Search Results - "Khan, Nayaab S"

Estrogen Metabolism by Cytochrome P450 1B1 Modulates the Hypertensive Effect of Angiotensin II in Female Mice by Jennings, Brett L, George, L Watson, Pingili, Ajeeth K, Khan, Nayaab S, Estes, Anne M, Fang, Xiao R, Gonzalez, Frank J, Malik, Kafait U

“…To determine the role of cytochrome P450 (CYP) 1B1 in the sex difference in response to angiotensin II (Ang II)–induced hypertension, female Cyp1b1 and Cyp1b1…”
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Nicotinic acetylcholine receptor-mediated protection of the rat heart exposed to ischemia reperfusion by Mavropoulos, Spyros A, Khan, Nayaab S, Levy, Asaph C J, Faliks, Bradley T, Sison, Cristina P, Pavlov, Valentin A, Zhang, Youhua, Ojamaa, Kaie

“…Reperfusion injury following acute myocardial infarction is associated with significant morbidity. Activation of neuronal or non-neuronal cholinergic pathways…”
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Single-cell immune landscape of human atherosclerotic plaques by Fernandez, Dawn M., Rahman, Adeeb H., Fernandez, Nicolas F., Chudnovskiy, Aleksey, Amir, El-ad David, Amadori, Letizia, Khan, Nayaab S., Wong, Christine K., Shamailova, Roza, Hill, Christopher A., Wang, Zichen, Remark, Romain, Li, Jennifer R., Pina, Christian, Faries, Christopher, Awad, Ahmed J., Moss, Noah, Bjorkegren, Johan L. M., Kim-Schulze, Seunghee, Gnjatic, Sacha, Ma’ayan, Avi, Mocco, J, Faries, Peter, Merad, Miriam, Giannarelli, Chiara

“…Atherosclerosis is driven by multifaceted contributions of the immune system within the circulation and at vascular focal sites. However, specific…”
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A patent update on cannabinoid receptor 1 antagonists (2015-2018) by Amato, George, Khan, Nayaab S, Maitra, Rangan

“…The endocannabinoid system is an important regulator of various physiological processes. Preclinical and clinical studies indicate that attenuation of the…”
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6β-Hydroxytestosterone, a Cytochrome P450 1B1 Metabolite of Testosterone, Contributes to Angiotensin II–Induced Hypertension and Its Pathogenesis in Male Mice by Pingili, Ajeeth K, Kara, Mehmet, Khan, Nayaab S, Estes, Anne M, Lin, Zongtao, Li, Wei, Gonzalez, Frank J, Malik, Kafait U

“…Previously, we showed that Cyp1b1 gene disruption minimizes angiotensin II–induced hypertension and associated pathophysiological changes in male mice. This…”
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2-Methoxyestradiol Reduces Angiotensin II–Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice by Pingili, Ajeeth K, Davidge, Karen N, Thirunavukkarasu, Shyamala, Khan, Nayaab S, Katsurada, Akemi, Majid, Dewan S.A, Gonzalez, Frank J, Navar, L Gabriel, Malik, Kafait U

“…Cytochrome P450 1B1 protects against angiotensin II (Ang II)–induced hypertension and associated cardiovascular changes in female mice, most likely via…”
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Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice by Song, Chi Young, Ghafoor, Khuzema, Ghafoor, Hafiz U, Khan, Nayaab S, Thirunavukkarasu, Shyamala, Jennings, Brett L, Estes, Anne M, Zaidi, Sahar, Bridges, Dave, Tso, Patrick, Gonzalez, Frank J, Malik, Kafait U

“…Cytochrome P450 (CYP) 1B1 contributes to vascular smooth muscle cell growth and hypertension in male mice. This study was conducted to determine the…”
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Cytochrome P450 1B1 Contributes to the Development of Angiotensin II–Induced Aortic Aneurysm in Male Apoe−/− Mice by Thirunavukkarasu, Shyamala, Khan, Nayaab S, Song, Chi Young, Ghafoor, Hafiz U, Brand, David D, Gonzalez, Frank J, Malik, Kafait U

“…Cytochrome P450 (CYP) 1B1 is implicated in vascular smooth muscle cell migration, proliferation, and hypertension. We assessed the contribution of CYP1B1 to…”
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Cytosolic Phospholipase A2α Is Critical for Angiotensin II–Induced Hypertension and Associated Cardiovascular Pathophysiology by Khan, Nayaab S, Song, Chi Young, Jennings, Brett L, Estes, Anne M, Fang, Xiao R, Bonventre, Joseph V, Malik, Kafait U

“…Angiotensin II activates cytosolic phospholipase Aα (cPLA2α) and releases arachidonic acid from tissue phospholipids, which mediate or modulate ≥1…”
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Cytosolic Phospholipase A2α Is Essential for Renal Dysfunction and End-Organ Damage Associated With Angiotensin II-Induced Hypertension by Khan, Nayaab S., Song, Chi Young, Thirunavukkarasu, Shyamala, Fang, Xiao R., Bonventre, Joseph V., Malik, Kafait U.

