Search Results - "Khan, C. M. Anjam"

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2 by Hatton, Catherine F., Botting, Rachel A., Dueñas, Maria Emilia, Haq, Iram J., Verdon, Bernard, Thompson, Benjamin J., Spegarova, Jarmila Stremenova, Gothe, Florian, Stephenson, Emily, Gardner, Aaron I., Murphy, Sandra, Scott, Jonathan, Garnett, James P., Carrie, Sean, Powell, Jason, Khan, C. M. Anjam, Huang, Lei, Hussain, Rafiqul, Coxhead, Jonathan, Davey, Tracey, Simpson, A. John, Haniffa, Muzlifah, Hambleton, Sophie, Brodlie, Malcolm, Ward, Chris, Trost, Matthias, Reynolds, Gary, Duncan, Christopher J. A.

“…The nasal epithelium is a plausible entry point for SARS-CoV-2, a site of pathogenesis and transmission, and may initiate the host response to SARS-CoV-2…”
Get full text

Role of the universal stress protein UspA of Salmonella in growth arrest, stress and virulence by Liu, Wen-Tssann, Karavolos, Michail H., Bulmer, David M., Allaoui, Abdelmounaaïm, Hormaeche, Raquel Demarco Carlos E., Lee, Jeong Jin, Anjam Khan, C.M.

“…Pathogenic bacteria employ a variety of mechanisms to resist a barrage of stresses they encounter during active growth in or outside the host as well as during…”
Get full text

The bacterial cytoskeleton modulates motility, type 3 secretion, and colonization in Salmonella by Bulmer, David M, Kharraz, Lubna, Grant, Andrew J, Dean, Paul, Morgan, Fiona J E, Karavolos, Michail H, Doble, Anne C, McGhie, Emma J, Koronakis, Vassilis, Daniel, Richard A, Mastroeni, Pietro, Khan, C M Anjam

“…Although there have been great advances in our understanding of the bacterial cytoskeleton, major gaps remain in our knowledge of its importance to virulence…”
Get full text

Adrenaline modulates the global transcriptional profile of Salmonella revealing a role in the antimicrobial peptide and oxidative stress resistance responses by Karavolos, M H, Spencer, H, Bulmer, D M, Thompson, A, Winzer, K, Williams, P, Hinton, J C D, Khan, C M Anjam

“…The successful interaction of bacterial pathogens with host tissues requires the sensing of specific chemical and physical cues. The human gut contains a huge…”
Get full text

structure and proinflammatory activity of the lipopolysaccharide from Burkholderia multivorans and the differences between clonal strains colonizing pre and posttransplanted lungs by Ieranò, Teresa, Silipo, Alba, Sturiale, Luisa, Garozzo, Domenico, Brookes, Heather, Khan, C.M. Anjam, Bryant, Clare, Gould, F. Kate, Corris, Paul A, Lanzetta, Rosa, Parrilli, Michelangelo, De Soyza, Anthony, Molinaro, Antonio

“…The Burkholderia cepacia complex is a group of Gram-negative bacteria that are opportunistic pathogens for humans especially in cystic fibrosis patients…”
Get full text

Interkingdom crosstalk: Host neuroendocrine stress hormones drive the hemolytic behavior of Salmonella typhi by Karavolos, Michail H., Williams, Paul, Khan, C.M. Anjam

“…The ability of bacterial pathogens to sense their immediate environment plays a significant role on their capacity to survive and cause disease. Salmonella…”
Get full text

Multidirectional chemical signalling between Mammalian hosts, resident microbiota, and invasive pathogens: neuroendocrine hormone-induced changes in bacterial gene expression by Karavolos, Michail H, Khan, C M Anjam

“…Host-pathogen communication appears to be crucial in establishing the outcome of bacterial infections. There is increasing evidence to suggest that this…”
Get more information

Targeting the Bacterial Cytoskeleton of the Burkholderia cepacia Complex for Antimicrobial Development: A Cautionary Tale by Carnell, Sonya C, Perry, John D, Borthwick, Lee, Vollmer, Daniela, Biboy, Jacob, Facchini, Marcella, Bragonzi, Alessandra, Silipo, Alba, Vergunst, Annette C, Vollmer, Waldemar, Khan, Anjam C M, De Soyza, Anthony

“…complex (BCC) bacteria are a group of opportunistic pathogens that cause severe lung infections in cystic fibrosis (CF). Treatment of BCC infections is…”
Get full text

The Complete Structure and Pro-inflammatory Activity of the Lipooligosaccharide of the Highly Epidemic and Virulent Gram-Negative Bacterium Burkholderia cenocepacia ET-12 (Strain J2315) by Silipo, Alba, Molinaro, Antonio, Ieranò, Teresa, De Soyza, Anthony, Sturiale, Luisa, Garozzo, Domenico, Aldridge, Christine, Corris, Paul A., Khan, C. M. Anjam, Lanzetta, Rosa, Parrilli, Michelangelo

“…Members of genus Burkholderia include opportunistic Gram‐negative bacteria that are responsible for serious infections in immunocompromised and cystic fibrosis…”
Get full text

In vitro activity of S -(3,4-dichlorobenzyl)isothiourea hydrochloride and novel structurally related compounds against multidrug-resistant bacteria, including Pseudomonas aeruginosa and Burkholderia cepacia complex by Nicholson, Audrey, Perry, John D, James, Arthur L, Stanforth, Stephen P, Carnell, Sonya, Wilkinson, Kathryn, Anjam Khan, C.M, De Soyza, Anthony, Gould, F. Kate

