Search Results - "Khan, Md Abdul Hye"

Fructose Stimulates Na/H Exchange Activity and Sensitizes the Proximal Tubule to Angiotensin II by Cabral, Pablo D., Hong, Nancy J., Khan, Md. Abdul Hye, Ortiz, Pablo A., Beierwaltes, William H., Imig, John D., Garvin, Jeffrey L.

“…The proximal nephron reabsorbs 60% to 70% of the fluid and sodium and most of the filtered bicarbonate via Na/H exchanger 3. Enhanced proximal nephron…”
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Orally Active Epoxyeicosatrienoic Acid Analog Attenuates Kidney Injury in Hypertensive Dahl Salt–Sensitive Rat by Hye Khan, Md Abdul, Neckář, Jan, Manthati, Vijay, Errabelli, Ramu, Pavlov, Tengis S, Staruschenko, Alexander, Falck, John R, Imig, John D

“…Salt-sensitive hypertension leads to kidney injury. The Dahl salt–sensitive hypertensive rat (Dahl SS) is a model of salt-sensitive hypertension and…”
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Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats by Neckář, Jan, Hye Khan, Md Abdul, Gross, Garrett J, Cyprová, Michaela, Hrdlička, Jaroslav, Kvasilová, Alena, Falck, John R, Campbell, William B, Sedláková, Lenka, Škutová, Šárka, Olejníčková, Veronika, Gregorovičová, Martina, Sedmera, David, Kolář, František, Imig, John D

“…Epoxyeicosatrienoic acids (EETs) and their synthetic analogs have cardiovascular protective effects. Here, we investigated the action of a novel EET analog…”
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Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition by Hye Khan, Md Abdul, Pavlov, Tengis S, Christain, Sarah V, Neckář, Jan, Staruschenko, Alexander, Gauthier, Kathryn M, Capdevila, Jorge H, Falck, John R, Campbell, William B, Imig, John D

“…Epoxyeicosatrienoic acids (EETs) contribute to haemodynamics, electrolyte homoeostasis and blood pressure regulation, leading to the concept that EETs can be…”
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Epoxyeicosatrienoic Acid Analog Decreases Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition by Skibba, Melissa, Hye Khan, Md Abdul, Kolb, Lauren L, Yeboah, Michael M, Falck, John R, Amaradhi, Radhika, Imig, John D

“…Renal fibrosis, which is a critical pathophysiological event in chronic kidney diseases, is associated with renal epithelial-to-mesenchymal transition (EMT)…”
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Epoxyeicosatrienoic Acid Analog EET-A Blunts Development of Lupus Nephritis in Mice by Hye Khan, Md Abdul, Stavniichuk, Anna, Sattar, Mohammad Abdul, Falck, John R, Imig, John D

“…Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disorder that causes life threatening renal disease and current therapies are limited…”
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Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis by Sharma, Amit, Hye Khan, Md Abdul, Levick, Scott P, Lee, Kin Sing Stephen, Hammock, Bruce D, Imig, John D

“…Cytochrome P450 (CYP) monooxygenases epoxidize the omega-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid into novel epoxydocosapentaenoic acids (EDPs)…”
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Azilsartan Decreases Renal and Cardiovascular Injury in the Spontaneously Hypertensive Obese Rat by Khan, Md. Abdul Hye, Neckář, Jan, Cummens, Breana, Wahl, Geneva M., Imig, John D.

“…Purpose Angiotensin II type 1 receptor blockers (ARBs) are widely used in treating hypertension. In the present study, we tested the hypothesis that a novel…”
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Azilsartan Improves Glycemic Status and Reduces Kidney Damage in Zucker Diabetic Fatty Rats by Khan, Md. Abdul Hye, Neckář, Jan, Haines, Jasmine, Imig, John D.