“…BACKGROUND The kidney plays an important role in regulating blood pressure (BP). cPLA2α in the kidney is activated by various agents including angiotensin II…”
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Clotrimazole-cyclodextrin based approach for the management and treatment of Candidiasis - A formulation and chemistry-based evaluation by Mohammed, Noorullah Naqvi, Pandey, Pankaj, Khan, Nayaab S., Elokely, Khaled M., Liu, Haining, Doerksen, Robert J., Repka, Michael A.

“…Clotrimazole (CT) is a poorly soluble antifungal drug that is most commonly employed as a topical treatment in the management of vaginal candidiasis. The…”
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Abstract P242: Nicotinic Acetylcholine Receptor Subunit α7 is Protective Against Angiotensin II-induced Aneurysm and Hypertension by Khan, Nayaab S, Mavropoulos, Spyros, Ojamaa, Kaie

“…Abstract only Alpha7 nicotinic acetylcholine receptor (α7 nAChR), an integral component of the cholinergic nervous system is known to mediate cholinergic…”
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A Peripherally Selective CB1 Receptor Inverse Agonist Improves Metabolic Syndrome in Mice by Khan, Nayaab S, Amato, George, Vasukuttan, Vineetha, Wang, Shaobin, Snyder, Rodney, Rosa, Taylor, Wiethe, Robert, Hackney, Aliah, Runyon, Scott, Maitra, Rangan

“…The type 1 cannabinoid receptor (CB1) can be targeted to treat major diseases like type 2 diabetes, fibrosis and steatohepatitis. This has led to the…”
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Brain Cytosolic Phospholipase A2α Mediates Angiotensin II-Induced Hypertension and Reactive Oxygen Species Production in Male Mice by Song, Chi Young, Khan, Nayaab S, Liao, Francesca-Fang, Wang, Bin, Shin, Ji Soo, Bonventre, Joseph V, Malik, Kafait U

“…Abstract BACKGROUND Recently, we reported that angiotensin II (Ang II)-induced hypertension is mediated by group IV cytosolic phospholipase A2α (cPLA2α) via…”
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Abstract P135: 2-methoxyestradiol Minimizes Angiotensin II-induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice by Pingili, Ajeeth K, Thirunavukkarasu, Shyamala, Khan, Nayaab S, Katsurada, Akemi, Majid, Dewan S, Navar, Gabriel L, Malik, Kafait U

“…Abstract only Men and post-menopausal females are more prone to develop hypertension and renal dysfunction as compared to pre-menopausal females. It is well…”
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Abstract 301: Cytochrome P450 1b1 is Essential for the Development of Aortic Aneurysm in ApoE Knockout Mice by Thirunavukkarasu, Shyamala, Khan, Nayaab S, Ghafoor, Hafiz U, Jennings, Brett L, Malik, Kafait U

“…Abstract only Previously we have shown that the development of hypertension and neointimal growth is dependent on cytochrome P450 (CYP)1B1 activity. This study…”
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Cytosolic Phospholipase A 2 α Is Essential for Renal Dysfunction and End-Organ Damage Associated With Angiotensin II-Induced Hypertension by Khan, Nayaab S., Song, Chi Young, Thirunavukkarasu, Shyamala, Fang, Xiao R., Bonventre, Joseph V., Malik, Kafait U.

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Abstract 249: Modulation of Angiotensin II-Induced Hypertension by Cytochrome P450 1B1 Metabolites of Estrogen in Female Mice by Jennings, Brett L, Pingili, Ajeeth K, Khan, Nayaab S, Malik, Kafait U

“…Abstract only Pre-menopausal females are less susceptible to increases in blood pressure (BP) compared to males in various models of experimental hypertension,…”
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Abstract 155: Group IV Cytosolic Phospholipase A 2 a Disruption Protects Against Angiotensin II-Induced Hypertension and End Organ Damage by Khan, Nayaab S, Song, Chi Young, Bonventre, Joseph V, Malik, Kafait U

“…Abstract only Previously we have shown that Group IV cytosolic phospholipase A 2 α (cPLA 2 α) is critical for the development of angiotensin (Ang) II-induced…”
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Abstract 252: 6ß-Hydroxytestosterone, A Cytochrome P450 1B1 Metabolite of Testosterone, Enhances Angiotensin II-Induced Pressor Effect in Male Mice by Pingili, Ajeeth K, Jennings, Brett L, Khan, Nayaab S, Malik, Kafait U

“…Abstract only Androgens have been implicated in the development of hypertension and castration minimizes the pressor effect of angiotensin (Ang) II. Previously…”
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