Search Results - "Khan, Omar"

Nucleic acid delivery differences across species by Khan, Omar F.

“…Examining nucleic acid delivery in humanized animal models might accelerate nanoparticle optimization and potentially improve clinical translation strategies…”
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A review of coumarin derivatives in pharmacotherapy of breast cancer by Musa, Musiliyu A, Cooperwood, John S, Khan, M Omar F

“…The coumarin (benzopyran-2-one, or chromen-2-one) ring system, present in natural products (such as the anticoagulant warfarin) that display interesting…”
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HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications by Khan, Omar, La Thangue, Nicholas B

“…Reversible acetylation mediated by histone deacetylases (HDACs) influences a broad repertoire of physiological processes, many of which are aberrantly…”
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Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure by Sager, Hendrik B, Hulsmans, Maarten, Lavine, Kory J, Moreira, Marina B, Heidt, Timo, Courties, Gabriel, Sun, Yuan, Iwamoto, Yoshiko, Tricot, Benoit, Khan, Omar F, Dahlman, James E, Borodovsky, Anna, Fitzgerald, Kevin, Anderson, Daniel G, Weissleder, Ralph, Libby, Peter, Swirski, Filip K, Nahrendorf, Matthias

“…RATIONALE:Macrophages reside in the healthy myocardium, participate in ischemic heart disease and modulate myocardial infarction (MI) healing. Their origin and…”
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A Perspective on the Clinical Translation of Scaffolds for Tissue Engineering by Webber, Matthew J., Khan, Omar F., Sydlik, Stefanie A., Tang, Benjamin C., Langer, Robert

“…Scaffolds have been broadly applied within tissue engineering and regenerative medicine to regenerate, replace, or augment diseased or damaged tissue. For a…”
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Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose by Chahal, Jasdave S., Khan, Omar F., Cooper, Christopher L., McPartlan, Justine S., Tsosie, Jonathan K., Tilley, Lucas D., Sidik, Saima M., Lourido, Sebastian, Langer, Robert, Bavari, Sina, Ploegh, Hidde L., Anderson, Daniel G.

“…Vaccines have had broad medical impact, but existing vaccine technologies and production methods are limited in their ability to respond rapidly to evolving…”
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Beyond Medical “Missions” to Impact-Driven Short-Term Experiences in Global Health (STEGHs): Ethical Principles to Optimize Community Benefit and Learner Experience by Melby, Melissa K., Loh, Lawrence C., Evert, Jessica, Prater, Christopher, Lin, Henry, Khan, Omar A.

“…Increasing demand for global health education in medical training has driven the growth of educational programs predicated on a model of short-term medical…”
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A Cell-Free Kinetic Analysis of Ionizable Lipid Hydrolysis by Couture-Senécal, Julien, Natraj, Jagriti, Khan, Omar F.

“…The prolonged retention of ionizable lipids within the body limits the repeated dosing of lipid nanoparticles (LNPs) for nucleic acid delivery. While most…”
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An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model by Chahal, Jasdave S., Fang, Tao, Woodham, Andrew W., Khan, Omar F., Ling, Jingjing, Anderson, Daniel G., Ploegh, Hidde L.

“…The Zika virus (ZIKV) outbreak in the Americas and South Pacific poses a significant burden on human health because of ZIKV’s neurotropic effects in the course…”
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Future Directions of Training Physician–Scientists: Reimagining and Remeasuring the Workforce by Bensken, Wyatt P, Nath, Avindra, Heiss, John D, Khan, Omar I

“…In academic medicine, the attrition of the physician–scientist workforce has been significantly discussed for the past three decades, with substantial…”
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Influence of Research Continuity on Physician-Scientists’ Career Success by Brownrout, Jenna, Norato, Gina, Bensken, Wyatt, Squirewell, Catherine, Gordon, Taylor, Heiss, John, Nath, Avindra, Khan, Omar I.

