Search Results - "Khan, Samina Y."

Transfusion-related acute lung injury (TRALI): Current concepts and misconceptions by Silliman, Christopher C, Fung, Yoke Lin, Bradley Ball, J, Khan, Samina Y

“…Summary Transfusion-related acute lung injury (TRALI) is the most common cause of serious morbidity and mortality due to hemotherapy. Although the pathogenesis…”
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Plasma from stored packed red blood cells and MHC class I antibodies causes acute lung injury in a 2-event in vivo rat model by Kelher, Marguerite R., Masuno, Tomhiko, Moore, Ernest E., Damle, Sagar, Meng, Xianzhong, Song, Yong, Liang, Xiayuan, Niedzinski, Jerry, Geier, Steven S., Khan, Samina Y., Gamboni-Robertson, Fabia, Silliman, Christopher C.

“…Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion death. We hypothesize that TRALI requires 2 events: (1) the clinical…”
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Donor antibodies to HNA-3a implicated in TRALI reactions prime neutrophils and cause PMN-mediated damage to human pulmonary microvascular endothelial cells in a two-event in vitro model by Silliman, Christopher C., Curtis, Brian R., Kopko, Patricia M., Khan, Samina Y., Kelher, Marguerite R., Schuller, Randy M., Sannoh, Baindu, Ambruso, Daniel R.

“…Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality. Antibodies to HNA-3a are commonly implicated in TRALI. We…”
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Oncogenic and Angiogenic Growth Factors Accumulate during Routine Storage of Apheresis Platelet Concentrates by KANTER, Julie, KHAN, Samina Y, KELHER, Marguerite, GORE, Lia, SILLIMAN, Christopher C

“…Purpose: Platelet concentrates are important for support of patients with malignancies requiring myelotoxic chemotherapy. During storage, 10% to 15% of…”
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Identification of lipids that accumulate during the routine storage of prestorage leukoreduced red blood cells and cause acute lung injury by Silliman, Christopher C., Moore, Ernest E., Kelher, Marguerite R., Khan, Samina Y., Gellar, Lauren, Elzi, David J.

“…BACKGROUND: Lipids accumulate during the storage of red blood cells (RBCs), prime neutrophils (PMNs), and have been implicated in transfusion‐related acute…”
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Experimental prestorage filtration removes antibodies and decreases lipids in RBC supernatants mitigating TRALI in vivo by Silliman, Christopher C., Kelher, Marguerite R., Khan, Samina Y., LaSarre, Monica, West, F. Bernadette, Land, Kevin J., Mish, Barbara, Ceriano, Linda, Sowemimo-Coker, Samuel

“…Transfusion-related acute lung injury (TRALI) remains a significant cause of transfusion-related mortality with red cell transfusion. We hypothesize that…”
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Supernatants and lipids from stored red blood cells activate pulmonary microvascular endothelium through the BLT2 receptor and protein kinase C activation by Silliman, Christopher C., Kelher, Marguerite R., Khan, Samina Y., West, F. Bernadette, McLaughlin, Nathan J.D., Elzi, David J., England, Kelly, Bjornsen, Jason, Kuldanek, Susan A., Banerjee, Anirban

“…BACKGROUND Although transfusion is a lifesaving intervention, it may be associated with significant morbidity in injured patients. We hypothesize that stored…”
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α-Enolase Causes Proinflammatory Activation of Pulmonary Microvascular Endothelial Cells and Primes Neutrophils Through Plasmin Activation of Protease-Activated Receptor 2 by Bock, Ashley, Tucker, Nicole, Kelher, Marguerite R, Khan, Samina Y, Gonzalez, Eduardo, Wohlauer, Max, Hansen, Kirk, Dzieciatkowska, Monika, Sauaia, Angels, Banerjee, Anirban, Moore, Ernest E, Silliman, Christopher C

“…ABSTRACTProinflammatory activation of vascular endothelium leading to increased surface expression of adhesion molecules and neutrophil (PMN) sequestration and…”
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LysoPCs induce Hck‐ and PKCδ‐mediated activation of PKCγ causing p47phox phosphorylation and membrane translocation in neutrophils by Kelher, Marguerite R., McLaughlin, Nathan J. D., Banerjee, Anirban, Elzi, David J., Gamboni, Fabia, Khan, Samina Y., Meng, Xianzhong, Mitra, Sanchayita, Silliman, Christopher C.