“…BACKGROUND Azilsartan medoxomil (AZL-M), an angiotensin II receptor blocker, demonstrates antihypertensive and organ protective effects in hypertension. We…”
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Radiation-induced afferent arteriolar endothelial-dependent dysfunction involves decreased epoxygenase metabolites by Imig, John D, Hye Khan, Md Abdul, Sharma, Amit, Fish, Brian L, Mandel, Neil S, Cohen, Eric P

“…Chronic kidney disease is a known complication of hematopoietic stem cell transplant (HSCT) and can be caused by irradiation at the time of the HSCT. In our…”
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Epoxyeicosatrienoic acid analog attenuates angiotensin II hypertension and kidney injury by Khan, Abdul Hye, Falck, John R, Manthati, Vijaya L, Campbell, William B, Imig, John D

“…Epoxyeicosatrienoic acids (EETs) contribute to blood pressure regulation leading to the concept that EETs can be therapeutically targeted for hypertension and…”
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A dual farnesoid X receptor/soluble epoxide hydrolase modulator treats non-alcoholic steatohepatitis in mice by Hye Khan, Md. Abdul, Schmidt, Jurema, Stavniichuk, Anna, Imig, John D., Merk, Daniel

“…[Display omitted] Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are the most prevalent metabolic liver disorders and a…”
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A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes by Hye Khan, Md Abdul, Kolb, Lauren, Skibba, Melissa, Hartmann, Markus, Blöcher, René, Proschak, Ewgenij, Imig, John D.

“…Aims/hypothesis The metabolic syndrome is a cluster of risk correlates that can progress to type 2 diabetes. The present study aims to evaluate a novel…”
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Multitarget molecule, PTUPB, to treat diabetic nephropathy in rats by Khan, Md. Abdul Hye, Hwang, Sung Hee, Barnett, Scott D., Stavniichuk, Anna, Jankiewicz, Wojciech K., Hammock, Bruce D., Imig, John D.

“…Background and Purpose Diabetic nephropathy is a common complications related to high morbidity and mortality in type 2 diabetes. We investigated the action of…”
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The contribution of α1B-adrenoceptor subtype in the renal vasculature of fructose-fed Sprague–Dawley rats by Abdulla, Mohammed H., Sattar, Munavvar A., Abdullah, Nor A., Khan, Md. Abdul Hye, Anand Swarup, Kolla R. L., Johns, Edward J.

“…Purpose Fructose feeding induces a moderate increase in blood pressure, insulin resistance, and hyperinsulinemia. This study investigated the role of α 1B…”
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Dual soluble epoxide hydrolase inhibitor - farnesoid X receptor agonist interventional treatment attenuates renal inflammation and fibrosis by Khan, Md Abdul Hye, Nolan, Benjamin, Stavniichuk, Anna, Merk, Daniel, Imig, John D

“…Renal fibrosis associated with inflammation is a critical pathophysiological event in chronic kidney disease (CKD). We have developed DM509 which acts…”
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Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia-inducible factor-1α via downregulation of prolyl hydroxylase 3 by Neckář, Jan, Hsu, Anna, Hye Khan, Md Abdul, Gross, Garrett J, Nithipatikom, Kasem, Cyprová, Michaela, Benák, Daniel, Hlaváčková, Markéta, Sotáková-Kašparová, Dita, Falck, John R, Sedmera, David, Kolář, František, Imig, John D

“…Epoxyeicosatrienoic acids (EETs) decrease cardiac ischemia-reperfusion injury; however, the mechanism of their protective effect remains elusive. Here, we…”
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Kidney-Targeted Epoxyeicosatrienoic Acid Analog, EET-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity by Imig, John D, Hye Khan, Md Abdul, Burkhan, Anna, Chen, Guan, Adebesin, Adeniyi Michael, Falck, John R

“…Although epoxyeicosatrienoic acid (EET) analogs have performed well in several acute and chronic kidney disease models, targeted delivery of EET analogs to the…”
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Dual soluble epoxide hydrolase inhibitor/PPAR-γ agonist attenuates renal fibrosis by Stavniichuk, Anna, Hye Khan, Md. Abdul, Yeboah, Michael M., Chesnik, Marla A., Jankiewicz, Wojciech K., Hartmann, Markus, Blöcher, René, Kircher, Theresa, Savchuk, Olexiy, Proschak, Ewgenij, Imig, John D.

“…•Renal fibrosis is the most common pathophysiological event in chronic kidney disease (CKD) and is an independent predictor of long-term CKD prognosis.•A novel…”
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A dual COX-2/sEH inhibitor improves the metabolic profile and reduces kidney injury in Zucker diabetic fatty rat by Hye Khan, Md. Abdul, Hwang, Sung Hee, Sharma, Amit, Corbett, John A., Hammock, Bruce D., Imig, John D.

“…•We investigated effects of a novel dual acting molecule that concurrently inhibits two arachidonic acid metabolizing enzymes (cyclooxygenase-2 and soluble…”
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