Search Results - "Khan, Sabab Hasan"

Ligand-induced shifts in conformational ensembles that describe transcriptional activation by Khan, Sabab Hasan, Braet, Sean M, Koehler, Stephen John, Elacqua, Elizabeth, Anand, Ganesh Srinivasan, Okafor, C Denise

“…Nuclear receptors function as ligand-regulated transcription factors whose ability to regulate diverse physiological processes is closely linked with…”
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Three-dimensional structure of a mycobacterial oligoribonuclease reveals a unique C-terminal tail that stabilizes the homodimer by Badhwar, Pooja, Khan, Sabab Hasan, Taneja, Bhupesh

“…Oligoribonucleases (Orns) are highly conserved DnaQ-fold 3′-5′ exoribonucleases that have been found to carry out the last step of cyclic-di-GMP (c-di-GMP)…”
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Identification of an Evolutionarily Conserved Allosteric Network in Steroid Receptors by Dube, Namita, Khan, Sabab Hasan, Sasse, Riley, Okafor, C. Denise

“…Allosteric pathways in proteins describe networks comprising amino acid residues which may facilitate the propagation of signals between distant sites. Through…”
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Interactions governing transcriptional activity of nuclear receptors by Khan, Sabab Hasan, Okafor, C Denise

“…The key players in transcriptional regulation are transcription factors (TFs), proteins that bind specific DNA sequences. Several mechanisms exist to turn TFs…”
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Structural and thermodynamic characterization of a highly stable conformation of Rv2966c, a 16S rRNA methyltransferase, at low pH by Khan, Sabab Hasan, Bijpuria, Shipra, Maurya, Anjali, Taneja, Bhupesh

“…Rv2966c is a highly specific methyltransferase that methylates G966 at the N2 position in 16S rRNA of mycobacterial ribosome and can be secreted inside the…”
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Protein folding: Molecular dynamics simulations and in vitro studies for probing mechanism of urea- and guanidinium chloride-induced unfolding of horse cytochrome-c by Khan, Sabab Hasan, Prakash, Amresh, Pandey, Preeti, Lynn, Andrew M., Islam, Asimul, Hassan, Md. Imtaiyaz, Ahmad, Faizan

“…Urea- and guanidinium chloride (GdmCl)-induced denatured states of horse cytochrome-c (cyt-c) are structurally identical. It is then expected that estimates of…”
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Effect of conservative mutations (L94V and L94I) on the structure and stability of horse cytochrome c by Khan, Sabab Hasan, Islam, Asimul, Hassan, Md. Imtaiyaz, Sharma, Sujata, Singh, Tej Pal, Ahmad, Faizan

“…A sequence alignment of horse cytochrome c (cyt c) with all known cyts c shows that Leu at position 94 is conserved, except in 14 species which have either Val…”
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Effects of natural mutations (L94I and L94V) on the stability and mechanism of folding of horse cytochrome c: A combined in vitro and molecular dynamics simulations approach by Khan, Sabab Hasan, Prakash, Amresh, Pandey, Preeti, Islam, Asimul, Hassan, Md. Imtaiyaz, Lynn, Andrew M., Ahmad, Faizan

“…Known crystal structures of 10 cytochromes (cyts) c from different sources led to the conclusion that natural mutations in these proteins does not affect their…”
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Mechanistic insights into the urea-induced denaturation of kinase domain of human integrin linked kinase by Syed, Sunayana Begum, Khan, Faez Iqbal, Khan, Sabab Hasan, Srivastava, Saurabha, Hasan, Gulam Mustafa, Lobb, Kevin A., Islam, Asimul, Ahmad, Faizan, Hassan, Md. Imtaiyaz

“…Integrin-linked kinase (ILK), a ubiquitously expressed intracellular Ser/Thr protein kinase, plays a major role in the oncogenesis and tumour progression. The…”
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Structural and thermodynamic characterisation of L94F mutant of horse cytochrome c by Khan, Sabab Hasan, kumar, Atul, Prakash, Amresh, Taneja, Bhupesh, Islam, Asimul, Hassan, Md. Imtiayaz, Ahmad, Faizan

“…⿢Mutation of Leu94 by Phe leads to misfolding of the horse cytochrome c.⿢Native L94F mutant at pH 6.0 and 25°C, has structural properties of molten…”
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Unravelling the unfolding mechanism of human integrin linked kinase by GdmCl-induced denaturation by Syed, Sunayana Begum, Khan, Faez Iqbal, Khan, Sabab Hasan, Srivastava, Saurabha, Hasan, Gulam Mustafa, Lobb, Kevin A., Islam, Asimul, Hassan, Md. Imtaiyaz, Ahmad, Faizan

“…Integrin-linked kinase (ILK) is a ubiquitously expressed Ser/Thr kinase which plays significant role in the cell-matrix interactions and growth factor…”
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Ancient and modern mechanisms compete in progesterone receptor activation by Khan, Sabab Hasan, Dube, Namita, Sudhakar, Nishanti, Fraser, Olivia, Villalona, Priscilla, Braet, Sean M, Leedom, Stephanie, Reilly, Erin R, Sivak, Jacob, Crittenden, Kenidee, Okafor, C. Denise

“…The progesterone receptor (PR) belongs to the steroid receptor family of ligand-regulated transcription factors, controlling genes important for development,…”
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