Search Results - "Khan, Omar M."

A review of coumarin derivatives in pharmacotherapy of breast cancer by Musa, Musiliyu A, Cooperwood, John S, Khan, M Omar F

“…The coumarin (benzopyran-2-one, or chromen-2-one) ring system, present in natural products (such as the anticoagulant warfarin) that display interesting…”
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Editorial: Cancer genomics in the era of precision medicine by Khan, Omar M, Mallardo, Domenico, Decock, Julie

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Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12 by Khan, Omar M., Almagro, Jorge, Nelson, Jessica K., Horswell, Stuart, Encheva, Vesela, Keyan, Kripa S., Clurman, Bruce E., Snijders, Ambrosius P., Behrens, Axel

“…The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal…”
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Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions by Akula, Murali K., Ibrahim, Mohamed X., Ivarsson, Emil G., Khan, Omar M., Kumar, Israiel T., Erlandsson, Malin, Karlsson, Christin, Xu, Xiufeng, Brisslert, Mikael, Brakebusch, Cord, Wang, Donghai, Bokarewa, Maria, Sayin, Volkan I., Bergo, Martin O.

“…Rho family proteins are prenylated by geranylgeranyltransferase type I (GGTase-I), which normally target proteins to membranes for GTP-loading. However,…”
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Synthesis and Pharmacology of Anti-Inflammatory Steroidal Antedrugs by Khan, M. Omar F, Lee, Henry J

“…Methods of chemical synthesis resulting in safer formulations of steroids are discussed. Pharmacological research has focused on ways of deactivating these…”
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FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2 by Jiménez-Izquierdo, Rafael, Morrugares, Rosario, Suanes-Cobos, Lucía, Correa-Sáez, Alejandro, Garrido-Rodríguez, Martín, Cerero-Tejero, Laura, Khan, Omar M., de la Luna, Susana, Sancho, Rocío, Calzado, Marco A.

“…FBXW7 is a member of the F-box protein family, which functions as the substrate recognition component of the SCF E3 ubiquitin ligase. FBXW7 is a main tumor…”
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Control of TGFβ signalling by ubiquitination independent function of E3 ubiquitin ligase TRIP12 by Keyan, Kripa S, Salim, Safa, Gowda, Swetha, Abdelrahman, Doua, Amir, Syeda Sakina, Islam, Zeyaul, Vargas, Claire, Bengoechea-Alonso, Maria Teresa, Alwa, Amira, Dahal, Subrat, Kolatkar, Prasanna R., Da’as, Sahar, Torrisani, Jerome, Ericsson, Johan, Mohammad, Farhan, Khan, Omar M

“…Transforming growth factor β (TGFβ) pathway is a master regulator of cell proliferation, differentiation, and death. Deregulation of TGFβ signalling is well…”
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Targeting GGTase-I Activates RHOA, Increases Macrophage Reverse Cholesterol Transport, and Reduces Atherosclerosis in Mice by KHAN, Omar M, AKULA, Murali K, SKALEN, Kristina, KARLSSON, Christin, STAHLMAN, Marcus, YOUNG, Stephen G, BOREN, Jan, BERGO, Martin O

“…Statins have antiinflammatory and antiatherogenic effects that have been attributed to inhibition of RHO protein geranylgeranylation in inflammatory cells. The…”
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Medicinal chemistry and emerging strategies applied to the development of selective estrogen receptor modulators (SERMs) by Musa, Musiliyu A, Khan, M Omar F, Cooperwood, John S

“…Selective estrogen receptor modulators (SERMs), known previously as "antiestrogens", are a new category of therapeutic agents used for the prevention and…”
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The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer by Khan, Omar M, Carvalho, Joana, Spencer-Dene, Bradley, Mitter, Richard, Frith, David, Snijders, Ambrosius P, Wood, Stephen A, Behrens, Axel