“…Lysophosphatidylcholines (lysoPCs) are effective polymorphonuclear neutrophil (PMN) priming agents implicated in transfusion‐related acute lung injury (TRALI)…”
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Biological response modifiers in photochemically pathogen-reduced versus untreated apheresis platelet concentrates by Vetlesen, Annette, Mirlashari, Mohammad Reza, Akkök, Çiğdem Akalın, Kelher, Marguerite R., Khan, Samina Y., Silliman, Christopher C., Kjeldsen-Kragh, Jens

“…BACKGROUND: Lipids and other biologically active substances accumulate in platelet concentrates (PCs) during storage. Some of these substances have been…”
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Leukotriene b4 and its metabolites prime the neutrophil oxidase and induce proinflammatory activation of human pulmonary microvascular endothelial cells by Eun, John C, Moore, Ernest E, Banerjee, Anirban, Kelher, Marguerite R, Khan, Samina Y, Elzi, David J, McLaughlin, Nathan J D, Silliman, Christopher C

“…Leukotrienes are proinflammatory lipid mediators, derived from arachidonic acid via 5-lipoxygenase (5-LO). Leukotriene B4 (LTB4) is an effective…”
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Amantadine inhibits platelet-activating factor induced clathrin-mediated endocytosis in human neutrophils by Eckels, Phillip C, Banerjee, Anirban, Moore, Ernest E, McLaughlin, Nathan J D, Gries, Lynn M, Kelher, Marguerite R, England, Kelly M, Gamboni-Robertson, Fabia, Khan, Samina Y, Silliman, Christopher C

“…Receptor signaling is integral for adhesion, emigration, phagocytosis, and reactive oxygen species production in polymorphonuclear neutrophils (PMNs). Priming…”
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A two-event In vitro model of acute chest syndrome: The role of secretory phospholipase A2 and neutrophils by Ball, J. Bradley, Khan, Samina Y., McLaughlin, Nathan J.D., Kelher, Marguerite R., Nuss, Rachelle, Cole, Laura, Liang, Xiayuan, Silliman, Christopher C.

“…Background Acute chest syndrome (ACS) in sickle cell disease is associated with elevation of secretory phospholipase A2 (sPLA2). We hypothesize that sPLA2…”
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Tumor necrosis factor-alpha causes release of cytosolic interleukin-18 from human neutrophils by Silliman, Christopher C, Kelher, Marguerite R, Gamboni-Robertson, Fabia, Hamiel, Christine, England, Kelly M, Dinarello, Charles A, Wyman, Travis H, Khan, Samina Y, McLaughlin, Nathan J D, Bercovitz, Rachel S, Banerjee, Anirban

“…Neutrophils (PMNs) are a vital part of host defense and are the principal leukocyte in innate immunity. Interleukin (IL)-18 is a proinflammatory cytokine with…”
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LysoPCs induce Hck- and PKCδ-mediated activation of PKCγ causing p47 phox phosphorylation and membrane translocation in neutrophils by Kelher, Marguerite R, McLaughlin, Nathan J D, Banerjee, Anirban, Elzi, David J, Gamboni, Fabia, Khan, Samina Y, Meng, Xianzhong, Mitra, Sanchayita, Silliman, Christopher C

“…Abstract Lysophosphatidylcholines (lysoPCs) are effective polymorphonuclear neutrophil (PMN) priming agents implicated in transfusion-related acute lung injury…”
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Supernatants and Lipids from Stored RBCs Activate Pulmonary Microvascular Endothelium through the BLT2 Receptor and Protein Kinase C Activation by Silliman, Christopher C., Kelher, Marguerite R., Khan, Samina Y., West, F. Bernadette, McLaughlin, Nathan J. D., Elzi, David J., England, Kelly J., Bjornsen, Jason, Kuldanek, Susan A., Banerjee, Anirban

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α-enolase Causes Pro-Inflammatory Activation of Pulmonary Microvascular Endothelial Cells and Primes Neutrophils through Plasmin Activation of Protease-Activated Receptor-2 by Bock, Ashley, Tucker, Nicole, Kelher, Marguerite R., Khan, Samina Y., Gonzalez, Eduardo, Wohlauer, Max, Hansen, Kirk, Dzieciatkowska, Monika, Sauaia, Angels, Banerjee, Anirban, Moore, Ernest E., Silliman, Christopher C.

“…Pro-inflammatory activation of vascular endothelium leading to increased surface expression of adhesion molecules and neutrophil (PMN) sequestration and…”
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Experimental Antibody Filtration Inhibits Antibody-Mediated Neutrophil Priming and TRALI in An In Vivo model by Silliman, Christopher C, Kelher, Marguerite R, Khan, Samina Y, Sowemimo-Coker, Samuel O.

“…Abstract 41 Transfusion-related acute lung injury (TRALI) is a leading cause of transfusion-related death with a majority of the reported cases secondary to…”
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Reduction of sCD40L In Transfusable Plasma: A Potential TRALI Mitigation Strategy by Bercovitz, Rachel S, Kelher, Marguerite R, Khan, Samina Y, Berry, Travis H, Land, Kevin J, Silliman, Christopher C

“…Abstract 664 Soluble CD40 ligand (sCD40L) rapidly translocates to the surface of activated platelets and plays a role in the inflammatory cascade. sCD40L has…”
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A two‐event In vitro model of acute chest syndrome: The role of secretory phospholipase A 2 and neutrophils by Ball, J. Bradley, Khan, Samina Y., McLaughlin, Nathan J.D., Kelher, Marguerite R., Nuss, Rachelle, Cole, Laura, Liang, Xiayuan, Silliman, Christopher C.

“…Abstract Background Acute chest syndrome (ACS) in sickle cell disease is associated with elevation of secretory phospholipase A 2 (sPLA 2 ). We hypothesize…”
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