“…Abstract The aim of this study was to establish the antimicrobial activities of S -(3,4-dichlorobenzyl)isothiourea hydrochloride (A22) and a series of…”
Get full text

Genetic control of immune response to recombinant antigens carried by an attenuated Salmonella typhimurium vaccine strain : Nramp1 influences T-helper subset responses and protection against Leishmanial challenge by SOO, S.-S, VILLARREAL-RAMOS, B, ANJAM KHAN, C. M, HORMAECHE, C. E, BLACKWELL, J. M

“…Attenuated strains of Salmonella typhimurium have been widely used as vehicles for delivery and expression of vaccine antigens in murine models of infectious…”
Get full text

LuxS-Based Quorum Sensing Does Not Affect the Ability of Salmonella enterica Serovar Typhimurium To Express the SPI-1 Type 3 Secretion System, Induce Membrane Ruffles, or Invade Epithelial Cells by Perrett, Charlotte A, Karavolos, Michail H, Humphrey, Suzanne, Mastroeni, Pietro, Martinez-Argudo, Isabel, Spencer, Hannah, Bulmer, David, Winzer, Klaus, McGhie, Emma, Koronakis, Vassilis, Williams, Paul, Khan, C M Anjam, Jepson, Mark A

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Burkholderia cenocepacia Lipopolysaccharide, Lipid A, and Proinflammatory Activity by De Soyza, Anthony, Ellis, Charles D, Khan, C. M. Anjam, Corris, Paul A, de Hormaeche, Raquel Demarco

“…Organisms from the Burkholderia cepacia complex are important pathogens in cystic fibrosis and are associated with increased rates of sepsis and death. These…”
Get full text

Pathogen espionage: multiple bacterial adrenergic sensors eavesdrop on host communication systems by Karavolos, Michail H., Winzer, Klaus, Williams, Paul, Khan, C. M. Anjam

“…Summary The interactions between bacterial pathogens and their eukaryotic hosts are vital in determining the outcome of infections. Bacterial pathogens employ…”
Get full text

Genetic detoxification of an aroA Salmonella enterica serovar Typhimurium vaccine strain does not compromise protection against virulent Salmonella and enhances the immune responses towards a protective malarial antigen by McKelvie, Nicola D, Khan, Shahid A, Karavolos, Michail H, Bulmer, David M, Lee, Jeong Jin, DeMarco, Raquel, Maskell, Duncan J, Zavala, Fidel, Hormaeche, Carlos E, Anjam Khan, C.M

“…Live Salmonella vaccines are limited in use by the inherent toxicity of the lipopolysaccharide. The waaN gene encodes a myristyl transferase required for the…”
Get full text

Who's talking to whom? Epithelial-bacterial pathogen interactions by ALDRIDGE, Phillip D, GRAY, Michael A, HIRST, Barry H, ANJAM KHAN, C. M

“…Our perception that host-bacterial interactions lead to disease comes from rare, unsuccessful interactions resulting in the development of detectable symptoms…”
Get full text

Conjunctival epithelial cells resist productive SARS-CoV-2 infection by Jackson, Robert M, Hatton, Catherine F, Spegarova, Jarmila Stremenova, Georgiou, Maria, Collin, Joseph, Stephenson, Emily, Verdon, Bernard, Haq, Iram J, Hussain, Rafiqul, Coxhead, Jonathan M, Mudhar, Hardeep-Singh, Wagner, Bart, Hasoon, Megan, Davey, Tracey, Rooney, Paul, Khan, C M Anjam, Ward, Chris, Brodlie, Malcolm, Haniffa, Muzlifah, Hambleton, Sophie, Armstrong, Lyle, Figueiredo, Francisco, Queen, Rachel, Duncan, Christopher J A, Lako, Majlinda

“…Conjunctival epithelial cells, which express viral-entry receptors angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine type 2 (TMPRSS2),…”
Get full text

Expression of disulphide-bridge-dependent conformational epitopes and immunogenicity of the carboxy-terminal 19 kDa domain of Plasmodium yoelii merozoite surface protein-1 in live attenuated Salmonella vaccine strains by Somner, Elizabeth A, Ogun, Solabomi A, Sinha, Katharine A, Spencer Valero, Lilian M, Lee, Jeong Jin, Harrison, Julia A, Holder, Anthony A, Hormaeche, Carlos E, Khan, Anjam C. M

“…Department of Microbiology, The Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK Division of Parasitology, National Institute for…”
Get full text

Salmonella Typhi sense host neuroendocrine stress hormones and release the toxin haemolysin E by Karavolos, Michail H, Bulmer, David M, Spencer, Hannah, Rampioni, Giordano, Schmalen, Ira, Baker, Stephen, Pickard, Derek, Gray, Joe, Fookes, Maria, Winzer, Klaus, Ivens, Alasdair, Dougan, Gordon, Williams, Paul, Khan, C M Anjam

“…Salmonella enterica serovar Typhi ( S. typhi ) causes typhoid fever. We show that exposure of S. typhi to neuroendocrine stress hormones results in haemolysis,…”
Get full text

The Neisseria gonorrhoeae lpxLII gene encodes for a late‐functioning lauroyl acyl transferase, and a null mutation within the gene has a significant effect on the induction of acute inflammatory responses by Ellis, Charles D., Lindner, Buko, Khan, C. M. Anjam, Zähringer, Ulrich, De Hormaeche, Raquel Demarco

“…LPS is a fundamental constituent of the outer membrane of all Gram‐negative bacteria, and the lipid A domain plays a central role in the induction of…”
Get full text