Search Results - "Khan, Deena"

Identification of a common lupus disease-associated microRNA expression pattern in three different murine models of lupus by Dai, Rujuan, Zhang, Yan, Khan, Deena, Heid, Bettina, Caudell, David, Crasta, Oswald, Ahmed, S Ansar

“…Recent reports have shown that microRNAs (miRNAs) regulate vital immunological processes and have emerged as key regulators of immune system development and…”
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Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs by Khan, Deena, Ansar Ahmed, S

“…In recent years, IL-17A (IL-17), a pro-inflammatory cytokine, has received intense attention of researchers and clinicians alike with documented effects in…”
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Neutrophils and neutrophil serine proteases are increased in the spleens of estrogen-treated C57BL/6 mice and several strains of spontaneous lupus-prone mice by Dai, Rujuan, Cowan, Catharine, Heid, Bettina, Khan, Deena, Liang, Zhihong, Pham, Christine T N, Ahmed, S Ansar

“…Estrogen, a natural immunomodulator, regulates the development and function of diverse immune cell types. There is now renewed attention on neutrophils and…”
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Commercial rodent diets differentially regulate autoimmune glomerulonephritis, epigenetics and microbiota in MRL/lpr mice by Edwards, Michael R, Dai, Rujuan, Heid, Bettina, Cecere, Thomas E, Khan, Deena, Mu, Qinghui, Cowan, Catharine, Luo, Xin M, Ahmed, S Ansar

“…The course and severity of lupus in spontaneous murine lupus models varies among laboratories, which may be due to variations in diet, housing and/or local…”
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Deletion of microRNA-183-96-182 Cluster in Lymphocytes Suppresses Anti-DsDNA Autoantibody Production and IgG Deposition in the Kidneys in C57BL/6-Faslpr/lpr Mice by Wang, Zhuang, Heid, Bettina, Lu, Ran, Sachdeva, Mohit, Edwards, Michael R., Ren, JingJing, Cecere, Thomas E., Khan, Deena, Jeboda, Taschua, Kirsch, David G., Reilly, Christopher M., Dai, Rujuan, Ahmed, S. Ansar

“…Dysregulated miRNAs have been implicated in the pathogenesis of systemic lupus erythematosus (SLE). Our previous study reported a substantial increase in three…”
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The Immune System Is a Natural Target for Estrogen Action: Opposing Effects of Estrogen in Two Prototypical Autoimmune Diseases by Khan, Deena, Ansar Ahmed, S

“…Analogous to other physiological systems, the immune system also demonstrates remarkable sex differences. Although the reasons for sex differences in immune…”
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Estrogen increases, whereas IL-27 and IFN-γ decrease, splenocyte IL-17 production in WT mice by Khan, Deena, Dai, Rujuan, Karpuzoglu, Ebru, Ahmed, Sattar Ansar

“…Estrogen-mediated regulation of Th1, Th2 and Treg effector functions are well documented but, surprisingly, there is little information whether estrogen…”
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In vivo depletion of microRNA-183-96-182 cluster alleviates autoimmunity in B6- lpr lupus mice by Wang, Zhuang, Heid, Bettina, Lu, Ran, Khan, Deena, Ahmed, S Ansar, Dai, Rujuan

“…Abstract We have previously reported a significant upregulation of microRNA-183-96-182 cluster (miR-183C) in splenocytes of several murine lupus models. In…”
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Suppression of LPS-induced Interferon-γ and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: a novel mechanism of immune modulation by Dai, Rujuan, Phillips, Rebecca A., Zhang, Yan, Khan, Deena, Crasta, Oswald, Ahmed, S. Ansar

“…MicroRNAs (miRNAs), recently identified noncoding small RNAs, are emerging as key regulators in homeostasis of the immune system. Therefore, aberrant…”
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Depletion of microRNA-183-96-182 miRNA cluster in lymphocytes suppresses anti-dsDNA autoantibody production and IgG deposition in kidney in C57BL/6-Faslpr/lpr mice by Wang, Zhuang, Heid, Bettina, Ren, Jingjing, Edwards, Michael R, Cecere, Thomas E., Lu, Ran, Khan, Deena, Kirsch, David, Reilly, Christopher M., Dai, Rujuan, Ahmed, S. Ansar

“…Abstract The miR-183-96-182 (miR-183C) is a highly conserved miRNA cluster among species. Our previous work found a significant upregulation of miR-183C in the…”
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Sex differences and estrogen regulation of miRNAs in lupus, a prototypical autoimmune disease by Khan, Deena, Dai, Rujuan, Ansar Ahmed, S.