“…The tumor suppressor FBW7 targets oncoproteins such as c-MYC for ubiquitylation and is mutated in several human cancers. We noted that in a substantial…”
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Readiness of Pharmacists as Providers of Social Determinants of Health and Call to Action by Khan, M. Omar Faruk, Ried, L. Douglas

“…Social determinants of health (SDOH) are defined as the conditions in the environments where people are born, live, learn, work, play, worship, and age. SDOH…”
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E3 Ubiquitin Ligase TRIP12 Controls Exit from Mitosis via Positive Regulation of MCL-1 in Response to Taxol by Keyan, Kripa S, Alanany, Rania, Kohil, Amira, Khan, Omar M

“…Chemotherapy resistance is a major hurdle in cancer treatment. Taxol-based chemotherapy is widely used in the treatment of cancers including breast, ovarian,…”
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Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal and antileishmanial drug design by Khan, M Omar F

“…Trypanosomiasis and leishmaniasis are two debilitating disease groups caused by parasites of Trypanosoma and Leishmania spp. and affecting millions of people…”
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The Trends of CRP Levels at Different Waist-to-Hip Ratios Among Normotensive Overweight and Obese Patients: A Pilot Study by Firdous, Samar, Khan Lodhi, M Omar, Siddique, Kashif

“…To determine the correlation between CRP (C-reactive protein) and Waist to Hip Ratio (WHR) among over weight and obese patients with normal blood pressure. An…”
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A small Rho GTPase RAB25 with a potential role in chemotherapy resistance in pancreatic cancer by Kohil, Amira, Amir, Sayeda S, Behrens, Axel, Khan, Omar M

“…Pancreatic ductal adenocarcinoma (PDA) is one of the major human health challenges with minimal therapeutic benefits due to its late detection, and de novo -…”
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Antedrugs: an approach to safer drugs by Khan, M Omar F, Park, Kwan K, Lee, Henry J

“…The antedrug concept was introduced by Lee and Soliman in 1982 in designing potent, yet safer locally active anti-inflammatory steroids. Antedrug is defined as…”
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Multiband High-Gain Printed Yagi Array Using Square Spiral Ring Metamaterial Structures for S-Band Applications by Khan, Omar M., Islam, Zain U., Islam, Qamar U., Bhatti, Farooq A.

“…This letter presents the design, implementation, and measured results of a novel multiband square spiral ring (SSR) metamaterial-embedded printed Yagi antenna…”
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Loss of One Copy of Zfp148 Reduces Lesional Macrophage Proliferation and Atherosclerosis in Mice by Activating p53 by Sayin, Volkan I, Khan, Omar M, Pehlivanoglu, Lara E, Staffas, Anna, Ibrahim, Mohamed X, Asplund, Annika, Ågren, Pia, Nilton, Anna, Bergström, Göran, Bergo, Martin O, Borén, Jan, Lindahl, Per

“…RATIONALE:Cell proliferation and cell cycle control mechanisms are thought to play central roles in the pathogenesis of atherosclerosis. The transcription…”
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Repeated Quantitative Urine Toxicology Analysis May Improve Chronic Pain Patient Compliance with Opioid Therapy by Knezevic, Nebojsa Nick, Khan, Omar M, Beiranvand, Afsaneh, Candido, Kenneth D

“…Even though serious efforts have been undertaken by different medical societies to reduce opioid use for treating chronic benign pain, many Americans continue…”
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Tetraazamacrocyclic derivatives and their metal complexes as antileishmanial leads by Hubin, Timothy J., Walker, Ashlie N., Davilla, Dustin J., Carder Freeman, TaRynn N., Epley, Brittany M., Hasley, Travis R., Amoyaw, Prince N.A., Jain, Surendra, Archibald, Stephen J., Prior, Timothy J., Krause, Jeanette A., Oliver, Allen G., Tekwani, Babu L., Khan, M. Omar F.

“…Several bis-aryl-monocyclic polyamines and their metal complexes were shown to be potent in vitro inhibitors of Leishmania donovani. The synthesis of the two…”
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