon, Dienstag, Jules L., Chung, Raymond T., Patel, Suraj J.

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Abstract 3337: Inhibition of KIF18A leads to mitotic arrest and robust anti-tumor activity in chromosomally instable tumors by Lynes, Maureen S., Khan, Sanjoy, Hotz, Taylor, Sparling, Brian A., Zablocki, Mary-Margaret, Gotur, Deepali, Boriack-Sjodin, P Ann, Duncan, Kenneth W., Blakemore, Stephen J., Silver, Serena J., Copeland, Robert A.

“…Abstract KIF18A is a plus-end directed kinesin known to play a role in mitosis by facilitating chromosome alignment and spindle microtubule dynamics. Knockdown…”
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