“…Unique dysregulated expression patterns of microRNAs (miRNAs) have been reported in many disease conditions including autoimmune diseases such as systemic…”
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Estrogen Regulates Transcription Factors STAT-1 and NF-κB to Promote Inducible Nitric Oxide Synthase and Inflammatory Responses by Dai, Rujuan, Phillips, Rebecca A., Karpuzoglu, Ebru, Khan, Deena, Ahmed, S. Ansar

“…Abstract Estrogen regulation of inflammatory responses has broad physiological and pathological consequences. However, the molecular mechanism of estrogen…”
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Epigenetic Regulation of Non-Lymphoid Cells by Bisphenol A, a Model Endocrine Disrupter: Potential Implications for Immunoregulation by Khan, Deena, Ahmed, S Ansar

“…Endocrine disrupting chemicals (EDC) abound in the environment since many compounds are released from chemical, agricultural, pharmaceutical, and consumer…”
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Deletion of microRNA-183-96-182 Cluster in Lymphocytes Suppresses Anti-DsDNA Autoantibody Production and IgG Deposition in the Kidneys in C57BL/6-Fas lpr/lpr Mice by Wang, Zhuang, Heid, Bettina, Lu, Ran, Sachdeva, Mohit, Edwards, Michael R, Ren, JingJing, Cecere, Thomas E, Khan, Deena, Jeboda, Taschua, Kirsch, David G, Reilly, Christopher M, Dai, Rujuan, Ahmed, S Ansar

“…Dysregulated miRNAs have been implicated in the pathogenesis of systemic lupus erythematosus (SLE). Our previous study reported a substantial increase in three…”
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Treatment with a selective histone deacetylase 6 inhibitor decreases lupus nephritis in NZB/W mice by Vieson, Miranda D, Gojmerac, Alexander M, Khan, Deena, Dai, Rujuan, van Duzer, John H, Mazitschek, Ralph, Caudell, David L, Liao, Xiaofeng, Luo, Xin M, Reilly, Christopher M

“…To date, there are 18 histone deacetylase (HDAC) enzymes, divided into four classes, which alter protein function by removing acetyl groups from lysine…”
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Estrogen regulates the expression and activity of serine proteases in mouse splenocytes (87.11) by Dai, Rujuan, Khan, Deena, Ahmed, S. Ansar

“…Abstract In addition to digesting proteins, serine proteases also play critical roles in regulation of inflammatory responses, innate and adaptive immunity via…”
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Altered miRNA expression in splenic lymphocytes in autoimmune-prone murine models with active lupus disease (167.9) by Dai, Rujuan, Heid, Bettina, Khan, Deena, Ahmed, S. Ansar

“…Abstract There is markedly increased recognition of physiological and pathological roles of miRNAs in immune system that impacts health and disease. While…”
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Estrogen increases, whereas IL-27 and IFN-γ decrease, splenocyte IL-17 production in wild type mice by Khan, Deena, Dai, Rujuan, Karpuzoglu, Ebru, Ahmed, S Ansar

“…Estrogen-mediated regulation of Th1, Th2 and Treg effector functions are well documented but, surprisingly, it is still not known whether estrogen modulates…”
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Estrogen increases, whereas IL-27 and IFN-[gamma] decrease, splenocyte IL-17 production in WT mice by Khan, Deena, Dai, Rujuan, Karpuzoglu, Ebru, Ahmed, Sattar Ansar

“…Estrogen-mediated regulation of Th1, Th2 and Treg effector functions are well documented but, surprisingly, there is little information whether estrogen…”
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Estrogen upregulates IL-17-secreting cells and IL-17 levels in normal and autoimmune mice: IL-27 and IFNγ downregulate IL-17 (143.50) by Khan, Deena, Dai, Rujuan, Karpuzoglu, Ebru, Ahmed, S. Ansar

“…Abstract Estrogen, an important immunomodulator, plays critical role in gender related immune disorders including autoimmune diseases by regulating Th1, Th2…”
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