“…To determine if maintaining continuity in research topic and method from early to late career yields a greater likelihood of physician-scientists' research…”
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Coloniality, just war & carceral injustice in Brazil by Darke, Sacha, Khan, Omar Phoenix

“…The Portuguese empire brought inescapable violence to the indigenous communities of Brazil and to those it enslaved. Throughout the centuries of colonial…”
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Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis by Hussain, Azhar R, Ahmed, Saeeda O, Ahmed, Maqbool, Khan, Omar S, Al Abdulmohsen, Sally, Platanias, Leonidas C, Al-Kuraya, Khawla S, Uddin, Shahab

“…A number of constitutively activated signaling pathways play critical roles in the survival and growth of primary effusion lymphoma cells (PELs) including NFkB…”
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Use of Machine Learning and Artificial Intelligence to Drive Personalized Medicine Approaches for Spine Care by Khan, Omar, Badhiwala, Jetan H., Grasso, Giovanni, Fehlings, Michael G.

“…Personalized medicine is a new paradigm of healthcare in which interventions are based on individual patient characteristics rather than on “one-size-fits-all”…”
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Gastrojejunostomy Closure Technique and Risk of Leak: an Evaluation in Ex Vivo Porcine Models by Das, Bibek, Ledesma, Frances, Ashrafian, Hutan, Reddy, Marcus, Khan, Omar A., Fehervari, Matyas

“…Introduction Roux-en-Y gastric bypass (RYGB) is one of the most commonly performed bariatric operations worldwide. Leaks following RYGB are rare, but the…”
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Small RNA combination therapy for lung cancer by Xue, Wen, Dahlman, James E., Tammela, Tuomas, Khan, Omar F., Sood, Sabina, Dave, Apeksha, Cai, Wenxin, Chirino, Leilani M., Yang, Gillian R., Bronson, Roderick, Crowley, Denise G., Sahay, Gaurav, Schroeder, Avi, Langer, Robert, Anderson, Daniel G., Jacks, Tyler

“…MicroRNAs (miRNAs) and siRNAs have enormous potential as cancer therapeutics, but their effective delivery to most solid tumors has been difficult. Here, we…”
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Bariatric surgery for patients with type 2 diabetes mellitus requiring insulin: Clinical outcome and cost-effectiveness analyses by McGlone, Emma Rose, Carey, Iain, Veličković, Vladica, Chana, Prem, Mahawar, Kamal, Batterham, Rachel L, Hopkins, James, Walton, Peter, Kinsman, Robin, Byrne, James, Somers, Shaw, Kerrigan, David, Menon, Vinod, Borg, Cynthia, Ahmed, Ahmed, Sgromo, Bruno, Cheruvu, Chandra, Bano, Gul, Leonard, Catherine, Thom, Howard, le Roux, Carel W, Reddy, Marcus, Welbourn, Richard, Small, Peter, Khan, Omar A

“…Although bariatric surgery is well established as an effective treatment for patients with obesity and type 2 diabetes mellitus (T2DM), there exists reluctance…”
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The Syndrome of Large Healed Single Discrete Myocardial Infarct with Severe Narrowing of Only One Major Epicardial Coronary Artery and Leading to Severe Chronic Heart Failure and Orthotopic Heart Transplantation by Roberts, William C., Khan, Omar S.

“…Described herein are clinical and cardiac morphologic findings in 12 patients (age 43 to 70 years) (7 men) who underwent orthotopic heart transplantation (OHT)…”
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The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer by Khan, Omar M, Carvalho, Joana, Spencer-Dene, Bradley, Mitter, Richard, Frith, David, Snijders, Ambrosius P, Wood, Stephen A, Behrens, Axel

“…The tumor suppressor FBW7 targets oncoproteins such as c-MYC for ubiquitylation and is mutated in several human cancers. We noted that in a substantial…”
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Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression by Yu, Dou, Khan, Omar F., Suvà, Mario L., Dong, Biqin, Panek, Wojciech K., Xiao, Ting, Wu, Meijing, Han, Yu, Ahmed, Atique U., Balyasnikova, Irina V., Zhang, Hao F., Sun, Cheng, Langer, Robert, Anderson, Daniel G., Lesniak, Maciej S.

“…Brain tumor-initiating cells (BTICs) have been identified as key contributors to therapy resistance, recurrence, and progression of diffuse gliomas,…”
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